Mercury exposure and its effects on fertility and pregnancy outcome.

abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...

journal_title：Basic & clinical pharmacology & toxicology

authors： Almeida IF,Fernandes E,Lima JL,Costa PC,Bahia MF

更新日期：2009-10-01 00:00:00

abstract：:Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, poor metabolizers (PM) and the remainder with preserved CYP2D6 activity, extensive metabolizers ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zwisler ST,Enggaard TP,Noehr-Jensen L,Pedersen RS,Mikkelsen S,Nielsen F,Brosen K,Sindrup SH

更新日期：2009-04-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) has been connected to learning, memory and mood. Changes in serum or plasma POP activity have been linked to psychiatric disorders. POP has been thought to interfere in these conditions by cleaving neuroactive peptides or via the phosphatidylinositol second messenger system. However, little...

journal_title：Basic & clinical pharmacology & toxicology

authors： Peltonen I,Männistö PT

更新日期：2011-01-01 00:00:00

abstract：:Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of generalized vitiligo. Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that ca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lan WJ,Wang HY,Lan W,Wang KY

更新日期：2008-07-01 00:00:00

abstract：:Previous studies suggest that flavonol icariin protects against neuron injury after oxygen and glucose deprivation by increasing SIRT1. This study demonstrates that icariin can inhibit H(2) O(2) -induced neurotoxicity. The neuroprotection of icariin enhances the antioxidant capacity through both a direct scavenging ef...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang L,Huang S,Chen Y,Wang Z,Li E,Xu Y

更新日期：2010-11-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) is considered as the limiting enzyme of thiopurine metabolism for the formation of 6-thioguanine nucleotides (6-TGN). No data are available on the influence of RBC IMPDH activity on the metabolism of thiopurine drugs in individuals with IBD. The aims of this study were as fo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Citterio-Quentin A,El Mahmoudi A,Perret T,Conway A,Ryan A,Beringer A,Lachaux A,Boulieu R

更新日期：2019-05-01 00:00:00

abstract：:Substantial development in the pharmacological treatment for attention-deficit hyperactivity disorder (ADHD) has been made recently including approval of new non-stimulant agents targeting noradrenergic, histaminergic and dopaminergic systems. Among such, atomoxetine has been widely used, although its mechanism of act...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu LL,Yang J,Lei GF,Wang GJ,Wang YW,Sun RP

更新日期：2008-06-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used to treat acute pro-myelocytic leukaemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cellular membrane. Consistent with these findings, in this study...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao X,Shi YQ,Yan CC,Feng PF,Wang X,Zhang R,Zhang X,Li BX

更新日期：2015-06-01 00:00:00

abstract：BACKGROUND:It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate whether the effectiveness ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Møller Gundersen K,Nygaard Jensen J,Bjerrum L,Hansen MP

更新日期：2019-05-01 00:00:00

abstract：:Pain involves responses in which both peripheral and central mechanisms contribute to the generation of pain. Pre-clinical laboratory data have supported that a topical formulation of combined diclofenac and methadone (Diclometh) may alleviate local pain, and potentially, the side effect profile should be low. We hypo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Larsen IM,Drewes AM,Olesen AE

更新日期：2018-08-01 00:00:00

abstract：:One of the most common risks after a heart transplant is bleeding. In this study, the effect of desmopressin administration on the amount of bleeding and transfusion requirements after heart transplant surgery was investigated. In a double-blind clinical trial, 48 patients who were candidates for heart transplant surg...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jahangirifard A,Razavi MR,Ahmadi ZH,Forozeshfard M

更新日期：2017-09-01 00:00:00

abstract：:Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Graversen C,Malver LP,Kurita GP,Staahl C,Christrup LL,Sjøgren P,Drewes AM

更新日期：2015-05-01 00:00:00

abstract：:Doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. Selected...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wattanapitayakul SK,Chularojmontri L,Herunsalee A,Charuchongkolwongse S,Niumsakul S,Bauer JA

更新日期：2005-01-01 00:00:00

abstract：:Vitamin K antagonists (VKA) are highly effective anticoagulants but their use is hampered by multiple interactions with food and medicine and a narrow therapeutic range. The large variation in dose requirements has led to the development of several dosing algorithms based on pharmacogenetic and clinical variables. In ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Skov J,Bladbjerg EM,Rasmussen MA,Sidelmann JJ,Leppin A,Jespersen J

更新日期：2012-02-01 00:00:00

abstract：:Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinject...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cunha AO,Mortari MR,Liberato JL,dos Santos WF

更新日期：2009-06-01 00:00:00

abstract：:Since the introduction of antivenom administration over a century ago to treat venomous snake bite, it has been the most effective therapy for saving life and limb. However, this treatment is not always effective and not without potential life-threatening side effects. We tested a new paradigm to abrogate the plasmati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nielsen VG,Losada PA

更新日期：2017-02-01 00:00:00

abstract：:The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mogensen S,Sverrisdóttir E,Sveinsdóttir K,Treldal C,Jensen K,Jensen AB,Kristensen CA,Jacobsen J,Kreilgaard M,Petersen J,Andersen O

更新日期：2017-01-01 00:00:00

abstract：:The use of herbal or natural medicines for the treatment of various disorders has a long and extensive history. Many of these herbal medicines are finding their way onto the world market as alternatives to prescribed drugs currently available to treat various disorders/ailments. In particular, hyperlipidaemia is a maj...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang TH,Kota BP,Razmovski V,Roufogalis BD

更新日期：2005-01-01 00:00:00

abstract：:In view of paediatric drug development, regulatory authorities often request safety studies in juvenile animals, including minipigs. Unfortunately, knowledge on the ontogeny of the biotransformation processes in animal models remains scarce and impedes a correct interpretation of the toxicity findings. CYP3A4 is one o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Peer E,De Bock L,Boussery K,Van Bocxlaer J,Casteleyn C,Van Ginneken C,Van Cruchten S

更新日期：2015-11-01 00:00:00

abstract：:Young mice (2 weeks old) were given topiramate daily for 1 month, and sudomotor function was evaluated utilizing impression mould techniques to determine the number of sweat glands reactive to heat exposure and sweat output per gland on the plantar surface of mice hind-paws. Immunohistochemical quantitation of protein...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tian J,Huang Y,Deng Y,Chen J,Ma L,Chen X,Jiang W,Zhao G,Wang J

更新日期：2007-06-01 00:00:00

abstract：:The scope of the current study was to examine the possible effects of sulphated polysaccharides against cyclosporine A-induced glomerular injury. Nephrotoxicity induced by cyclosporine A continues to be a major problem despite its potent immunosuppressive action. Adult male albino rats of Wistar strain were categorize...

journal_title：Basic & clinical pharmacology & toxicology

authors： Josephine A,Veena CK,Amudha G,Preetha SP,Sundarapandian R,Varalakshmi P

更新日期：2007-07-01 00:00:00

abstract：:This study investigated the impact of prolonged nicotine administration on myocardial susceptibility to ischaemia-reperfusion (I/R) injury in a rat model and determined whether nicotine affects mitochondrial reactive oxygen species (ROS) production and permeability transition in rat hearts. Sprague-Dawley rats were ad...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ramalingam A,Mohd Fauzi N,Budin SB,Zainalabidin S

更新日期：2021-02-01 00:00:00

abstract：:In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang Y,Zhang H,Yang Z,Miao D,Zhang D

更新日期：2018-02-01 00:00:00

abstract：:In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspecti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pottegård A,Friis S,Stürmer T,Hallas J,Bahmanyar S

更新日期：2018-05-01 00:00:00

abstract：:Since the 1970s, we have known that aspirin can reduce the risk of pre-eclampsia. However, the underlying mechanisms explaining this risk reduction are poorly understood. Both cyclooxygenase (COX)-1- and COX-2-dependent effects might be involved. As a consequence of this knowledge hiatus, the optimal dose and timing o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mirabito Colafella KM,Neuman RI,Visser W,Danser AHJ,Versmissen J

更新日期：2020-08-01 00:00:00

abstract：:Pharmacokinetic/pharmacodynamic (PK/PD) models can be useful tools in new drug development and also optimal drug therapy in patients. This study was designed to develop a PK/PD model of sitagliptin based on the physiology of incretin. The PK/PD data included information derived from two different studies. Study 1 was ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim BH,Kim SE,Kang D,Lim KS,Kim JR,Jang IJ,Shin SG,Yoon SH,Cho JY,Yu KS

更新日期：2013-08-01 00:00:00

abstract：:This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang S,Tang X,Tian J,Li C,Zhang G,Jiang W,Zhang Z

更新日期：2011-06-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2008-05-01 00:00:00