Abstract:
OBJECTIVES:To investigate the effectiveness of an exercise program in improving ability to perform activities of daily living (ADLs), physical performance, and nutritional status and decreasing behavioral disturbance and depression in patients with Alzheimer's disease (AD). DESIGN:Randomized, controlled trial. SETTING:Five nursing homes. PARTICIPANTS:One hundred thirty-four ambulatory patients with mild to severe AD. INTERVENTION:Collective exercise program (1 hour, twice weekly of walk, strength, balance, and flexibility training) or routine medical care for 12 months. MEASUREMENTS:ADLs were assessed using the Katz Index of ADLs. Physical performance was evaluated using 6-meter walking speed, the get-up-and-go test, and the one-leg-balance test. Behavioral disturbance, depression, and nutritional status were evaluated using the Neuropsychiatric Inventory, the Montgomery and Asberg Depression Rating Scale, and the Mini-Nutritional Assessment. For each outcome measure, the mean change from baseline to 12 months was calculated using intention-to-treat analysis. RESULTS:ADL mean change from baseline score for exercise program patients showed a slower decline than in patients receiving routine medical care (12-month mean treatment differences: ADL=0.39, P=.02). A significant difference between the groups in favor of the exercise program was observed for 6-meter walking speed at 12 months. No effect was observed for behavioral disturbance, depression, or nutritional assessment scores. In the intervention group, adherence to the program sessions in exploratory analysis predicted change in ability to perform ADLs. No adverse effects of exercise occurred. CONCLUSION:A simple exercise program, 1 hour twice a week, led to significantly slower decline in ADL score in patients with AD living in a nursing home than routine medical care.
journal_name
J Am Geriatr Socjournal_title
Journal of the American Geriatrics Societyauthors
Rolland Y,Pillard F,Klapouszczak A,Reynish E,Thomas D,Andrieu S,Rivière D,Vellas Bdoi
10.1111/j.1532-5415.2007.01035.xsubject
Has Abstractpub_date
2007-02-01 00:00:00pages
158-65issue
2eissn
0002-8614issn
1532-5415pii
JGS1035journal_volume
55pub_type
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