Abstract:
OBJECTIVES:To characterize a comprehensive outline of the oral microflora related to pneumonia in older adults. DESIGN:Prospective and retrospective longitudinal study. SETTING:Community. PARTICIPANTS:Long-term hospitalized patients and people in nursing homes (343 subjects, aged > or =65). MEASUREMENTS:Subjects were assessed at baseline for pneumonia-related health problems. The flora of the tongue coating was characterized according to terminal restriction fragment length polymorphism (T-RFLP) analysis. All subjects were followed prospectively for 6 months for a diagnosis of pneumonia. The number of febrile days (>37.5 degrees C) was assessed in 299 subjects who were observed for 12 months (retrospectively for 6 months and prospectively for 6 months). The follow-up data were analyzed using multivariate regression analyses in relation to the baseline data, including T-RFLP patterns. RESULTS:T-RFLP patterns outlining the floral composition of the tongue coating were grouped into Clusters A, B, C, and D. According to Cox regression analysis, the subjects in Clusters C (hazard ratio (HR)=4.0, 95% confidence interval (CI)=1.1-15.1) and D (HR=4.9, 95% CI=1.2-21.1) were at a significantly greater risk of pneumonia than those in Cluster A, independent of other confounding factors. Logistic regression analysis adjusting for the same covariates indicated that the number of subjects with more than 9 febrile days per year was significantly lower in Cluster A than in the other clusters. CONCLUSION:The comprehensive microfloral profile of the tongue coating is closely related to pneumonia-related health problems in institutionalized older adults.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Takeshita T,Tomioka M,Shimazaki Y,Matsuyama M,Koyano K,Matsuda K,Yamashita Ydoi
10.1111/j.1532-5415.2010.02867.xsubject
Has Abstractpub_date
2010-06-01 00:00:00pages
1050-7issue
6eissn
0002-8614issn
1532-5415pii
JGS2867journal_volume
58pub_type
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