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Serum insulin-like growth factor-1 binding proteins 1 and 2 and mortality in older adults: the Health, Aging, and Body Composition Study.

Abstract：

OBJECTIVE:To evaluate the relationship between serum insulin-like growth factor 1 (IGF-1), IGF-1 binding protein 1 (IGFBP-1), and IGF-1 binding protein 2 (IGFBP-2) and fasting insulin, fasting glucose, adiposity, and mortality in older adults. DESIGN:A prospective cohort study with mean follow-up of 6.2 years. SETTING:Participants were recruited and followed at two centers affiliated with academic medical institutions. PARTICIPANTS:Six hundred twenty-five men and women aged 70 and older and in good health at the time of enrollment. MEASUREMENTS:Serum IGF-1, IGFBP-1, and IGFBP-2; fasting serum insulin; fasting serum glucose; visceral fat; and total percent fat. RESULTS:Higher IGFBP-1 and higher IGFBP-2 were significantly associated with lower fasting insulin, lower fasting glucose, and lower adiposity, but higher IGFBP-1 and IGFBP-2 were associated with greater mortality. In multivariate adjusted models, the hazard ratio for all-cause mortality was 1.48 (95% confidence interval (CI)=1.14-1.92) per standard deviation (SD) increase in IGFBP-2 and 1.34 (95% CI=1.01-1.76) per SD increase in IGFBP-1. No association was found between IGF-1 and all-cause mortality. CONCLUSIONS:Higher IGFBP-1 and IGFBP-2 are associated with lower adiposity and decreased glucose tolerance but also with greater all-cause mortality. Higher levels of serum IGF-1 binding protein (IGFBP) may indicate greater IGF-1 activity and thus represent an association between higher IGF-1 activity and mortality in humans.

journal_name

J Am Geriatr Soc

journal_title

Journal of the American Geriatrics Society

authors

Hu D,Pawlikowska L,Kanaya A,Hsueh WC,Colbert L,Newman AB,Satterfield S,Rosen C,Cummings SR,Harris TB,Ziv E,Health, Aging, and Body Composition Study.

doi

10.1111/j.1532-5415.2009.02318.x

subject

Has Abstract

pub_date

2009-07-01 00:00:00

pages

1213-8

issue

7

eissn

0002-8614

issn

1532-5415

pii

JGS2318

journal_volume

57

pub_type

杂志文章

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