Neurotransmitter deficits in Alzheimer's disease: criteria for significance.

Abstract:

:A series of histopathologic, morphologic, and pharmacologic criteria are proposed to establish the significance of neurochemical deficits in Alzheimer's disease. The underlying pathogenic biochemistry of a better understood neurotransmitter-deficiency syndrome, Parkinson's disease, validates these criteria. The major neurotransmitter systems are evaluated against these guidelines. Only the cholinergic system fulfills all the criteria. Noradrenergic mechanisms are also implicated. Subsequent neurochemical abnormalities found in the brains of patients with Alzheimer's disease can be evaluated against these criteria.

journal_name

J Am Geriatr Soc

authors

Greenwald BS,Mohs RC,Davis KL

doi

10.1111/j.1532-5415.1983.tb04877.x

subject

Has Abstract

pub_date

1983-05-01 00:00:00

pages

310-6

issue

5

eissn

0002-8614

issn

1532-5415

journal_volume

31

pub_type

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