Curcumin and kolaviron ameliorate di-n-butylphthalate-induced testicular damage in rats.

abstract：:Endotoxin-induced sepsis in pigs is a recognized experimental model for the study of human septic shock. Generally, pigs are brought into general anaesthesia before sepsis is induced. It is our experience that drug dosages of propofol and fentanyl need to be reduced during endotoxin-induced sepsis, in order to prevent...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bollen PJ,Nielsen BJ,Toft P

更新日期：2007-09-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:Is it not more comfortable to spit saliva in a tube than to be pricked with a needle to draw blood to analyse your health and disease risk? Many patients, study participants and (parents of) young children undoubtedly prefer non-invasive and convenient procedures. Such procedures increase compliance rates especially f...

journal_title：Basic & clinical pharmacology & toxicology

authors： Langie SAS,Moisse M,Declerck K,Koppen G,Godderis L,Vanden Berghe W,Drury S,De Boever P

更新日期：2017-09-01 00:00:00

abstract：:The beneficial effects of kolaviron, a natural biflavonoid from the seeds of Garcinia kola, have been attributed mainly to its antioxidant and anti-inflammatory effects. This study investigated these effects on dextran sulphate sodium (DSS)-induced ulcerative colitis in rats. Sulfasalazine served as standard reference...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farombi EO,Adedara IA,Ajayi BO,Ayepola OR,Egbeme EE

更新日期：2013-07-01 00:00:00

abstract：:Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity to different tumour cell lines. α-Eudesmol showed IC₅₀ values ranging from 5.38 ± 1.10 to 10.60 ± 1.33 μg/mL for B16-F10 and K562 cell lines, β-eudesmol showed I...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bomfim DS,Ferraz RP,Carvalho NC,Soares MB,Pinheiro ML,Costa EV,Bezerra DP

更新日期：2013-11-01 00:00:00

abstract：:Despite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significan...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk S,Lund C,Clemmensen C

更新日期：2020-06-01 00:00:00

abstract：:The aim of the present study was to examine the effects of formaldehyde solution on rat left ventricular function and compare it with those in hypertrophic hearts treated with isoproterenol by pressure-volume measurements with the catheter method. After 20-30 min. of intravenous infusion of 3.7% formaldehyde solution ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Takeshita D,Nakajima-Takenaka C,Shimizu J,Hattori H,Nakashima T,Kikuta A,Matsuyoshi H,Takaki M

更新日期：2009-10-01 00:00:00

abstract：:Curcumin is the effective ingredient of turmeric, sometimes used as a painkiller in traditional medicine. It has extensive biological properties such as anti-inflammatory and antioxidant activities. SARS-CoV-2 is a betacoronavirus developing severe pneumonitis. Inflammasome is one of the most important components of i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saeedi-Boroujeni A,Mahmoudian-Sani MR,Bahadoram M,Alghasi A

更新日期：2021-01-01 00:00:00

abstract：:The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents. Here, we report that among the six characterized SF-derived quinolizidine alkaloids including sophoridine...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lin Z,Huang CF,Liu XS,Jiang J

更新日期：2011-05-01 00:00:00

abstract：:Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study with the objective to evaluate the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellfritzsch M,Pottegård A,Pedersen AJ,Burghle A,Mouaanaki F,Hallas J,Grove EL,Damkier P

更新日期：2017-04-01 00:00:00

abstract：:Young mice (2 weeks old) were given topiramate daily for 1 month, and sudomotor function was evaluated utilizing impression mould techniques to determine the number of sweat glands reactive to heat exposure and sweat output per gland on the plantar surface of mice hind-paws. Immunohistochemical quantitation of protein...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tian J,Huang Y,Deng Y,Chen J,Ma L,Chen X,Jiang W,Zhao G,Wang J

更新日期：2007-06-01 00:00:00

abstract：:Vascular networks are dynamic structures, adapting to changing conditions by structural remodelling of vessel diameters and by growth of new vessels and regression of existing vessels. The vast number of blood vessels in the circulatory system, more than 10⁹, implies that vessels' arrangement and structure are not und...

journal_title：Basic & clinical pharmacology & toxicology

authors： Secomb TW,Dewhirst MW,Pries AR

更新日期：2012-01-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) has been connected to learning, memory and mood. Changes in serum or plasma POP activity have been linked to psychiatric disorders. POP has been thought to interfere in these conditions by cleaving neuroactive peptides or via the phosphatidylinositol second messenger system. However, little...

journal_title：Basic & clinical pharmacology & toxicology

authors： Peltonen I,Männistö PT

更新日期：2011-01-01 00:00:00

abstract：:P-glycoprotein (P-gp), an important efflux transporter in intestine, regulates the bioavailability of orally taken drugs. To develop an in vitro model that preferably mimics the physiological microenvironment of human intestine, we employed the three-dimensionally (3D) cultured organoids from human normal small intest...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao J,Zeng Z,Sun J,Zhang Y,Li D,Zhang X,Liu M,Wang X

更新日期：2017-03-01 00:00:00

abstract：:Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample c...

journal_title：Basic & clinical pharmacology & toxicology

authors： Neuvonen M,Tarkiainen EK,Tornio A,Hirvensalo P,Tapaninen T,Paile-Hyvärinen M,Itkonen MK,Holmberg MT,Kärjä V,Männistö VT,Neuvonen PJ,Pihlajamäki J,Backman JT,Niemi M

更新日期：2018-03-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:To study the potential interactions of naringin (NAR), talinolol (TAL) and protein-energy undernutrition (PEU) in the absorption process of saquinavir (SQV), perfusion experiments were performed in the small intestine of rats at different SQV concentrations. The results obtained demonstrated that SQV intestinal absorp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Catalán-Latorre A,Nácher A,Merino V,Jiménez-Torres NV,Merino-Sanjuán M

更新日期：2011-10-01 00:00:00

abstract：:This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang S,Tang X,Tian J,Li C,Zhang G,Jiang W,Zhang Z

更新日期：2011-06-01 00:00:00

abstract：:Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. Although such drugs, especially ranitidine and famotidine, are still widely used, their effects on semen quality, and hence on male infertility, is still u...

journal_title：Basic & clinical pharmacology & toxicology

authors： Banihani SA

更新日期：2016-01-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:The aim is to emphasize the importance of extracardiac symptoms of digoxin intoxication in newborns. The most common intoxication symptoms in adults are of cardiac origin, but due to altered symptomatology, digoxin overdose in infants are not always discovered on symptomatic basis. In preterm infants, this is even mor...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nybo M,Damkier P

更新日期：2005-06-01 00:00:00

abstract：:The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from the heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-do...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Veggel M,Van der Veen G,Jansen T,Westerman E

更新日期：2017-11-01 00:00:00

abstract：:QF-036 is an HIV-1 maturation inhibitor in pre-clinical development, and its antiviral activity against a laboratory HIV-1 strain and two drug-resistant strains was determined in the C8166 line. QF-036 was also subjected to absorption, distribution and metabolism (ADM) assessment in vitro, and pharmacokinetic profiles...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao L,He HH,Ou-Yang T,Liu DF,Jiang CH,Yang HP,Wang P,Xie N,Yan SS

更新日期：2021-02-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors widely distributed in the central nervous system, and have been extensively investigated for their roles in embryonic development, synaptic plasticity and neuroexcitoxicity. Their functions in the peripheral nervous system and non-neural tissues ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shen L,Li L,She H,Yue S,Li C,Luo Z

更新日期：2010-09-01 00:00:00

abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

journal_title：Basic & clinical pharmacology & toxicology

authors： Iversen TZ,Andersen MH,Svane IM

更新日期：2015-01-01 00:00:00

abstract：:Polyphenols are ubiquitous substances in human diet. Their antioxidative, antiinflammatory and antiviral effects are of interest for human health, and polyphenols such as luteolin are used at high concentrations in food supplements. Luteolin is metabolized to glucuronides, but also to methylated derivatives. For examp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Michels G,Mohamed GA,Weber N,Chovolou Y,Kampkötter A,Wätjen W,Proksch P

更新日期：2006-02-01 00:00:00

abstract：:Epidemiological data have shown that methamphetamine (MA) abuse significantly increases the risk of developing pulmonary arterial hypertension (PAH). To investigate whether MA could induce PAH and its possible mechanism, rats were exposed daily to MA for 5 weeks in the absence or presence of fluoxetine. The results sh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu M,Wang Y,Wang HM,Bai Y,Zhang XH,Sun YX,Wang HL

更新日期：2013-02-01 00:00:00

abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saario SM,Laitinen JT

更新日期：2007-11-01 00:00:00

abstract：:The antithrombotic and antiplatelet activities of Korean red ginseng extract (KRGE) were examined on rat carotid artery thrombosis in vivo and platelet aggregation in vitro and ex vivo. The KRGE significantly prevented rat carotid arterial thrombosis in vivo in a dose-dependent manner. Administration of the KRGE to ra...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Yu JY,Lee JJ,You SH,Chung JH,Noh JY,Im JH,Han XH,Kim TJ,Shin KS,Wee JJ,Yun YP

更新日期：2007-03-01 00:00:00

abstract：:In recent years, several online tools have appeared capable of identifying potential plagiarism in science. While such tools may help to maintain or even increase the originality and ethical quality of the scientific literature, no apparent consensus exists among editors on the degree of plagiarism or self-plagiarism ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lykkesfeldt J

更新日期：2016-08-01 00:00:00