Abstract：
:The published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP C3435T on the pharmacokinetics of cyclosporine; thus, the aim was to conduct a meta-analysis of significant magnitude to investigate the influence of SNP C3435T on the pharmacokinetics of cyclosporine. A literature search was conducted to locate the relevant papers by using the PubMed electronic source from 1997 and onwards. The pharmacokinetic parameters, including AUC(0-4), AUC(0-12), AUC(0-inf), C(max), CL/F and trough concentration (C(0)), were extracted and a meta-analysis was performed by using Stata version 9.1. A total of 14 papers concerning 1036 individuals were included in the meta-analysis. The overall results showed no major influence of SNP C3435T on the pharmacokinetic parameters, including AUC(0-4), AUC(0-inf), CL/F, C(max) and C(0), although AUC(0-12) was lower in subjects with CC genotype. A subanalysis by ethnic population showed that C(0) was lower in Caucasian individuals harbouring CC genotype. In conclusion, our meta-analysis of available studies has thus far failed to demonstrate a definitive correlation between the SNP C3435T in MDR1 gene and alterations in P-glycoprotein function that can result in altered pharmacokinetics of cyclosporine, although it was indicated in this meta-analysis that the carrier of CC genotype of the SNP C3435T of MDR1 had lower cyclosporine exposure presented as AUC(0-12) than those with at least one T allele. There seems to be ethnic differences in the relationship between the SNP C3435T of MDR1 and cyclosporine pharmacokinetics.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Jiang ZP,Wang YR,Xu P,Liu RR,Zhao XL,Chen FPdoi
10.1111/j.1742-7843.2008.00300.xsubject
Has Abstractpub_date
2008-11-01 00:00:00pages
433-44issue
5eissn
1742-7835issn
1742-7843pii
PTO300journal_volume
103pub_type
杂志文章,meta分析abstract：:We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these p...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12210
更新日期：2014-09-01 00:00:00
abstract：:Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, health...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12224
更新日期：2014-10-01 00:00:00
abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2004-01-01 00:00:00
abstract：:Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1111/bcpt.12330
更新日期：2015-05-01 00:00:00
abstract：:This MiniReview is focused on the nature of intercellular signalling along the endothelium that helps to co-ordinate blood flow control in vascular resistance networks. Vasodilation initiated by contracting skeletal muscle ascends from arterioles within the tissue to encompass resistance arteries upstream and thereby ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2011.00798.x
更新日期：2012-01-01 00:00:00
abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12327
更新日期：2015-04-01 00:00:00
abstract：:Epidemiological data have shown that methamphetamine (MA) abuse significantly increases the risk of developing pulmonary arterial hypertension (PAH). To investigate whether MA could induce PAH and its possible mechanism, rats were exposed daily to MA for 5 weeks in the absence or presence of fluoxetine. The results sh...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2012.00933.x
更新日期：2013-02-01 00:00:00
abstract：:Mildronate is a cardioprotective drug that improves cardiac function during ischaemia and functions by lowering l-carnitine concentration in body tissues and modulating myocardial energy metabolism. The aim of the present study was to characterise cardiovascular function and liver condition after long-term mildronate ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00461.x
更新日期：2009-12-01 00:00:00
abstract：:Microdialysis is a valuable tool to measure tissue responses. We hypothesized that skeletal muscle metabolism can be modulated by microdialysis applied drugs which alter cytosolic calcium concentration. With approval of the local animal care committee, the hind limbs of sacrificed male Sprague Dawley rats were perfuse...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_250.x
更新日期：2006-04-01 00:00:00
abstract：:We investigated the effects of (1,4)-alpha-D-glucan (alpha-DG), a novel immune stimulatory drug from Tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [IL]-1beta, IL-6, tumour necrosis factor-alpha [TNF-alpha], gamma-interferon [IFN-gamma] and IL-10) in the lung and spleen...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00447.x
更新日期：2009-11-01 00:00:00
abstract：:Our objective was to identify the cytochrome P450 (CYP) enzymes that metabolise pioglitazone and to examine the effects of the CYP2C8 inhibitors montelukast, zafirlukast, trimethoprim and gemfibrozil on pioglitazone metabolism in vitro. The effect of different CYP isoform inhibitors on the elimination of a clinically ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_437.x
更新日期：2006-07-01 00:00:00
abstract：:Latex allergy is important due to serious health impacts and widespread use of its products. Latex allergic reactions can be induced in skin and mucosal surfaces including the respiratory tract. The development of murine models of allergic airway inflammation has provided a framework to dissect out the cellular and mo...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_530.x
更新日期：2006-12-01 00:00:00
abstract：:The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents. Here, we report that among the six characterized SF-derived quinolizidine alkaloids including sophoridine...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00653.x
更新日期：2011-05-01 00:00:00
abstract：:The essential oil of Alpinia zerumbet (EOAz) presents myorelaxant and antispasmodic actions on cardiac and smooth muscles. The aim of this study was to investigate the effect of EOAz on the skeletal muscle contraction in post-stroke spasticity. Fifteen adults with unilateral hemiparesis and spasticity resulting from s...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章
doi：10.1111/bcpt.12439
更新日期：2016-01-01 00:00:00
abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1111/bcpt.12146
更新日期：2014-03-01 00:00:00
abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_188.x
更新日期：2006-01-01 00:00:00
abstract：:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12575
更新日期：2016-08-01 00:00:00
abstract：:Vitamin D deficiency seems to be implicated in the onset and progression of some autoimmune disorders. No previous study has investigated vitamin D homeostasis in post-partum thyroiditis. We compared 25-hydroxyvitamin D and parathyroid hormone (PTH) levels between four groups of non-lactating women who gave birth with...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12349
更新日期：2015-06-01 00:00:00
abstract：:Mesenchymal stem cells (MSCs) and MSC-derived small extracellular vesicles (sEVs) are promising candidates for cell-based and cell-free regenerative medicine, respectively. By virtue of their multiple lineage differentiation capacity, MSCs have been implicated as an ideal tool for bone and cartilage regeneration. Howe...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.13478
更新日期：2021-01-01 00:00:00
abstract：:The study was designed to assess blood platelet sensitivity to acetylsalicylic acid and its associations with dyslipidaemia and inflammation in coronary artery disease patients. Platelet non-responsiveness to aspirin is associated with an increased risk of serious cardiovascular events. Several environmental and hered...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_343.x
更新日期：2006-05-01 00:00:00
abstract：:In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspecti...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12946
更新日期：2018-05-01 00:00:00
abstract：:In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3A activity in healthy volunteers from Swe...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12230
更新日期：2014-10-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_533.x
更新日期：2006-11-01 00:00:00
abstract：:The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy in...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12644
更新日期：2017-01-01 00:00:00
abstract：:Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00421.x
更新日期：2009-09-01 00:00:00
abstract：:The post-injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60-year-old Caucasian, schizophrenic, non-smoker and underweight [body mass index (BMI), 18.2 kg/m(2) ] women after the fourth intramuscular injection of 405 mg olanzapine pamoate. Clinical symptoms of PDSS were similar to those of acute...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12394
更新日期：2015-09-01 00:00:00
abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.13456
更新日期：2020-12-01 00:00:00
abstract：:One of the most common risks after a heart transplant is bleeding. In this study, the effect of desmopressin administration on the amount of bleeding and transfusion requirements after heart transplant surgery was investigated. In a double-blind clinical trial, 48 patients who were candidates for heart transplant surg...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1111/bcpt.12780
更新日期：2017-09-01 00:00:00
abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2007.00130.x
更新日期：2007-11-01 00:00:00
abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12320
更新日期：2015-01-01 00:00:00
