Screening of antioxidants from medicinal plants for cardioprotective effect against doxorubicin toxicity.

abstract：:Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P,Abdennebi-Najar L,Barouki R,Cranor CF,Etzel RA,Gee D,Heindel JJ,Hougaard KS,Hunt P,Nawrot TS,Prins GS,Ritz B,Soffritti M,Sunyer J,Weihe P

更新日期：2019-08-01 00:00:00

abstract：:The cannabinoid 1 receptor antagonist AM 251 is known to block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. We examined the ability of AM 251 to inhibit sodium channel-dependent functions and the ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liao C,Zheng J,David LS,Nicholson RA

更新日期：2004-02-01 00:00:00

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:Substantial development in the pharmacological treatment for attention-deficit hyperactivity disorder (ADHD) has been made recently including approval of new non-stimulant agents targeting noradrenergic, histaminergic and dopaminergic systems. Among such, atomoxetine has been widely used, although its mechanism of act...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu LL,Yang J,Lei GF,Wang GJ,Wang YW,Sun RP

更新日期：2008-06-01 00:00:00

abstract：:Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irino...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jung GR,Kim KJ,Choi CH,Lee TB,Han SI,Han HK,Lim SC

更新日期：2007-10-01 00:00:00

abstract：:High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Cap...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen L,Xiong X,Hou X,Wei H,Zhai J,Xia T,Gong X,Gao S,Feng G,Tao X,Zhang F,Chen W

更新日期：2019-08-01 00:00:00

abstract：:Chemokines are chemotactic cytokines whose involvement in nociceptive processing is being increasingly recognized. Based on the previous description of the involvement of CC chemokine receptor type 1 (CCR1) in pathological pain, we have assessed the participation of CCR1 and its endogenous ligands CCL3 and CCL5 in hyp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Llorián-Salvador M,González-Rodríguez S,Lastra A,Fernández-García MT,Hidalgo A,Menéndez L,Baamonde A

更新日期：2016-07-01 00:00:00

abstract：:The aim is to emphasize the importance of extracardiac symptoms of digoxin intoxication in newborns. The most common intoxication symptoms in adults are of cardiac origin, but due to altered symptomatology, digoxin overdose in infants are not always discovered on symptomatic basis. In preterm infants, this is even mor...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nybo M,Damkier P

更新日期：2005-06-01 00:00:00

abstract：:Concurrent administration of chloramphenicol (CAP) with multivitamin-haematinics complex (MHC) is a common practice to cushioning anticipated anaemic effect of CAP in most developing countries. This study investigated the mechanism involved in CAP-induced reproductive toxicity as well as the effects of its co-administ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Oyagbemi AA,Adedara IA,Saba AB,Farombi EO

更新日期：2010-09-01 00:00:00

abstract：:The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid (TMCA) to reverse it. Reversal of liver fibrosis was studied in male Wistar rats after one, two or three months of CCl(...

journal_title：Basic & clinical pharmacology & toxicology

authors： Muriel P,Moreno MG,Hernández Mdel C,Chávez E,Alcantar LK

更新日期：2005-05-01 00:00:00

abstract：:The antithrombotic and antiplatelet activities of Korean red ginseng extract (KRGE) were examined on rat carotid artery thrombosis in vivo and platelet aggregation in vitro and ex vivo. The KRGE significantly prevented rat carotid arterial thrombosis in vivo in a dose-dependent manner. Administration of the KRGE to ra...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Yu JY,Lee JJ,You SH,Chung JH,Noh JY,Im JH,Han XH,Kim TJ,Shin KS,Wee JJ,Yun YP

更新日期：2007-03-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:The beneficial effects of kolaviron, a natural biflavonoid from the seeds of Garcinia kola, have been attributed mainly to its antioxidant and anti-inflammatory effects. This study investigated these effects on dextran sulphate sodium (DSS)-induced ulcerative colitis in rats. Sulfasalazine served as standard reference...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farombi EO,Adedara IA,Ajayi BO,Ayepola OR,Egbeme EE

更新日期：2013-07-01 00:00:00

abstract：:Gastric carcinoma (GC) is a pernicious neoplasm with high morbidity and mortality. Sinomenine (SIN) has long been exploited to heal rheumatoid arthritis. Recently, SIN has been discovered to exert the antitumour functions in diverse cancers. However, the impacts of SIN on GC remain indistinct. We attempted to expose t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yuan H,Zhang J,Li F,Li W,Wang H

更新日期：2019-11-01 00:00:00

abstract：:Vitamin D metabolism was studied in primary human dermal fibroblasts with focus on drug-mediated gene regulation related to adverse side effects of antiretroviral drugs used in HIV therapy. The fibroblasts expressed mRNA for cytochrome P450 (CYP) enzymes catalysing bioactivating (CYP2R1, CYP27A1 and CYP27B1) and catab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Norlin M,Lundqvist J,Ellfolk M,Hellström Pigg M,Gustafsson J,Wikvall K

更新日期：2017-01-01 00:00:00

abstract：:Opioids given to pregnant and parturient women are relatively freely transferred across the placenta. Spinal, epidural and intravenous fentanyl has been studied in pregnant women and neonates, but foetal safety of fentanyl dosing with transdermal patch during pregnancy and labour is not sufficiently studied. Foetal pH...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen EM,Kokki H,Heikkinen A,Ranta VP,Räsänen J,Voipio HM,Kokki M

更新日期：2017-02-01 00:00:00

abstract：:This study investigated the impact of prolonged nicotine administration on myocardial susceptibility to ischaemia-reperfusion (I/R) injury in a rat model and determined whether nicotine affects mitochondrial reactive oxygen species (ROS) production and permeability transition in rat hearts. Sprague-Dawley rats were ad...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ramalingam A,Mohd Fauzi N,Budin SB,Zainalabidin S

更新日期：2021-02-01 00:00:00

abstract：:Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant num...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lucafò M,Di Silvestre A,Romano M,Avian A,Antonelli R,Martelossi S,Naviglio S,Tommasini A,Stocco G,Ventura A,Decorti G,De Iudicibus S

更新日期：2018-01-01 00:00:00

abstract：:Young mice (2 weeks old) were given topiramate daily for 1 month, and sudomotor function was evaluated utilizing impression mould techniques to determine the number of sweat glands reactive to heat exposure and sweat output per gland on the plantar surface of mice hind-paws. Immunohistochemical quantitation of protein...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tian J,Huang Y,Deng Y,Chen J,Ma L,Chen X,Jiang W,Zhao G,Wang J

更新日期：2007-06-01 00:00:00

abstract：:Many compounds display anticholinergic effects which might give rise to cognitive impairment and even delirium. These side effects are caused by their ability to bind to muscarinic receptors in our brain. Especially with combination of compounds, these serious effects are seen. This phenomenon, known as anticholinergi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vrolijk MF,Opperhuizen A,Jansen EH,Bast A,Haenen GR

更新日期：2015-12-01 00:00:00

abstract：:In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspecti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pottegård A,Friis S,Stürmer T,Hallas J,Bahmanyar S

更新日期：2018-05-01 00:00:00

abstract：:We evaluated the effects of conjugated enzyme-nerve agent product resulting from the inhibition of bioscavenger human serum butyrylcholinesterase (Hu BChE) by nerve agents soman or VX. Rats were trained on a multiple Fixed-Ratio 32, Extinction 30 sec. (FR32, Ext30) schedule of food reinforcement and then injected (i.m...

journal_title：Basic & clinical pharmacology & toxicology

authors： Genovese RF,Sun W,Johnson CC,Ditargiani RC,Doctor BP,Saxena A

更新日期：2010-05-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kuca K,Cabal J,Jung YS,Musilek K,Soukup O,Jun D,Pohanka M,Musilova L,Karasová J,Novotný L,Hrabinova M

更新日期：2009-09-01 00:00:00

abstract：:Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, health...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saruwatari J,Takashima A,Yoshida K,Soraoka H,Ding TB,Uchiyashiki Y,Tsuda Y,Imamura M,Oniki K,Miyata K,Nakagawa K

更新日期：2014-10-01 00:00:00

abstract：:In the last decades, a number of new antimuscarinic drugs have been introduced for treatment of the overactive bladder (OAB), defined symptomatically (OAB syndrome) or urodynamically (detrusor overactivity). Recently, three new drug principles have been approved for clinical use, the β3 -adrenoceptor agonist, mirabegr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Andersson KE

更新日期：2016-10-01 00:00:00

abstract：:The decapeptide degarelix is a novel competitive gonadotropin-releasing hormone receptor antagonist that has been approved for the treatment of advanced prostate cancer by the FDA and the EU authorities. In this study, the interaction of degarelix with human cytochrome P450 (CYP450) enzymes was investigated in vitro. ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sonesson A,Rasmussen BB

更新日期：2011-09-01 00:00:00

abstract：:The potent neurotoxin saxitoxin (STX) belongs to a group of structurally related analogues produced by both marine and freshwater phytoplankton. The toxins act by blocking voltage-gated sodium channels stopping the inflow of sodium ions and the generation of action potentials. Exposure from marine sources occurs as a ...

journal_title：Basic & clinical pharmacology & toxicology

authors： O'Neill K,Musgrave IF,Humpage A

更新日期：2017-04-01 00:00:00

abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Möller J,Laflamme L,Söderberg Löfdal K

更新日期：2015-02-01 00:00:00

abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...

journal_title：Basic & clinical pharmacology & toxicology

authors： Faro LR,Alfonso M,Cervantes R,Durán R

更新日期：2009-12-01 00:00:00