Abstract：
OBJECTIVES:To investigate statin use and pain in people with cancer aged 70 to 79 and 80 and older. DESIGN:Cross-sectional. SETTING:Medical oncology outpatient clinic at the Royal Adelaide Hospital. PARTICIPANTS:Individuals aged 70 and older who presented consecutively between January 2009 and June 2010 (n = 385), of whom 106 were aged 80 and older. MEASUREMENTS:Participants completed a structured data collection instrument, documenting medication use, comorbidities and a general pain assessment (10-point visual analogue scale (VAS)). Unadjusted and adjusted logistic regression was used to compute odds ratios (ORs) and 95% confidence intervals (CIs) for factors associated with statin use. RESULTS:The prevalence of statin use was 35% (n = 97) in people aged 70 to 79 and 39% (n = 41) in those aged 80 and older. After adjusting for age, sex, Charlson Comorbidity Index, and analgesic use, statin use was associated with self-reported pain (VAS ≥ 5) (OR = 4.09, 95% CI = 1.32-12.68) in people aged 80 and older but not in those aged 70 to 79. Half of participants using statins (51% n = 70) had a palliative treatment approach. Of the 41 statin users aged 80 and older, 20 (49%) were using statins for primary prevention. CONCLUSION:The prevalence of statin use was similar in people aged 70 to 79 years and those aged 80 and older, with statin use associated with self-reported pain in people aged 80 and older. This highlights a potential benefit of "deprescribing" statins in older people with cancer, especially those aged 80 and older.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Turner JP,Shakib S,Singhal N,Hogan-Doran J,Prowse R,Johns S,Thynne T,Bell JSdoi
10.1111/jgs.13051subject
Has Abstractpub_date
2014-10-01 00:00:00pages
1900-5issue
10eissn
0002-8614issn
1532-5415journal_volume
62pub_type
杂志文章abstract：OBJECTIVES:To examine in cognitively normal elderly adults whether vascular factors predict cognitive decline and whether these associations are mediated by magnetic resonance imaging (MRI) measures of subclinical vascular brain injury. DESIGN:Prospective multisite longitudinal study of subcortical ischemic vascular d...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1532-5415.2011.03839.x
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:To evaluate the effectiveness of exercise and amino acid supplementation in enhancing muscle mass and strength in community-dwelling elderly sarcopenic women. DESIGN:Randomized controlled trial. SETTING:Urban community in Tokyo, Japan. PARTICIPANTS:One hundred fifty-five women aged 75 and older were defin...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1532-5415.2011.03776.x
更新日期：2012-01-01 00:00:00
abstract：:Despite recent gains in establishing academic sections, divisions, and departments of geriatrics in medical schools, much remains to be done to meet the medical needs of an aging population. To better understand how medical schools are educating students in geriatric-related topics, all U.S. allopathic and osteopathic...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2005.53023.x
更新日期：2005-01-01 00:00:00
abstract：OBJECTIVES:To evaluate the relationship between frailty and delirium. DESIGN:Systematic review and meta-analysis. SETTING:MEDLINE, EMBASE, PubMed, Scopus, Web of Science, and Google Scholar databases were searched for articles on frailty and delirium published on or before October 31, 2017. PARTICIPANTS:Individuals ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,meta分析
doi：10.1111/jgs.15503
更新日期：2018-10-01 00:00:00
abstract：OBJECTIVES:To investigate whether higher circulating levels of C-reactive protein (CRP), interleukin-6 (IL-6), and alpha1-antichymotrypsin (ACT) are associated with worse cognitive function and decline in old age. DESIGN:Two independent population-based cohort studies. SETTING:The Rotterdam Study (mean follow-up 4.6 ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2007.01159.x
更新日期：2007-05-01 00:00:00
abstract：:During 26 years of surveillance of the Framingham Study Cohort of 5,209 subjects, 176 men and 119 women developed occlusive peripheral arterial disease manifested as intermittent claudication (IC). The incidence increased sharply with age until the age of 75, with about a twofold male predominance at all ages. An inci...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1985.tb02853.x
更新日期：1985-01-01 00:00:00
abstract：OBJECTIVES:To demonstrate reliability and feasibility of a standardized protocol to assess and score quality indicators relevant to pressure ulcer (PU) care processes in nursing homes (NHs). DESIGN:Descriptive. SETTING:Eight NHs. PARTICIPANTS:One hundred ninety-one NH residents for whom the PU Resident Assessment Pr...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2003.51402.x
更新日期：2003-09-01 00:00:00
abstract：OBJECTIVE:To describe a broad range of physical disability by examining the association between a four-level measure of disability, based on self-report of difficulty in performing functional activities, and previously identified risk factors for disability. DESIGN:Cross-sectional. SETTING:Community-based. PARTICIPA...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1996.tb04065.x
更新日期：1996-12-01 00:00:00
abstract：OBJECTIVES:To describe and provide baseline data from The National Pressure Ulcer Long-Term Care Study (NPULS). DESIGN:Retrospective cohort study of detailed resident characteristics, treatments, and outcomes using convenience sampling. SETTING:One hundred nine long-term care facilities throughout the United States. ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2002.50510.x
更新日期：2002-11-01 00:00:00
abstract：BACKROUND:Baseline depressive symptoms have been consistently associated with the onset of cardiovascular disease (CVD). OBJECTIVES:Since depressive symptoms vary over time in elderly persons, and to help clarify whether or not depression is an etiological factor for CVD, we quantified the association between the cour...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/jgs.13872
更新日期：2016-01-01 00:00:00
abstract：OBJECTIVES:To determine the prognostic value of apathy for mortality in patients of somatic (SC) and dementia special care (DSC) nursing home (NH) units. DESIGN:Longitudinal design, secondary analyses of a 2-year, cluster-randomized trial with six measurements, approximately 4 months in between. SETTING:SC and DSC-un...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/jgs.15007
更新日期：2017-10-01 00:00:00
abstract：UNLABELLED:This longitudinal study of glucose tolerance in the residents of a Jewish home for the aged (JHA) is now in its 25th year. Of 1,177 supposedly nondiabetic persons screened on admission from 1965 to 1986, 22.5% had impaired glucose tolerance (IGT), reflecting its undiagnosed prevalence among the Jewish elderl...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1989.tb06676.x
更新日期：1989-12-01 00:00:00
abstract：OBJECTIVES:To ascertain the association between self-report of low mood and unobtrusively measured behaviors (walking speed, time out of residence, frequency of room transitions, and computer use) in community-dwelling older adults using novel monitoring technologies. DESIGN:Longitudinal cohort study of older adults w...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.12744
更新日期：2014-04-01 00:00:00
abstract：BACKGROUND/OBJECTIVES:Delirium is common in older adults, especially following hospitalization. Because low vitamin D levels may be associated with increased delirium risk, we aimed to determine the prognostic value of blood vitamin D levels, extending our previous genetic analyses of this relationship. DESIGN:Prospec...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.16853
更新日期：2020-10-05 00:00:00
abstract：OBJECTIVES:To determine whether obese older adults who qualify for nursing home (NH) placement are as likely as nonobese adults to be admitted to NHs that provide adequate quality of care. DESIGN:Retrospective study. SETTING:NHs in New York State. PARTICIPANTS:Individuals aged 65 and older newly admitted to a NH in ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.14105
更新日期：2016-05-01 00:00:00
abstract：OBJECTIVE:To determine the prevalence of diabetes and examine its association with food intake, anthropometric and metabolic variables, and other coronary risk factors in urban and rural older Mexican populations. DESIGN:A cross-sectional study. SETTING:Three Mexican communities (urban areas of medium and low income ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1998.tb06005.x
更新日期：1998-11-01 00:00:00
abstract：OBJECTIVES:To compare relationships between the sleep-wake cycle and endogenous circadian rhythms in young and older adults and to examine correlates between evening naps and circadian rhythms in older adults. DESIGN:For 1 week of home recording, subjects wore wrist-activity monitors and kept daily sleep logs. After t...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1046/j.1532-5415.2003.51356.x
更新日期：2003-08-01 00:00:00
abstract：:The Mini-Mental State Examination and the WAIS-R were administered to 105 patients in the early stages of Alzheimer's disease. MMSE scores correlated 0.83 with full scale IQ, which indicates that the MMSE may be a reasonable alternative measure of overall intellectual functioning in Alzheimer patients, for whom more e...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1988.tb04020.x
更新日期：1988-06-01 00:00:00
abstract：BACKGROUND:The impact of parkinsonism on survival in older persons independent of dementia is not well understood. METHODS:Participants in the clinical examination of the Canadian Study of Health and Aging who had parkinsonism and were older than age 65 were identified. The impact of parkinsonism on 5-year survival wa...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2000.tb04701.x
更新日期：2000-04-01 00:00:00
abstract：PURPOSE:To determine whether the management of heart failure by specialized multidisciplinary heart failure disease-management programs was associated with improved outcomes. BACKGROUND:The advent of angiotensin-converting enzyme inhibitors, beta-blockers, and spironolactone has revolutionized the management of heart ...
journal_title：Journal of the American Geriatrics Society
pub_type： 评论,杂志文章
doi：10.1046/j.1532-5415.2002.50418.x
更新日期：2002-09-01 00:00:00
abstract：OBJECTIVES:To assess whether the relationship between antidepressant adherence and coronary artery disease (CAD) hospitalizations varied between older and younger adults with depression. DESIGN:Retrospective cohort study. SETTING:Department of Veterans Affairs outpatient clinics nationwide. PARTICIPANTS:Chronically ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.12849
更新日期：2014-07-01 00:00:00
abstract：OBJECTIVES:To determine whether adhering to a healthy lifestyle in midlife may reduce the risk of dementia. DESIGN:Case-control study nested in a prospective cohort. SETTING:The Honolulu-Asia Aging Study, Oahu, Hawaii. PARTICIPANTS:Three thousand four hundred sixty-eight Japanese-American men (mean age 52 in 1965-19...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2011.03768.x
更新日期：2012-01-01 00:00:00
abstract：OBJECTIVE:To examine the association of self-reported physical activity with performance-based and self-reported physical functioning measured 3 to 5 years later. DESIGN:A population-based, longitudinal study. SETTING:The island of Oahu, Hawaii. PARTICIPANTS:Subjects were 3640 Japanese-American men older than 70 yea...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1995.tb05525.x
更新日期：1995-08-01 00:00:00
abstract：:In this paper, we present the consensus statement from a national conference on research priorities and methodologies for studying geriatric evaluation and management (GEM) programs. These conclusions, discussion points, and recommendations resulted from discussions of plenary papers, working group deliberations, and ...
journal_title：Journal of the American Geriatrics Society
pub_type： 共识发展会议,杂志文章,评审
doi：10.1111/j.1532-5415.1991.tb05936.x
更新日期：1991-09-01 00:00:00
abstract：BACKGROUND:Although frailty status is dynamic, whether improvements in frailty predict mortality is unknown. OBJECTIVE:Describe 1-year changes in a frailty index (FI) and association with 48-month mortality. DESIGN:Secondary analysis of the National Health in Aging Trends Study. SETTING:Community. PARTICIPANTS:Five...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/jgs.17002
更新日期：2020-12-29 00:00:00
abstract：OBJECTIVES:To examine the relationship between persistently high depressive symptoms and long-term changes in functional disability in elderly persons. DESIGN:A community-based, prospective, observational study. SETTING:Participant data from the Cardiovascular Health Study. PARTICIPANTS:From the overall sample of 5,...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2005.53202.x
更新日期：2005-04-01 00:00:00
abstract：OBJECTIVE:Recent studies have suggested that vascular dementia in older persons is more common than previously hypothesized. A substantial proportion of dementia in old age may be an early manifestation of cerebrovascular disease (CVD), that eventually becomes clinically evident as an acute cerebrovascular accident. Th...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.1996.tb00908.x
更新日期：1996-03-01 00:00:00
abstract：OBJECTIVES:To assess how various stakeholders involved with nursing home care rate the importance of various quality-of-life (QoL) items for hypothetical residents with varying types of impairment. DESIGN:A community-based exploratory description of a convenience sample. SETTING:Eleven nursing homes in Florida, New J...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,多中心研究
doi：10.1111/j.1532-5415.2005.00493.x
更新日期：2005-12-01 00:00:00
abstract：OBJECTIVES:To identify factors that influence the breast cancer treatment decisions of women aged 80 and older. DESIGN:Medical record review. SETTING:One academic primary care clinic and two community health centers in Boston. PARTICIPANTS:Sixty-five women aged 80 and older diagnosed with breast cancer between 1994 ...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2011.03820.x
更新日期：2012-03-01 00:00:00
abstract：OBJECTIVES:To assess the prevalence and correlates of potentially harmful drug-drug combinations and drug-disease combinations prescribed for elderly patients at outpatient settings. DESIGN:Retrospective analysis of the 1995-2000 National Ambulatory Medical Care Survey (NAMCS) and the National Hospital Ambulatory Medi...
journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2005.53112.x
更新日期：2005-02-01 00:00:00
