Abstract：
:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto2 modulation is still unclear, gain-of-function results from the characterization of GluK1-GluA2 chimeras indicate that the GluK1 sequences included in these chimeras (part or all of the TMD and part of the linkers between the TMDs and LBD) play a key role in Neto2 modulation of KAR. In addition, GluK2 M3-S2 linkers and the D1-D1 dimer interface were also recently identified to be important for Neto2 modulation, and some studies suggested that Neto2's N-terminal regions, LDLa domain and the C-terminal regions are important for its modulation of KARs. Although more studies are needed to confirm the roles of these domains and to identify all the domains and residues essential for KAR modulation, these results facilitate our understanding of Neto2 modulation at the structural level, which could potentially aid the development of novel therapies for the treatment of diseases that are associated with KARs, for example epilepsies, non-syndromic autosomal recessive mental retardation, schizophrenia and bipolar disorder.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Han L,Howe JR,Pickering DSdoi
10.1111/bcpt.12575subject
Has Abstractpub_date
2016-08-01 00:00:00pages
141-8issue
2eissn
1742-7835issn
1742-7843journal_volume
119pub_type
杂志文章,评审abstract：:Hypotensive effects of oral sodium nitrite have been reported as alternative sources of nitric oxide (NO) formation in animals and human beings. Reductions in NO bioavailability were observed in lead-induced hypertension. However, no previous study has examined whether a single daily dose of sodium nitrite prevents th...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12480
更新日期：2016-03-01 00:00:00
abstract：:We investigated the effects of (1,4)-alpha-D-glucan (alpha-DG), a novel immune stimulatory drug from Tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [IL]-1beta, IL-6, tumour necrosis factor-alpha [TNF-alpha], gamma-interferon [IFN-gamma] and IL-10) in the lung and spleen...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00447.x
更新日期：2009-11-01 00:00:00
abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00468.x
更新日期：2009-12-01 00:00:00
abstract：:Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives of the present study were to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for simvastatin and to evaluate its usefulness in predicting the dose-response relationship of simvastatin...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2011.00700.x
更新日期：2011-09-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00648.x
更新日期：2011-04-01 00:00:00
abstract：:Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irino...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2007.00115.x
更新日期：2007-10-01 00:00:00
abstract：:Megestrol acetate, an appetite stimulant with low bioavailability, shows increased bioavailability when taken together with food. However, the pharmacokinetic characteristics of megestrol acetate and its relation with food are not well understood. This study aimed to investigate the food effect on the pharmacokinetics...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章
doi：10.1111/bcpt.12677
更新日期：2017-03-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12748
更新日期：2017-06-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1111/bcpt.12993
更新日期：2018-08-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2011.00786.x
更新日期：2012-01-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2007.00191.x
更新日期：2008-02-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00589.x
更新日期：2010-11-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12340
更新日期：2015-06-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2008.00286.x
更新日期：2008-09-01 00:00:00
abstract：:The present in vivo study investigated the genotoxicity of four dental resin monomers: triethyleneglycoldimethacrylate (TEGDMA), hydroxyethylmethacrylate (HEMA), urethanedimethacrylate (UDMA) and bisphenol A-glycidylmethacrylate (BisGMA). The Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster w...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00479.x
更新日期：2010-02-01 00:00:00
abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12289
更新日期：2015-02-01 00:00:00
abstract：:This study was undertaken in order to investigate a) the short- and long-term in vivo effects of cadmium (Cd) on brain acetylcholinesterase (AChE), (Na+, K+)-ATPase activities in adult rats, b) the concentration-dependent in vitro and in vivo (acute experiment) effects of Cd on the activity of those enzymes, c) the in...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2004.pto940303.x
更新日期：2004-03-01 00:00:00
abstract：:Pharmacokinetic/pharmacodynamic (PK/PD) models can be useful tools in new drug development and also optimal drug therapy in patients. This study was designed to develop a PK/PD model of sitagliptin based on the physiology of incretin. The PK/PD data included information derived from two different studies. Study 1 was ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12068
更新日期：2013-08-01 00:00:00
abstract：:Connective tissue growth factor (CTGF) plays a pathogenic role in diabetic nephropathy (DN). Rosmarinic acid (RA) is a naturally occurring phenolic acid. This study was conducted to investigate the efficacy of RA on DN and to elucidate the potential mechanism. High glucose (HG)-stimulated cultured human renal proximal...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2011.00828.x
更新日期：2012-04-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2012.00923.x
更新日期：2013-01-01 00:00:00
abstract：:Alzheimer's disease is a neurodegenerative disorder that is characterized by the accumulation of senile plaques containing amyloid β (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein in the brain. Oxidative stress has been proposed to mediate Aβ-induced neurotoxicity. In that regard, we eval...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00664.x
更新日期：2011-06-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00549.x
更新日期：2010-07-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12654
更新日期：2017-02-01 00:00:00
abstract：:Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice. The new benzofuranone 4 ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00441.x
更新日期：2009-10-01 00:00:00
abstract：:High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Cap...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.13211
更新日期：2019-08-01 00:00:00
abstract：:Cisplatin and other platinum complexes are important chemotherapeutic agents and useful in the treatment for several cancers such as prostate, ovarian and testis. However, severe side effects including reproductive toxicity of cisplatin and other platinum complex cause limitations in their clinical usage. In this cont...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2011.00737.x
更新日期：2011-11-01 00:00:00
abstract：:Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminif...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.13264
更新日期：2019-10-01 00:00:00
abstract：:The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents. Here, we report that among the six characterized SF-derived quinolizidine alkaloids including sophoridine...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00653.x
更新日期：2011-05-01 00:00:00
abstract：:The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid (TMCA) to reverse it. Reversal of liver fibrosis was studied in male Wistar rats after one, two or three months of CCl(...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2005.pto_06.x
更新日期：2005-05-01 00:00:00
abstract：:In previous studies we have reported that NQ301, a synthetic 1,4-naphthoquinone derivative, displays a potent antithrombotic activity, and that this might be due to antiplatelet effect, which was mediated by the inhibition of cytosolic Ca(2+) mobilization in activated platelets. In the present study, the effect of NQ3...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2005.pto_973123.x
更新日期：2005-09-01 00:00:00
