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Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.

Abstract：

BACKGROUND/OBJECTIVES:Delirium is common in older adults, especially following hospitalization. Because low vitamin D levels may be associated with increased delirium risk, we aimed to determine the prognostic value of blood vitamin D levels, extending our previous genetic analyses of this relationship. DESIGN:Prospective cohort analysis. SETTING:Community-based cohort study of adults from 22 cities across the United Kingdom (the UK Biobank). PARTICIPANTS:Adults aged 60 and older by the end of follow-up in the linked hospital inpatient admissions data, up to 14 years after baseline (n = 351,320). MEASUREMENTS:At baseline, serum vitamin D (25-OH-D) levels were measured. We used time-to-event models to estimate hazard ratios (HRs) and 95% confidence intervals (CIs) for the association between vitamin D deficiency and incident hospital-diagnosed delirium, adjusted for age, sex, assessment month, assessment center, and ethnicity. We performed Mendelian randomization genetic analysis in European participants to further investigate vitamin D and delirium risk. RESULTS:A total of 3,634 (1.03%) participants had at least one incident hospital-diagnosed delirium episode. Vitamin D deficiency (<25 nmol/L) predicted a large incidence in delirium (HR = 2.49; 95% CI = 2.24-2.76; P = 3*10-68 , compared with >50 nmol/L). Increased risk was not limited to the deficient group: insufficient levels (25-50 nmol/L) were also at increased risk (HR = 1.38; 95% CI = 1.28-1.49; P = 4*10-18 ). The association was independent of calcium levels, hospital-diagnosed fractures, dementia, and other relevant cofactors. In genetic analysis, participants carrying more vitamin D-increasing variants had a reduced likelihood of incident delirium diagnosis (HR = .80 per standard deviation increase in genetically instrumented vitamin D: .73-.87; P = 2*10-7 ). CONCLUSION:Progressively lower vitamin D levels predicted increased risks of incident hospital-diagnosed delirium, and genetic evidence supports a shared causal pathway. Because low vitamin D levels are simple to detect and inexpensive and safe to correct, an intervention trial to confirm these results is urgently needed.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Pilling LC,Jones LC,Masoli JAH,Delgado J,Atkins JL,Bowden J,Fortinsky RH,Kuchel GA,Melzer D

doi

10.1111/jgs.16853

subject

Has Abstract

pub_date

2020-10-05 00:00:00

eissn

0002-8614

issn

1532-5415

pub_type

杂志文章

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Low Vitamin D Levels and Risk of Incident Delirium in 351,000 Older UK Biobank Participants.