Age-related Differences in CYP3A Abundance and Activity in the Liver of the Göttingen Minipig.

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang H,Ju B,Zhang X,Zhu Y,Nie Y,Xu Y,Lei Q

更新日期：2017-06-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:Although commonly associated with obesity, non-alcoholic fatty liver disease (NAFLD) is also present in the lean population representing a unique disease phenotype. Affecting 25% of the world's population, NAFLD is associated with increased mortality especially when progressed to non-alcoholic steatohepatitis (NASH). ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ipsen DH,Rolin B,Rakipovski G,Skovsted GF,Madsen A,Kolstrup S,Schou-Pedersen AM,Skat-Rørdam J,Lykkesfeldt J,Tveden-Nyborg P

更新日期：2018-12-01 00:00:00

abstract：:At the time that Paracelsus coined his famous dictum, 'What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison', embryonic toxicology was a fairly focused discipline that mainly dealt with occupational poisonings and side effects of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P

更新日期：2016-08-01 00:00:00

abstract：:Aripiprazole is an antipsychotic that acts as a partial agonist at dopamine receptors. As the effects of most drugs of abuse converge to enhance dopamine-mediated neurotransmission, the present study was designed to test the hypothesis that aripiprazole would inhibit the acute effects of ethanol, a widely abused subst...

journal_title：Basic & clinical pharmacology & toxicology

authors： Viana TG,Almeida-Santos AF,Aguiar DC,Moreira FA

更新日期：2013-05-01 00:00:00

abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

journal_title：Basic & clinical pharmacology & toxicology

authors： Iversen TZ,Andersen MH,Svane IM

更新日期：2015-01-01 00:00:00

abstract：:QF-036 is an HIV-1 maturation inhibitor in pre-clinical development, and its antiviral activity against a laboratory HIV-1 strain and two drug-resistant strains was determined in the C8166 line. QF-036 was also subjected to absorption, distribution and metabolism (ADM) assessment in vitro, and pharmacokinetic profiles...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao L,He HH,Ou-Yang T,Liu DF,Jiang CH,Yang HP,Wang P,Xie N,Yan SS

更新日期：2021-02-01 00:00:00

abstract：:In previous studies we have reported that NQ301, a synthetic 1,4-naphthoquinone derivative, displays a potent antithrombotic activity, and that this might be due to antiplatelet effect, which was mediated by the inhibition of cytosolic Ca(2+) mobilization in activated platelets. In the present study, the effect of NQ3...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Cho MR,Lee KS,Lee JJ,Lim Y,Han XH,Oh KW,Hong JT,Yoo HS,Yun YP

更新日期：2005-09-01 00:00:00

abstract：:Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kuca K,Cabal J,Jung YS,Musilek K,Soukup O,Jun D,Pohanka M,Musilova L,Karasová J,Novotný L,Hrabinova M

更新日期：2009-09-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:This MiniReview is focused on the nature of intercellular signalling along the endothelium that helps to co-ordinate blood flow control in vascular resistance networks. Vasodilation initiated by contracting skeletal muscle ascends from arterioles within the tissue to encompass resistance arteries upstream and thereby ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Socha MJ,Behringer EJ,Segal SS

更新日期：2012-01-01 00:00:00

abstract：:It is suggested that reactive oxygen species produced during ethanol intake may induce oxidative DNA damage. The present study, by the use of single cell gel electrophoresis (comet assay), investigated the potential genotoxicity of acute and long-term ethanol administration in mouse peripheral leucocytes. Urinary 8-hy...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guo L,Yang JY,Wu CF

更新日期：2008-09-01 00:00:00

abstract：:Selenium is an essential trace element with growth-modulating properties. Decades of research clearly demonstrate that selenium compounds inhibit the growth of malignant cells in diverse experimental model systems. However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remark...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wallenberg M,Misra S,Björnstedt M

更新日期：2014-05-01 00:00:00

abstract：:Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives of the present study were to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for simvastatin and to evaluate its usefulness in predicting the dose-response relationship of simvastatin...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim J,Ahn BJ,Chae HS,Han S,Doh K,Choi J,Jun YK,Lee YW,Yim DS

更新日期：2011-09-01 00:00:00

abstract：:Lornoxicam is extensively metabolized by CYP2C9, and a CYP2C9*13 is one of the principal variant alleles in East Asian populations. The aim of this study was to evaluate the effects of CYP2C9*1/*13 on the pharmacokinetic parameters of lornoxicam in healthy individuals. A single oral dose of 8 mg lornoxicam was given t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Choi CI,Kim MJ,Jang CG,Park YS,Bae JW,Lee SY

更新日期：2011-12-01 00:00:00

abstract：:In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predict...

journal_title：Basic & clinical pharmacology & toxicology

authors： Petersen TK

更新日期：2006-08-01 00:00:00

abstract：:Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and growth, although the involved molecular mechanisms have not been elucidated. In many cancer cells, high expression of thymidine phosphorylase (TP) and Excision repair cross-complementation 1 (ERCC1) is associated with poor progno...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ko JC,Huang YC,Chen HJ,Tseng SC,Chiu HC,Wo TY,Huang YJ,Weng SH,Chiou RY,Lin YW

更新日期：2013-07-01 00:00:00

abstract：:Epidemiological studies have suggested that human exposure to extremely low-frequency electromagnetic fields from the electric power and to mobile phone radiofrequency electromagnetic fields induce an increased risk of developing malignant tumours. However, no adequate laboratory data, in particular long-term carcinog...

journal_title：Basic & clinical pharmacology & toxicology

authors： Soffritti M,Giuliani L

更新日期：2019-08-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from the heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-do...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Veggel M,Van der Veen G,Jansen T,Westerman E

更新日期：2017-11-01 00:00:00

abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ogur R,Uysal B,Ogur T,Yaman H,Oztas E,Ozdemir A,Hasde M

更新日期：2007-05-01 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...

journal_title：Basic & clinical pharmacology & toxicology

authors： Damkier P,Lassen D,Christensen MMH,Madsen KG,Hellfritzsch M,Pottegård A

更新日期：2019-01-01 00:00:00

abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Möller J,Laflamme L,Söderberg Löfdal K

更新日期：2015-02-01 00:00:00

abstract：BACKGROUND:Long non-coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) is a novel vital oncogenic lncRNA that is dysregulated in various types of cancers, including glioma. According to TargetScan prediction, miR-432-5p is a target of ZFAS1. Herein, we aimed to determine whether there was a correlation between ZFAS1 a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang G,Han B,Feng T

更新日期：2019-12-01 00:00:00

abstract：:Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord. The aim of the present study was to ascertain whether this pattern of COX-2 and COX-1 expression applies also to other pain conditions induced by surgical proc...

journal_title：Basic & clinical pharmacology & toxicology

authors： Prochazkova M,Dolezal T,Sliva J,Krsiak M

更新日期：2006-08-01 00:00:00

abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

更新日期：2018-04-01 00:00:00

abstract：:Carbon monoxide (CO) poisoning is a leading cause of unintentional poisoning deaths in many countries. In ex vivo studies, CO released from carbon monoxide-releasing molecules has been shown to attenuate fibrinolysis via increased alpha-2-antiplasmin activity. Hypofibrinolysis is associated with coronary ischaemia, wh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Gawlikowski T,Gomolka E,Piekoszewski W,Jawień W,Undas A

更新日期：2013-05-01 00:00:00

abstract：:The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of Garcinia kola) and curcumin (from the rhizome, Curcuma longa L.) on the di-n-butylphthalate (DBP)-induced testicular damage in rats. Administration of DBP to rats at a dose of 2 g/kg for 9 days signific...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farombi EO,Abarikwu SO,Adedara IA,Oyeyemi MO

更新日期：2007-01-01 00:00:00