Severe impairment of dietary folate utilization in the elderly.

Abstract:

:Absorption of folates, vitamin B6, pantothenate, and riboflavin from a natural food source (yeast) and from synthetic folylmonoglutamate was studied in 24 elderly subjects (age range, 73 to 101 years) and in 12 healthy younger subjects (age range, 24 to 42 years). All subjects absorbed riboflavin, vitamin B6, and pantothenate from yeast. Ingested folypolyglutamates (the preponderant folates in yeast) proved to be a very poor source of folates for the elderly subjects, whereas synthetic folylmonoglutamate served as a good source. In the younger subjects, yeast was a significant folate source. It is suggested that the folate deficits so common in the elderly are caused by impaired ability to obtain folate from ingested foods. The resultant folate deficit may induce changes in the epithelial structure and enzyme secretion of the small bowel, which may further exacerbate folate malabsorption.

journal_name

J Am Geriatr Soc

authors

Baker H,Jaslow SP,Frank O

doi

10.1111/j.1532-5415.1978.tb01962.x

subject

Has Abstract

pub_date

1978-05-01 00:00:00

pages

218-21

issue

5

eissn

0002-8614

issn

1532-5415

journal_volume

26

pub_type

杂志文章
  • Deprescribing in Older People Approaching End of Life: A Randomized Controlled Trial Using STOPPFrail Criteria.

    abstract:OBJECTIVES:Older people approaching end of life are commonly prescribed multiple medications, many of which may be inappropriate or futile. Our objective was to examine the effect of applying the STOPPFrail, a recently developed deprescribing tool, to the medication regimens of older patients with advanced frailty. DE...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16278

    authors: Curtin D,Jennings E,Daunt R,Curtin S,Randles M,Gallagher P,O'Mahony D

    更新日期:2020-04-01 00:00:00

  • Neighborhood deprivation, individual socioeconomic status, and frailty in older adults.

    abstract:OBJECTIVES:To assess how individual socioeconomic status and neighborhood deprivation affect frailty. DESIGN:Nationally representative population-based study, the English Longitudinal Study of Aging (ELSA), analyzed cross-sectionally. PARTICIPANTS:Four thousand eight hundred eighteen individuals aged 65 and older. M...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02480.x

    authors: Lang IA,Hubbard RE,Andrew MK,Llewellyn DJ,Melzer D,Rockwood K

    更新日期:2009-10-01 00:00:00

  • Familial achalasia of the esophagus in mother and son: a possible pathogenetic relationship.

    abstract::Familial achalasia most often has been recorded in siblings, and only rarely (twice previously) in a parent and offspring. This report concerns a third case of achalasia in a parent and offspring (mother and son). Clinical and radiographic features of the esophageal achalasia are presented. The possibility that geneti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1979.tb01741.x

    authors: Chawla K,Chawla SK,Alexander LL

    更新日期:1979-11-01 00:00:00

  • Fighting against age discrimination in clinical trials.

    abstract::At the American Geriatrics Society 2008 Annual Meeting, representatives of two geriatric societies, the European Union Geriatric Medicine Societies and the American Geriatrics Society, and two regulatory agencies, the U.S. Food and Drug Administration and the European Medicine Agency, conducted a roundtable discussion...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.2010.03032.x

    authors: Cherubini A,Del Signore S,Ouslander J,Semla T,Michel JP

    更新日期:2010-09-01 00:00:00

  • Cost-Effectiveness and Public Health Effect of Influenza Vaccine Strategies for U.S. Elderly Adults.

    abstract:OBJECTIVES:To compare the cost-effectiveness of four influenza vaccines available in the United States for persons aged 65 and older: trivalent inactivated influenza vaccine (IIV3), quadrivalent inactivated influenza vaccine (IIV4), a more-expensive high-dose IIV3, and a newly approved adjuvanted IIV3. DESIGN:Cost-eff...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.14323

    authors: Raviotta JM,Smith KJ,DePasse J,Brown ST,Shim E,Nowalk MP,Zimmerman RK

    更新日期:2016-10-01 00:00:00

  • An evaluative study of Silver's Cerebral Function Test.

    abstract::The aim of this study was to evaluate the usefulness of Silver's Cerebral Function Test in predicting the management and placement of patients admitted to a psychogeriatric hospital. Overall, 205 consecutively admitted patients and 54 age-matched controls living in the community were examined, thereby greatly extendin...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1977.tb00409.x

    authors: Ross N,de L Horne DJ

    更新日期:1977-06-01 00:00:00

  • Motor profile and drug treatment of nursing home residents with Parkinson's disease.

    abstract:OBJECTIVES:To examine the clinical characteristics, motor impairments, and drug treatments of nursing home residents with Parkinson's disease (PD). DESIGN:Cross-sectional study. SETTING:Nursing homes in the southeast of the Netherlands. PARTICIPANTS:Nursing home residents with PD and a Mini-Mental State Examination ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.12027

    authors: Weerkamp NJ,Zuidema SU,Tissingh G,Poels PJ,Munneke M,Koopmans RT,Bloem BR

    更新日期:2012-12-01 00:00:00

  • Self-Reported Hearing Status Is Associated with Lower Limb Physical Performance, Perceived Mobility, and Activities of Daily Living in Older Community-Dwelling Men and Women.

    abstract:OBJECTIVES:To explore the associations between self-reported hearing problems and physical performance and self-reported difficulties in mobility and activities of daily living (ADLs) in community-dwelling older adults. DESIGN:Cross-sectional cohort study. SETTING:Community. PARTICIPANTS:Men and women aged 75 to 90 ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.13381

    authors: Mikkola TM,Polku H,Portegijs E,Rantakokko M,Rantanen T,Viljanen A

    更新日期:2015-06-01 00:00:00

  • Red blood cell glucose-6-phosphate dehydrogenase activity in aged humans.

    abstract::The enzyme glucose-6-phosphate dehydrogenase (G6PD) was assayed in the circulating erythrocytes of 38 20-to 30-year-old subjects and 29 80- to 90-year-old subjects. The red blood cell G6PD activity of an aged-unbiased erythrocyte population in the young group was found to be significantly higher than in the older grou...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1983.tb06281.x

    authors: Rodgers GP,Lichtman HC,Sheff MF

    更新日期:1983-01-01 00:00:00

  • A Randomized Clinical Trial of Wheeled Mobility for Pressure Injury Prevention and Better Function.

    abstract:OBJECTIVES:To evaluate the effectiveness of wheelchair assessment and configuration on pressure injury incidence, mobility, and functioning in a wheelchair. DESIGN:Randomized controlled trial with participants individually randomized into intervention and control groups. SETTING:Nursing home. PARTICIPANTS:Nursing ho...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,随机对照试验

    doi:10.1111/jgs.15495

    authors: Brienza DM,Karg PE,Bertolet M,Schmeler M,Poojary-Mazzotta P,Vlachos H,Wilkinson D

    更新日期:2018-09-01 00:00:00

  • Ear lobe creases and heart disease.

    abstract::In 50 patients with coronary heart disease (CHD) and 38 controls, comparative data on age, sex, serum cholesterol level, hypertension, obesity, diabetes, smoking habits, and ear-lobe creases were analyzed statistically. After adjustment for age differences, the factors which chiefly distinguished the two groups were t...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1977.tb00290.x

    authors: Doering C,Ruhsenberger C,Phillips DS

    更新日期:1977-04-01 00:00:00

  • Findings and risk factors of early mortality of endoscopic retrograde cholangiopancreatography in different cohorts of elderly patients.

    abstract:OBJECTIVES:To analyze experience of endoscopic retrograde cholangiopancreatography (ERCP) in patients with of different age cohorts and discuss the risk factors of early mortality after ERCP. DESIGN:Retrospective study. SETTING:Tertiary care medical center. PARTICIPANTS:Two hundred sixty-four patients with pancreato...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2009.02477.x

    authors: Hu KC,Chang WH,Chu CH,Wang HY,Lin SC,Wang TE,Shih SC

    更新日期:2009-10-01 00:00:00

  • Nurses' and physicians' attitudes toward tube-feeding decisions in long-term care.

    abstract::We studied attitudes of health professionals toward life-sustaining treatment. A patient management questionnaire sent to staff physicians and nurses in 183 Oregon nursing homes consisted of eight patient sketches which varied age, mental status, and enjoyment of life. Respondents were asked whether they would favor t...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1986.tb05767.x

    authors: Watts DT,Cassel CK,Hickam DH

    更新日期:1986-08-01 00:00:00

  • Cause of Death and End-of-Life Experiences in Individuals with Dementia with Lewy Bodies.

    abstract:OBJECTIVES:To investigate the natural history, cause of death, and end-of-life experiences of individuals diagnosed with dementia with Lewy bodies (DLB). DESIGN:Twenty-question online survey administered through the Lewy Body Dementia Association. SETTING:United States. PARTICIPANTS:Caregivers, family, and friends o...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15608

    authors: Armstrong MJ,Alliance S,Corsentino P,DeKosky ST,Taylor A

    更新日期:2019-01-01 00:00:00

  • Methicillin-resistant Staphylococcus aureus colonization is associated with higher mortality in nursing home residents with impaired cognitive status.

    abstract:OBJECTIVES:To assess the effect of methicillin-resistant Staphylococcus aureus (MRSA) colonization on morbidity and mortality of nursing home residents. DESIGN:Three-year cohort study from 2000 to 2003. SETTING:Twenty-three nursing homes of all types and regions in the northern part of Belgium (Flanders). PARTICIPAN...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/j.1532-5415.2006.00972.x

    authors: Suetens C,Niclaes L,Jans B,Verhaegen J,Schuermans A,Van Eldere J,Buntinx F

    更新日期:2006-12-01 00:00:00

  • Older women and HIV: how much do they know and where are they getting their information?

    abstract:OBJECTIVES:To assess older urban women's knowledge about sexual transmission of human immunodeficiency virus (HIV)/acquired immune deficiency syndrome (AIDS) and to evaluate the relationship between their HIV/AIDS knowledge level and sources of information. DESIGN:Cross-sectional survey conducted between June 2001 and...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2004.52421.x

    authors: Henderson SJ,Bernstein LB,George DM,Doyle JP,Paranjape AS,Corbie-Smith G

    更新日期:2004-09-01 00:00:00

  • Predictors of mortality in older patients following medical intensive care: the importance of functional status.

    abstract:OBJECTIVE:We examined predictors of hospital and 6-month mortality in older Medical Intensive Care Unit (MICU) patients with particular attention to age and functional status. Age is generally thought to be strongly associated with intensive care outcomes, but this relationship may be confounded by age-related changes....

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1991.tb04452.x

    authors: Mayer-Oakes SA,Oye RK,Leake B

    更新日期:1991-09-01 00:00:00

  • Individual sulfonylureas and serious hypoglycemia in older people.

    abstract:OBJECTIVE:To compare the risk of serious hypoglycemia associated with the use of individual sulfonylureas in older people. DESIGN:A retrospective cohort study. SETTING:The Tennessee Medicaid Program. PATIENTS:A total of 13,963 Medicaid enrollees, aged 65 years or older, who were prescribed one of six sulfonylureas f...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1996.tb03729.x

    authors: Shorr RI,Ray WA,Daugherty JR,Griffin MR

    更新日期:1996-07-01 00:00:00

  • The timing hypothesis and hormone replacement therapy: a paradigm shift in the primary prevention of coronary heart disease in women. Part 1: comparison of therapeutic efficacy.

    abstract::The long-held belief that outcome data from intervention trials in men are generalizable to women has created the framework in which the primary prevention of coronary heart disease (CHD) in women is viewed, but over the past decade, data have accumulated to refute such a supposition of generalizability. These lines o...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/jgs.12140

    authors: Hodis HN,Mack WJ

    更新日期:2013-06-01 00:00:00

  • A comparison by payor/provider type of the cost of dying among frail older adults.

    abstract:OBJECTIVE:To compare expenditures and healthcare service use between decedents (in their last year of life) and survivors, all of whom were frail older people, under three payor/provider types. DESIGN:In-home interviews were conducted by home care nurses at baseline and at 6-month intervals for an 18-month period. Uti...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1996.tb02947.x

    authors: Experton B,Ozminkowski RJ,Branch LG,Li Z

    更新日期:1996-09-01 00:00:00

  • Neurotransmitter deficits in Alzheimer's disease: criteria for significance.

    abstract::A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter-deficiency syndrome, Parkinson's disease, validates these criteria. The major ...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,评审

    doi:10.1111/j.1532-5415.1983.tb04877.x

    authors: Greenwald BS,Mohs RC,Davis KL

    更新日期:1983-05-01 00:00:00

  • Serum thyrotropin and thyroid hormone levels in elderly and middle-aged euthyroid persons.

    abstract:OBJECTIVE:To determine whether serum thyrotropin (TSH) levels are altered in euthyroid older persons compared with middle-aged adults. DESIGN:Serum TSH and thyroid hormone levels were measured in a large group of older persons (> 70 years old, n = 216) and their middle-aged offspring (40-60 years old, n = 211) after e...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1993.tb06177.x

    authors: Hershman JM,Pekary AE,Berg L,Solomon DH,Sawin CT

    更新日期:1993-08-01 00:00:00

  • Serum vitamin B12 levels and incidence of dementia in a healthy elderly population: a report from the Bronx Longitudinal Aging Study.

    abstract:OBJECTIVE:To determine whether low serum B12 levels are associated with an increased incidence of dementing illness. DESIGN:Longitudinal cohort study, 5-year follow-up. PARTICIPANTS:Volunteer cohort of 410 nondemented ambulatory subjects aged 75 to 85 years. MEASUREMENTS:Annual serum B12 determinations and neuropsyc...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1994.tb06583.x

    authors: Crystal HA,Ortof E,Frishman WH,Gruber A,Hershman D,Aronson M

    更新日期:1994-09-01 00:00:00

  • Critically ill elderly adults with infection: analysis of the extended prevalence of infection in intensive care study.

    abstract:OBJECTIVES:To determine the effect of age on patterns of infection and on outcomes in individuals with infection. DESIGN:Analysis of data from an international, observational, point-prevalence study: Extended Prevalence of Infection in Intensive Care (EPIC II). SETTING:Intensive care units (ICUs; N=1,265) in 75 count...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章,多中心研究

    doi:10.1111/jgs.12544

    authors: Dimopoulos G,Koulenti D,Blot S,Sakr Y,Anzueto A,Spies C,Violán JS,Kett D,Armaganidis A,Martin C,Vincent JL,Extended Prevalence of Infection in Intensive Care Study Investigators.

    更新日期:2013-12-01 00:00:00

  • The Competing Risk of Death in Longitudinal Geriatric Outcomes.

    abstract:OBJECTIVES:To address the competing risk of death in longitudinal studies of older persons, we demonstrate sensitivity analyses that evaluate robustness of associations between exposures and three outcome types: dichotomous, count, and time to event. DESIGN:A secondary analysis of data from a prospective cohort study....

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15697

    authors: Murphy TE,Gill TM,Leo-Summers LS,Gahbauer EA,Pisani MA,Ferrante LE

    更新日期:2019-02-01 00:00:00

  • Sarcopenia Definition & Outcomes Consortium Defined Low Grip Strength in Two Cross-Sectional, Population-Based Cohorts.

    abstract:BACKGROUND/OBJECTIVES:The extent to which the prevalence of muscle weakness in the US population varies by different putative grip strength constructs developed by the Sarcopenia Definitions and Outcomes Consortium (SDOC) has not been described. DESIGN:Cross-sectional analysis. SETTING:Two nationally representative c...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.16419

    authors: Patel SM,Duchowny KA,Kiel DP,Correa-de-Araujo R,Fielding RA,Travison T,Magaziner J,Manini T,Xue QL,Newman AB,Pencina KM,Santanasto AJ,Bhasin S,Cawthon PM

    更新日期:2020-07-01 00:00:00

  • Agile Implementation: A Blueprint for Implementing Evidence-Based Healthcare Solutions.

    abstract:OBJECTIVES:To describe the essential components of an Agile Implementation (AI) process, which rapidly and effectively implements evidence-based healthcare solutions, and present a case study demonstrating its utility. DESIGN:Case demonstration study. SETTING:Integrated, safety net healthcare delivery system in India...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/jgs.15283

    authors: Boustani M,Alder CA,Solid CA

    更新日期:2018-07-01 00:00:00

  • Septic arthritis in patients aged 80 and older: a comparison with younger adults.

    abstract:OBJECTIVES:To compare the frequency and characteristics of septic arthritis in patients younger than 80 and aged 80 and older. DESIGN:Retrospective. SETTING:Single hospital center. PARTICIPANTS:Patients admitted between 1979 and 2002 for septic arthritis. MEASUREMENTS:Age, sex, time to diagnosis, predisposing facto...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2005.53373.x

    authors: Gavet F,Tournadre A,Soubrier M,Ristori JM,Dubost JJ

    更新日期:2005-07-01 00:00:00

  • Perception of poor health in the healthy older adult.

    abstract::A survey of 977 community subjects aged 65 or older identified 719 of them as not impaired in physical health. Of these, 104 (14 percent) perceived their physical status to be poor, whereas 615 (86 percent) accurately perceived it to be unimpaired. There were no significant differences between the two groups with rega...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.1979.tb06051.x

    authors: Blazer DG 2nd,Houpt JL

    更新日期:1979-07-01 00:00:00

  • Ethnic differences in Singapore's dementia prevalence: the stroke, Parkinson's disease, epilepsy, and dementia in Singapore study.

    abstract:OBJECTIVES:To study the prevalence of dementia in Singapore among Chinese, Malays, and Indians. DESIGN:A two-phase, cross-sectional study of randomly selected population from central Singapore with disproportionate race stratification. SETTING:Community-based study. Subjects screened to have cognitive impairment at p...

    journal_title:Journal of the American Geriatrics Society

    pub_type: 杂志文章

    doi:10.1111/j.1532-5415.2008.01992.x

    authors: Sahadevan S,Saw SM,Gao W,Tan LC,Chin JJ,Hong CY,Venketasubramanian N

    更新日期:2008-11-01 00:00:00