Protective effect of volatile oil, alcoholic and aqueous extracts of Origanum majorana on lead acetate toxicity in mice.

abstract：:Maximizing the likelihood of success in Phase III is the ultimate goal of the use of modelling and simulation in the drug development process. The success in Phase III depends primarily on two questions: 1) Is the drug regimen actually efficacious and safe in the targeted patient population?, and 2) Will the planned P...

journal_title：Basic & clinical pharmacology & toxicology

authors： De Ridder F

更新日期：2005-03-01 00:00:00

abstract：:Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is li...

journal_title：Basic & clinical pharmacology & toxicology

authors： Király I,Pataricza J,Bajory Z,Simonsen U,Varro A,Papp JG,Pajor L,Kun A

更新日期：2013-07-01 00:00:00

abstract：:Epidemiological data have shown that methamphetamine (MA) abuse significantly increases the risk of developing pulmonary arterial hypertension (PAH). To investigate whether MA could induce PAH and its possible mechanism, rats were exposed daily to MA for 5 weeks in the absence or presence of fluoxetine. The results sh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu M,Wang Y,Wang HM,Bai Y,Zhang XH,Sun YX,Wang HL

更新日期：2013-02-01 00:00:00

abstract：:Methionine-choline-deficient diet represents a model for the study of the pathogenesis of steatohepatitis. Male rats were divided into three groups, the first group receiving a control diet and the other two groups receiving a methionine-choline-deficient diet for 1 month (MCD1) and for 2 months (MCD2), respectively. ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jordao AA,Zanutto ME,Domenici FA,Portari GV,Cecchi AO,Zucoloto S,Vannucchi H

更新日期：2009-09-01 00:00:00

abstract：:Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives of the present study were to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for simvastatin and to evaluate its usefulness in predicting the dose-response relationship of simvastatin...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim J,Ahn BJ,Chae HS,Han S,Doh K,Choi J,Jun YK,Lee YW,Yim DS

更新日期：2011-09-01 00:00:00

abstract：:This MiniReview is focused on the nature of intercellular signalling along the endothelium that helps to co-ordinate blood flow control in vascular resistance networks. Vasodilation initiated by contracting skeletal muscle ascends from arterioles within the tissue to encompass resistance arteries upstream and thereby ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Socha MJ,Behringer EJ,Segal SS

更新日期：2012-01-01 00:00:00

abstract：:δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the rec...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk-Petersen CB,Søgaard R,Madsen KL,Klein AB,Frølund B,Wellendorph P

更新日期：2017-08-01 00:00:00

abstract：:Rapamycin is a macrocyclic lactone currently used for the treatment of cancer and for the prevention of transplant rejection. The primary pharmacological mode of action of rapamycin occurs through the inhibition (blocking) of the mammalian target of rapamycin (mTOR). By doing so, rapamycin interferes with the phosphoi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fagone P,Donia M,Mangano K,Quattrocchi C,Mammana S,Coco M,Libra M,McCubrey JA,Nicoletti F

更新日期：2013-01-01 00:00:00

abstract：:Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminif...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bjørklund G,Chirumbolo S,Dadar M,Pivina L,Lindh U,Butnariu M,Aaseth J

更新日期：2019-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading inevitably to death in respiratory failure. ALS is a model condition for neurodegenerative disorders. Exposure to different agents dispersed in the environment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Roos PM,Dencker L

更新日期：2012-08-01 00:00:00

abstract：:Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample c...

journal_title：Basic & clinical pharmacology & toxicology

authors： Neuvonen M,Tarkiainen EK,Tornio A,Hirvensalo P,Tapaninen T,Paile-Hyvärinen M,Itkonen MK,Holmberg MT,Kärjä V,Männistö VT,Neuvonen PJ,Pihlajamäki J,Backman JT,Niemi M

更新日期：2018-03-01 00:00:00

abstract：:In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3A activity in healthy volunteers from Swe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nylén H,Björkhem-Bergman L,Ekström L,Roh HK,Bertilsson L,Eliasson E,Lindh JD,Diczfalusy U

更新日期：2014-10-01 00:00:00

abstract：:Extrasynaptic δ subunit-containing γ-aminobutyric acid type A receptors (δ-GABAA Rs) are emerging as targets for a number of neuropsychopharmacological drugs, including the direct GABA site agonist gaboxadol and neuroactive steroids. Among other regions, these δ-GABAA Rs are functionally expressed in the ventral tegme...

journal_title：Basic & clinical pharmacology & toxicology

authors： Siivonen MS,de Miguel E,Aaltio J,Manner AK,Vahermo M,Yli-Kauhaluoma J,Linden AM,Aitta-Aho T,Korpi ER

更新日期：2018-11-01 00:00:00

abstract：:This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Stage C,Jürgens G,Guski LS,Thomsen R,Bjerre D,Ferrero-Miliani L,Lyauk YK,Rasmussen HB,Dalhoff K,INDICES Consortium (for members of this consortium-see Supplementum).

更新日期：2017-12-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) has been found to elicit enhanced contractile effects in some vascular disorders. The present study was designed to examine if vascular 5-HT2A receptors are up-regulated during organ culture and if the extracellular signal-regulated protein kinase 1/2 (ERK1/2) pathways are involved. Compared...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cao YX,He LC,Xu CB,Luo GG,Edvinsson L

更新日期：2005-04-01 00:00:00

abstract：:This work demonstrates how full modelling power in statistically mixed models can be used to study generalizability (reliability) coefficients of advanced data from human experimental pain studies utilizing placebo data from drug screening trials. This can be used to help optimizing outcome parameters from existing da...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pryseley A,Ledent EY,Drewes AM,Staahl C,Olesen AE,Arendt-Nielsen L

更新日期：2009-08-01 00:00:00

abstract：:Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P,Abdennebi-Najar L,Barouki R,Cranor CF,Etzel RA,Gee D,Heindel JJ,Hougaard KS,Hunt P,Nawrot TS,Prins GS,Ritz B,Soffritti M,Sunyer J,Weihe P

更新日期：2019-08-01 00:00:00

abstract：:Hypotensive effects of oral sodium nitrite have been reported as alternative sources of nitric oxide (NO) formation in animals and human beings. Reductions in NO bioavailability were observed in lead-induced hypertension. However, no previous study has examined whether a single daily dose of sodium nitrite prevents th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Gonçalves-Rizzi VH,Nascimento RA,Possomato-Vieira JS,Dias-Junior CA

更新日期：2016-03-01 00:00:00

abstract：:Concurrent administration of chloramphenicol (CAP) with multivitamin-haematinics complex (MHC) is a common practice to cushioning anticipated anaemic effect of CAP in most developing countries. This study investigated the mechanism involved in CAP-induced reproductive toxicity as well as the effects of its co-administ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Oyagbemi AA,Adedara IA,Saba AB,Farombi EO

更新日期：2010-09-01 00:00:00

abstract：:Hematide is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented inclu...

journal_title：Basic & clinical pharmacology & toxicology

authors： Woodburn KW,Wilson SD,Fong KL,Schatz PJ,Spainhour CB,Norton D

更新日期：2009-02-01 00:00:00

abstract：:Radial artery frequently develops spasm and requires vasodilator therapy during coronary artery bypass graft surgery (CABG). Levosimendan was recently shown to oppose 5-hydroxytryptamine-induced contraction of radial artery (RA) grafts. The aim of the present study was to explore whether levosimendan retains its vasod...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ambrus N,Szolnoky J,Pollesello P,Kun A,Varró A,Papp JG,Pataricza J

更新日期：2012-03-01 00:00:00

abstract：:Doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. Selected...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wattanapitayakul SK,Chularojmontri L,Herunsalee A,Charuchongkolwongse S,Niumsakul S,Bauer JA

更新日期：2005-01-01 00:00:00

abstract：:To clarify the action of a side-effect of phenylbutazone, we investigated the inactivation of alpha(1)-antiproteinase induced by phenylbutazone in the presence of horseradish peroxidase (HRP) and H(2)O(2) (HRP-H(2)O(2)). The activity of alpha(1)-antiproteinase was rapidly lost during the interaction of phenylbutazone ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Muraoka S,Miura T

更新日期：2006-09-01 00:00:00

abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...

journal_title：Basic & clinical pharmacology & toxicology

authors： Faro LR,Alfonso M,Cervantes R,Durán R

更新日期：2009-12-01 00:00:00

abstract：:The activation of Nod-like receptor protein 3 (NLRP3) has lately been implicated in stress and depression as an initiator mechanism required for the production of interleukin (IL)-1β and IL-18. Agmatine, an endogenous polyamine widely distributed in mammalian brain, is a novel neurotransmitter/neuromodulator, with ant...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sahin C,Albayrak O,Akdeniz TF,Akbulut Z,Yanikkaya Demirel G,Aricioglu F

更新日期：2016-10-01 00:00:00

abstract：:Imbalanced matrix metalloproteinase (MMP) expression, including MMP-2, has been demonstrated in pre-eclampsia. However, little is known about the effect of polymorphisms in MMP-2 gene on hypertensive disorders of pregnancy. We examined whether two functional MMP-2 polymorphisms (g.-1306C>T and g.-735C>T) are associate...

journal_title：Basic & clinical pharmacology & toxicology

authors： Palei AC,Sandrim VC,Amaral LM,Machado JS,Cavalli RC,Lacchini R,Duarte G,Tanus-Santos JE

更新日期：2012-10-01 00:00:00

abstract：:The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid (TMCA) to reverse it. Reversal of liver fibrosis was studied in male Wistar rats after one, two or three months of CCl(...

journal_title：Basic & clinical pharmacology & toxicology

authors： Muriel P,Moreno MG,Hernández Mdel C,Chávez E,Alcantar LK

更新日期：2005-05-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors widely distributed in the central nervous system, and have been extensively investigated for their roles in embryonic development, synaptic plasticity and neuroexcitoxicity. Their functions in the peripheral nervous system and non-neural tissues ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shen L,Li L,She H,Yue S,Li C,Luo Z

更新日期：2010-09-01 00:00:00

abstract：:The advent of large population-based prescription databases has enabled us to study drug use with the individual user as our unit of analysis. This review presents three non-specific analytic templates that may be applied to individual-level prescription data. The ratio of prevalence odds to incidence rate can estimat...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hallas J,Støvring H

更新日期：2006-03-01 00:00:00