Abstract：
BACKGROUND:The impact of parkinsonism on survival in older persons independent of dementia is not well understood. METHODS:Participants in the clinical examination of the Canadian Study of Health and Aging who had parkinsonism and were older than age 65 were identified. The impact of parkinsonism on 5-year survival was determined for a combined cohort with and without dementia, and a stratified analysis was then conducted for the subgroups with Alzheimer's disease (AD) and those without dementia. Subjects with a previous diagnosis of Parkinson's disease and those prescribed drugs causing extrapyramidal side effects were excluded. FINDINGS:A total of 721 subjects with AD and 1705 subjects without dementia were examined. After adjusting for age and residential status (community vs institution), parkinsonism was associated with poorer survival in the combined cohort (risk ratio 1.51; 95% CI, 1.22-1.85), in those with AD (risk ratio 1.34; 95% CI, 1.02-1.76), and those without dementia (risk ratio 1.54; 95% CI, 1.11-2.15). In the combined cohort, parkinsonism remained independently associated with higher mortality after adjusting for AD status (risk ratio 1.39; 95% CI, 1.13-1.72). In the subgroup with AD, parkinsonism remained associated with poorer survival after adjusting for severity of cognitive impairment (risk ratio 1.33; 95% CI. 1.04-1.74). INTERPRETATION:Parkinsonism is significantly associated with poorer survival in older persons, regardless of whether they have dementia.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Mitchell SL,Rockwood Kdoi
10.1111/j.1532-5415.2000.tb04701.xsubject
Has Abstractpub_date
2000-04-01 00:00:00pages
422-5issue
4eissn
0002-8614issn
1532-5415journal_volume
48pub_type
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journal_title：Journal of the American Geriatrics Society
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doi：10.1111/j.1532-5415.1996.tb01371.x
更新日期：1996-10-01 00:00:00
abstract：:Leaders of geriatric programs at academic health centers (AHCs) face several challenges in seeking support for clinical program development. These challenges relate to how revenues from Medicare activities flow within AHCs. Typically, clinical departments such as the Department of Medicine see a very small proportion ...
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更新日期：2006-01-01 00:00:00
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pub_type： 临床试验,杂志文章
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更新日期：2002-04-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
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doi：10.1111/j.1532-5415.1991.tb02702.x
更新日期：1991-08-01 00:00:00
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doi：10.1111/jgs.15296
更新日期：2018-03-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
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更新日期：2005-05-01 00:00:00
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doi：10.1111/jgs.15899
更新日期：2019-08-01 00:00:00
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pub_type： 杂志文章,多中心研究,随机对照试验
doi：10.1111/j.1532-5415.2008.01643.x
更新日期：2008-05-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章
doi：10.1111/j.1532-5415.2007.01196.x
更新日期：2007-06-01 00:00:00
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pub_type： 杂志文章
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更新日期：1979-06-01 00:00:00
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更新日期：2020-11-12 00:00:00
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journal_title：Journal of the American Geriatrics Society
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更新日期：1981-10-01 00:00:00
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journal_title：Journal of the American Geriatrics Society
pub_type： 杂志文章,评审
doi：
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