Fluoxetine attenuates chronic methamphetamine-induced pulmonary arterial remodelling: possible involvement of serotonin transporter and serotonin 1B receptor.

abstract：:This study investigated the antinociceptive effects of zerumbone in chemical behavioural models of nociception in mice. Zerumbone given through intraperitoneal route (i.p.) produced dose-related antinociception when assessed on acetic acid-induced abdominal writhing test in mice. In addition, the i.p. administration o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Perimal EK,Akhtar MN,Mohamad AS,Khalid MH,Ming OH,Khalid S,Tatt LM,Kamaldin MN,Zakaria ZA,Israf DA,Lajis N,Sulaiman MR

更新日期：2011-03-01 00:00:00

abstract：:The endothelium plays crucial roles in modulating vascular tone by synthesizing and releasing endothelium-derived relaxing factors (EDRFs), including vasodilator prostaglandins, nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) factors. Thus, endothelial dysfunction is the hallmark of atherosclerotic...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shimokawa H,Godo S

更新日期：2020-08-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:Endotoxin-induced sepsis in pigs is a recognized experimental model for the study of human septic shock. Generally, pigs are brought into general anaesthesia before sepsis is induced. It is our experience that drug dosages of propofol and fentanyl need to be reduced during endotoxin-induced sepsis, in order to prevent...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bollen PJ,Nielsen BJ,Toft P

更新日期：2007-09-01 00:00:00

abstract：:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto...

journal_title：Basic & clinical pharmacology & toxicology

authors： Han L,Howe JR,Pickering DS

更新日期：2016-08-01 00:00:00

abstract：:Opioids given to pregnant and parturient women are relatively freely transferred across the placenta. Spinal, epidural and intravenous fentanyl has been studied in pregnant women and neonates, but foetal safety of fentanyl dosing with transdermal patch during pregnancy and labour is not sufficiently studied. Foetal pH...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen EM,Kokki H,Heikkinen A,Ranta VP,Räsänen J,Voipio HM,Kokki M

更新日期：2017-02-01 00:00:00

abstract：:Certain chemotherapeutic agents subject cells to oxidative stress, thereby promoting adverse effects. However, the molecular machinery governing 5-fluorouracil (5-FU)-mediated myelotoxicity is obscure. The purpose of this study was to clarify whether 5-FU-induced myelotoxicity is a cause of oxidative stress. Treatment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Numazawa S,Sugihara K,Miyake S,Tomiyama H,Hida A,Hatsuno M,Yamamoto M,Yoshida T

更新日期：2011-01-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:This study investigates the oxidative damage of biomolecules in livers of mice treated with morphine intraperitoneally. The oxidative damage of DNA as measured by single cell electrophoresis and high-performance liquid chromatography equipped with electrochemical and UV detection, the protein carbonyl content was meas...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang YT,Zheng QS,Pan J,Zheng RL

更新日期：2004-08-01 00:00:00

abstract：:Extrasynaptic δ subunit-containing γ-aminobutyric acid type A receptors (δ-GABAA Rs) are emerging as targets for a number of neuropsychopharmacological drugs, including the direct GABA site agonist gaboxadol and neuroactive steroids. Among other regions, these δ-GABAA Rs are functionally expressed in the ventral tegme...

journal_title：Basic & clinical pharmacology & toxicology

authors： Siivonen MS,de Miguel E,Aaltio J,Manner AK,Vahermo M,Yli-Kauhaluoma J,Linden AM,Aitta-Aho T,Korpi ER

更新日期：2018-11-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. In patients for whom HCC could not be detected early, current treatments show poor tolerance and low efficacy. So, alternative therapies with good efficacy are urgently needed. The aim of this research was to evaluate the selective ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Seydi E,Rasekh HR,Salimi A,Mohsenifar Z,Pourahmad J

更新日期：2016-09-01 00:00:00

abstract：:Annona vepretorum Mart. (Annonaceae), popularly known as 'bruteira', has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with β-cyclodextrin in a microencapsulation. The essential oil was obtained b...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bomfim LM,Menezes LR,Rodrigues AC,Dias RB,Rocha CA,Soares MB,Neto AF,Nascimento MP,Campos AF,Silva LC,Costa EV,Bezerra DP

更新日期：2016-03-01 00:00:00

abstract：:This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Stage C,Jürgens G,Guski LS,Thomsen R,Bjerre D,Ferrero-Miliani L,Lyauk YK,Rasmussen HB,Dalhoff K,INDICES Consortium (for members of this consortium-see Supplementum).

更新日期：2017-12-01 00:00:00

abstract：:Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hubacek JA,Pelclova D,Seidl Z,Vaneckova M,Klempir J,Ruzicka E,Ridzon P,Urban P,Fenclova Z,Petrik V,Diblik P,Kuthan P,Miovsky M,Janikova B,Adamkova V,Zakharov S

更新日期：2015-02-01 00:00:00

abstract：:Aripiprazole is an antipsychotic that acts as a partial agonist at dopamine receptors. As the effects of most drugs of abuse converge to enhance dopamine-mediated neurotransmission, the present study was designed to test the hypothesis that aripiprazole would inhibit the acute effects of ethanol, a widely abused subst...

journal_title：Basic & clinical pharmacology & toxicology

authors： Viana TG,Almeida-Santos AF,Aguiar DC,Moreira FA

更新日期：2013-05-01 00:00:00

abstract：:In cardiovascular and metabolic diseases, small resistance arteries may show the presence of structural alterations. In particular, in essential hypertension, an increased media-to-lumen ratio of subcutaneous small arteries with no change in the total amount of vascular wall tissue (eutrophic remodelling) has already ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rizzoni D,De Ciuceis C,Porteri E,Semeraro F,Rosei EA

更新日期：2012-01-01 00:00:00

abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ogur R,Uysal B,Ogur T,Yaman H,Oztas E,Ozdemir A,Hasde M

更新日期：2007-05-01 00:00:00

abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...

journal_title：Basic & clinical pharmacology & toxicology

authors： Raaska K,Raitasuo V,Laitila J,Neuvonen PJ

更新日期：2004-01-01 00:00:00

abstract：:This report presents the results of two treatment cross-over investigations on 20 healthy male volunteers to assess the bioequivalence of two suppository products of diclofenac sodium. The study was carried out under US Food and Drug Administration Guidelines. The two products were voltaren (100 mg) suppository (Ciba-...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hasan M,Otoom S,Najib N,Sallam el-S

更新日期：2004-12-01 00:00:00

abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

更新日期：2018-04-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors widely distributed in the central nervous system, and have been extensively investigated for their roles in embryonic development, synaptic plasticity and neuroexcitoxicity. Their functions in the peripheral nervous system and non-neural tissues ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shen L,Li L,She H,Yue S,Li C,Luo Z

更新日期：2010-09-01 00:00:00

abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2008-05-01 00:00:00

abstract：:Although commonly associated with obesity, non-alcoholic fatty liver disease (NAFLD) is also present in the lean population representing a unique disease phenotype. Affecting 25% of the world's population, NAFLD is associated with increased mortality especially when progressed to non-alcoholic steatohepatitis (NASH). ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ipsen DH,Rolin B,Rakipovski G,Skovsted GF,Madsen A,Kolstrup S,Schou-Pedersen AM,Skat-Rørdam J,Lykkesfeldt J,Tveden-Nyborg P

更新日期：2018-12-01 00:00:00

abstract：:Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is li...

journal_title：Basic & clinical pharmacology & toxicology

authors： Király I,Pataricza J,Bajory Z,Simonsen U,Varro A,Papp JG,Pajor L,Kun A

更新日期：2013-07-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) has been connected to learning, memory and mood. Changes in serum or plasma POP activity have been linked to psychiatric disorders. POP has been thought to interfere in these conditions by cleaving neuroactive peptides or via the phosphatidylinositol second messenger system. However, little...

journal_title：Basic & clinical pharmacology & toxicology

authors： Peltonen I,Männistö PT

更新日期：2011-01-01 00:00:00

abstract：:The present in vivo study investigated the genotoxicity of four dental resin monomers: triethyleneglycoldimethacrylate (TEGDMA), hydroxyethylmethacrylate (HEMA), urethanedimethacrylate (UDMA) and bisphenol A-glycidylmethacrylate (BisGMA). The Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster w...

journal_title：Basic & clinical pharmacology & toxicology

authors： Arossi GA,Lehmann M,Dihl RR,Reguly ML,de Andrade HH

更新日期：2010-02-01 00:00:00

abstract：:δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the rec...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk-Petersen CB,Søgaard R,Madsen KL,Klein AB,Frølund B,Wellendorph P

更新日期：2017-08-01 00:00:00

abstract：:Carbon monoxide (CO) poisoning is a leading cause of unintentional poisoning deaths in many countries. In ex vivo studies, CO released from carbon monoxide-releasing molecules has been shown to attenuate fibrinolysis via increased alpha-2-antiplasmin activity. Hypofibrinolysis is associated with coronary ischaemia, wh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Gawlikowski T,Gomolka E,Piekoszewski W,Jawień W,Undas A

更新日期：2013-05-01 00:00:00

abstract：:Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Origanum majorana L., Lamiaceae, is a potent antioxidant. The effect of administration of O. majorana (volatile oil, alcoholic and aqueous extracts) on oral administration of lead acetate in the diet of ...

journal_title：Basic & clinical pharmacology & toxicology

authors： el-Ashmawy IM,el-Nahas AF,Salama OM

更新日期：2005-10-01 00:00:00