Fighting against age discrimination in clinical trials.

abstract：:Thirty-two patients entered a simple-blind, cross-over study on the action of tocopherol in osteoarthritis; only 3 did not complete the course. Each patient was randomly assigned either to the tocopherol group (600 mg/day for 10 days) or to the placebo group. After 10 days the groups were transposed. The analgesic and...

journal_title：Journal of the American Geriatrics Society

authors： Machtey I,Ouaknine L

更新日期：1978-07-01 00:00:00

abstract：OBJECTIVES:To examine cross-national care and outcomes related to end-of-life experiences. DESIGN:Postdeath interviews and self-administered questionnaires completed with family caregivers of residents with dementia who died in long-term care settings or shortly after transfer. SETTING:One hundred eighty-three nursin...

journal_title：Journal of the American Geriatrics Society

authors： Cohen LW,van der Steen JT,Reed D,Hodgkinson JC,van Soest-Poortvliet MC,Sloane PD,Zimmerman S

更新日期：2012-02-01 00:00:00

abstract：:An operational definition of frailty is important for clinical care, research, and policy planning. The literature on the clinical definitions, screening tools, and severity measures of frailty were systematically reviewed as part of the Canadian Initiative on Frailty and Aging. Searches of MEDLINE from 1997 to 2009 w...

journal_title：Journal of the American Geriatrics Society

authors： Sternberg SA,Wershof Schwartz A,Karunananthan S,Bergman H,Mark Clarfield A

更新日期：2011-11-01 00:00:00

abstract：OBJECTIVES:To determine how do-not-hospitalize (DNH) orders are interpreted and used in nursing homes (NHs) once they are in place. DESIGN:Qualitative study using in-depth semi-structured interviews performed from December 2013 to April 2014. SETTING:Eight skilled nursing facilities in Connecticut that ranked in the ...

journal_title：Journal of the American Geriatrics Society

authors： Cohen AB,Knobf MT,Fried TR

更新日期：2017-07-01 00:00:00

abstract：BACKGROUND:Hospital-acquired disability (HAD) is common and often related to low physical activity while in the hospital. OBJECTIVE:To examine whether wearable hospital activity trackers can be used to predict HAD. DESIGN:A prospective observational study between January 2016 and March 2017. SETTING:An academic medi...

journal_title：Journal of the American Geriatrics Society

authors： Pavon JM,Sloane RJ,Pieper CF,Colón-Emeric CS,Cohen HJ,Gallagher D,Hall KS,Morey MC,McCarty M,Hastings SN

更新日期：2020-02-01 00:00:00

abstract：OBJECTIVE:To determine factors that predict change in walking velocity in older people using a multivariate model. DESIGN:Longitudinal observational study. SUBJECTS:A total of 588 persons older than age 60, including subjects residing in a continuing care retirement community (CCRC) (n = 248), and homebound (n = 79) ...

journal_title：Journal of the American Geriatrics Society

authors： Gibbs J,Hughes S,Dunlop D,Singer R,Chang RW

更新日期：1996-02-01 00:00:00

abstract：:The case report presented is clinically compatible with late onset HD. The diagnosis was initially obscured by a lack of family history due to the early death of both parents and siblings. The presence of symptoms at the age of 59 in one offspring is consistent with the intrafamilial transmission of late onset HD dise...

journal_title：Journal of the American Geriatrics Society

authors： Moss RJ,Mastri AR,Schut LJ

更新日期：1988-03-01 00:00:00

abstract：OBJECTIVES:To determine the prevalence of depression in a cohort of elderly men as assessed using a 30-item Geriatric Depression Scale (GDS) score and to describe the association between this score and sex steroids, androgen receptor (AR) polymorphism, and general health status. DESIGN:Observational study on the relat...

journal_title：Journal of the American Geriatrics Society

authors： T'Sjoen GG,De Vos S,Goemaere S,Van Pottelbergh I,Dierick M,Van Heeringen C,Kaufman JM

更新日期：2005-04-01 00:00:00

abstract：:The objectives of this study were to examine the prevalence of assistive technology (AT) use, type of assistance used for each activity of daily living (ADL) limitation, and correlates of AT use among Native Indian aged 55 and older. Data were collected as part of a cross-sectional study of disability with 505 members...

journal_title：Journal of the American Geriatrics Society

authors： Goins RT,Spencer SM,Goli S,Rogers JC

更新日期：2010-11-01 00:00:00

abstract：OBJECTIVES:To provide descriptive epidemiological information on identified depression in nursing home residents. DESIGN:Survey of the 1996 Medical Expenditure Panel Survey-Nursing Home Component (MEPS-NHC). SETTING:Nine hundred fifty-one nursing facilities. PARTICIPANTS:Three thousand seven hundred ten noncomatose ...

journal_title：Journal of the American Geriatrics Society

authors： Jones RN,Marcantonio ER,Rabinowitz T

更新日期：2003-10-01 00:00:00

abstract：OBJECTIVE:To investigate the prevalence of and indications for digoxin use and the prevalence of beta blocker and calcium channel blocker use in older patients with previous myocardial infarction or coronary artery disease (CAD), and the prevalence of use of diuretics, beta blockers, angiotensin-converting enzyme (ACE)...

journal_title：Journal of the American Geriatrics Society

authors： Fishkind D,Paris BE,Aronow WS

更新日期：1997-07-01 00:00:00

abstract：:To better understand declining autopsy rates, data have been gathered prospectively on 1080 consecutive deaths over six years among patients admitted to a medical intensive care/coronary care unit. Overall autopsy rate was 36%. Autopsy rates declined sharply with age from 60% for those aged 16 to 34 years to 23% for t...

journal_title：Journal of the American Geriatrics Society

authors： Campion EW,Reder VA,Mulley AG,Thibault GE

更新日期：1986-12-01 00:00:00

abstract：OBJECTIVES:To improve screening for Alzheimer's disease (AD) with the Memory Impairment Screen (MIS), a 4-minute, four-item delayed free and cued recall memory test with controlled learning and high discriminative validity. To assess the discriminative validity of the MIS for AD and to compare it with the conventional ...

journal_title：Journal of the American Geriatrics Society

authors： Kuslansky G,Buschke H,Katz M,Sliwinski M,Lipton RB

更新日期：2002-06-01 00:00:00

abstract：OBJECTIVE:To determine how physical activity at various ages over the life course is associated with cognitive impairment in late life. DESIGN:Cross-sectional study. SETTING:Four U.S. sites. PARTICIPANTS:Nine thousand three hundred forty-four women aged 65 and older (mean 71.6) who self-reported teenage, age 30, age...

journal_title：Journal of the American Geriatrics Society

authors： Middleton LE,Barnes DE,Lui LY,Yaffe K

更新日期：2010-07-01 00:00:00

abstract：OBJECTIVES:To evaluate the association between insulin resistance (IR) and executive dysfunction in a large, population-based study of older persons without diabetes mellitus (DM) or dementia. DESIGN:Cross-sectional study. SETTING:Outpatient clinic in Greve in Chianti and Bagno a Ripoli, Italy. PARTICIPANTS:A total ...

journal_title：Journal of the American Geriatrics Society

authors： Abbatecola AM,Paolisso G,Lamponi M,Bandinelli S,Lauretani F,Launer L,Ferrucci L

更新日期：2004-10-01 00:00:00

abstract：BACKGROUND/OBJECTIVE:The benefits and harms of screening of Alzheimer disease and related dementias (ADRDs) are unknown. This study addressed the question of whether the benefits outweigh the harms of screening for ADRDs among older adults in primary care. DESIGN, SETTING, AND PARTICIPANTS:Single-blinded, two-arm, ran...

journal_title：Journal of the American Geriatrics Society

authors： Fowler NR,Perkins AJ,Gao S,Sachs GA,Boustani MA

更新日期：2020-03-01 00:00:00

abstract：BACKGROUND/OBJECTIVES:Recently revised vaccination recommendations for US adults, aged 65 years and older, include both 23-valent pneumococcal polysaccharide vaccine (PPSV23) and 13-valent pneumococcal conjugate vaccine (PCV13), with PCV13 now recommended for immunocompetent older people based on shared decision making...

journal_title：Journal of the American Geriatrics Society

authors： Wateska AR,Nowalk MP,Lin CJ,Harrison LH,Schaffner W,Zimmerman RK,Smith KJ

更新日期：2020-06-01 00:00:00

abstract：OBJECTIVES:To assess the complex interaction of apolipoprotein (apo) E polymorphisms and environmental factors on lipoprotein profile in centenarians. DESIGN:Cross-sectional analysis. SETTING:Tokyo metropolitan area. PARTICIPANTS:Seventy-five centenarians and 73 healthy older volunteers (mean age 63.1 +/- 10.0) livi...

journal_title：Journal of the American Geriatrics Society

authors： Arai Y,Hirose N,Nakazawa S,Yamamura K,Shimizu K,Takayama M,Ebihara Y,Osono Y,Homma S

更新日期：2001-11-01 00:00:00

abstract：OBJECTIVE:Based on the Canadian Study of Health and Aging (CSHA), to determine the importance of cognitive status, sociodemographic factors, functional status, and other health related factors as predictors of 5-year overall mortality in older Canadians. DESIGN, SETTING AND PARTICIPANTS:Two partially overlapping group...

journal_title：Journal of the American Geriatrics Society

authors： Ostbye T,Steenhuis R,Wolfson C,Walton R,Hill G

更新日期：1999-10-01 00:00:00

abstract：OBJECTIVE:To create a program to identify preventive needs for community-dwelling older persons and incorporate intervention strategies to improve implementation of these services. DESIGN:Program development and case-series. SETTING:Community-based meal sites, academically administered program. PARTICIPANTS:Persons ...

journal_title：Journal of the American Geriatrics Society

authors： Reuben DB,Hirsch SH,Frank JC,Maly RC,Schlesinger MS,Weintraub N,Yancey S

更新日期：1996-11-01 00:00:00

abstract：:Arguments have been made that the culture of nursing homes (NHs) must change to improve the quality of care, and two initiatives have been designed to accomplish this goal. One initiative is to provide resident outcome information (quality indicators) to NH management and consumers via public reporting systems. This i...

journal_title：Journal of the American Geriatrics Society

authors： Schnelle JF,Bates-Jensen BM,Chu L,Simmons SF

更新日期：2004-08-01 00:00:00

abstract：BACKGROUND:Coronary artery calcification (CAC) reflects the extent of coronary artery atherosclerosis. The extent of coronary artery calcification is not well described in older adults. OBJECTIVE:To determine the extent of CAC in older adults participating in a large population study of cardiovascular disease (CVD), e...

journal_title：Journal of the American Geriatrics Society

authors： Newman AB,Naydeck B,Sutton-Tyrrell K,Edmundowicz D,Gottdiener J,Kuller LH

更新日期：2000-03-01 00:00:00

abstract：OBJECTIVES:To investigate the cause of worse survival in older patients after myocardial infarction (MI). DESIGN:Prospective 18-month and longer follow-up study of a cohort of 167 patients (mean age +/- standard deviation 58 +/- 12, including 71 aged >or=65) with acute MI for cardiac events, defined as cardiac death, ...

journal_title：Journal of the American Geriatrics Society

authors： Smart S,Sagar K,Tresch D

更新日期：2002-07-01 00:00:00

abstract：OBJECTIVE:To assess the validity of several equations for estimating creatinine clearance in a large sample of high-functioning, community-dwelling elderly. DESIGN:Serum and 12-hour urine samples were collected and assayed for creatinine using the Jaffe total chromagen method. Fifteen clearance-estimating equations we...

journal_title：Journal of the American Geriatrics Society

authors： Malmrose LC,Gray SL,Pieper CF,Blazer DG,Rowe JW,Seeman TE,Albert MS

更新日期：1993-07-01 00:00:00

abstract：:The initial assessments of cognitive, psychologic, and behavioral functioning of 17 adults enrolled in a day care program for victims of Alzheimer's disease are described. These evaluations by the staff, the patients themselves, and their primary caregivers made use of standardized quantitative measures, thus permitti...

journal_title：Journal of the American Geriatrics Society

authors： Winogrond IR,Fisk AA

更新日期：1983-12-01 00:00:00

abstract：OBJECTIVE:To describe the evaluation of an interdisciplinary comprehensive geriatric assessment (CGA) consultation program for targeted hospitalized patients. DESIGN:Multi-center randomized clinical trial (RCT) at four hospitals where patients were randomly assigned to CGA consultation or usual care by the attending p...

journal_title：Journal of the American Geriatrics Society

authors： Borok GM,Reuben DB,Zendle LJ,Ershoff DH,Wolde-Tsadik G,Rubenstein LZ,Ambrosini VL,Fishman LK,Beck JC

更新日期：1994-05-01 00:00:00

abstract：OBJECTIVES:Measurements of health-related quality of life (HRQL) are an essential component in overall assessment of health status, particularly in older patients. Nevertheless, how measures of HRQL relate to measures of disease severity is largely unexplored. This study was carried out to explore the relationship betw...

journal_title：Journal of the American Geriatrics Society

authors： Ferrucci L,Baldasseroni S,Bandinelli S,de Alfieri W,Cartei A,Calvani D,Baldini A,Masotti G,Marchionni N

更新日期：2000-11-01 00:00:00

abstract：OBJECTIVES:To systematically review the current literature on the pharmacological treatment of postmeal reductions in blood pressure (BP). DESIGN:A systematic literature search and standardized data collection of randomized controlled trials on the pharmacological prevention of postprandial reductions in BP in adults ...

journal_title：Journal of the American Geriatrics Society

authors： Ong AC,Myint PK,Potter JF

更新日期：2014-04-01 00:00:00

abstract：OBJECTIVES:To describe longitudinal changes in the prevalence of major cardiovascular disease (CVD) risk factors in aging American Indians. DESIGN:Population-based ongoing epidemiological study. SETTING:The Strong Heart Study is a study of CVD and its risk factors. Standardized examinations were repeated in 1993 to 1...

journal_title：Journal of the American Geriatrics Society

authors： Rhoades DA,Welty TK,Wang W,Yeh F,Devereux RB,Fabsitz RR,Lee ET,Howard BV

更新日期：2007-01-01 00:00:00

abstract：:The course of untreated mild hypothyroidism was followed in 67 nursing home residents (mean age 78 years). The diagnosis was based on a normal free thyroxine index (FTI) and elevated thyrotropin concentration (TSH 4.6 to 15.0 microIU/mL, nl less than or equal to 4.5 microIU/mL. FTI and FSH were measured in follow-up 4...

journal_title：Journal of the American Geriatrics Society

authors： Drinka PJ,Nolten WE,Voeks SK,Langer EH

更新日期：1991-03-01 00:00:00