Associations between serum 25-hydroxyvitamin D concentrations and multiple health conditions, physical performance measures, disability, and all-cause mortality: the Concord Health and Ageing in Men Project.

Abstract:

OBJECTIVES:To explore associations between serum 25-hydroxyvitamin D (25(OH)D) levels and a wide range of health conditions, physical performance measures, disability, and mortality in a large epidemiological study to identify an optimum range for 25(OH)D concentrations. DESIGN:Cross-sectional study, with additional prospective data on falls and mortality. SETTING:Concord Health and Ageing in Men Project, Sydney, Australia. PARTICIPANTS:Community-dwelling men aged 70 and older (N = 1,659). MEASUREMENTS:Serum 25(OH)D levels, general health status, self-reported diseases, physical performance measures, disability (activities of daily living and instrumental activities of daily living) and falls. RESULTS:Fair, poor, and very poor health; self-reported diabetes mellitus; hyperglycemia; depression; muscle weakness; poor balance; and all-cause mortality were all associated with serum 25(OH)D levels less than 50 nmol/L, even after adjustment for confounding. The findings also suggest that, in older men, for a wide range of health conditions, physical performance measures, disability, falls, and mortality, the optimum range of 25(OH)D is between 50.0 and 74.9 nmol/L, with no additional benefit for 25(OH)D levels of 75.0 nmol/L or greater. CONCLUSION:Programs aimed at achieving an optimum range of serum 25(OH)D at levels between 50.0 and 74.9 nmol/L may have overall health benefits and such levels are adequate for older men.

journal_name

J Am Geriatr Soc

authors

Hirani V,Cumming RG,Naganathan V,Blyth F,Le Couteur DG,Handelsman DJ,Waite LM,Seibel MJ

doi

10.1111/jgs.12693

subject

Has Abstract

pub_date

2014-03-01 00:00:00

pages

417-25

issue

3

eissn

0002-8614

issn

1532-5415

journal_volume

62

pub_type

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