Role of oxidative stress in reproductive toxicity induced by co-administration of chloramphenicol and multivitamin-haematinics complex in rats.

abstract：:Vitamin D metabolism was studied in primary human dermal fibroblasts with focus on drug-mediated gene regulation related to adverse side effects of antiretroviral drugs used in HIV therapy. The fibroblasts expressed mRNA for cytochrome P450 (CYP) enzymes catalysing bioactivating (CYP2R1, CYP27A1 and CYP27B1) and catab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Norlin M,Lundqvist J,Ellfolk M,Hellström Pigg M,Gustafsson J,Wikvall K

更新日期：2017-01-01 00:00:00

abstract：:This study investigated the impact of prolonged nicotine administration on myocardial susceptibility to ischaemia-reperfusion (I/R) injury in a rat model and determined whether nicotine affects mitochondrial reactive oxygen species (ROS) production and permeability transition in rat hearts. Sprague-Dawley rats were ad...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ramalingam A,Mohd Fauzi N,Budin SB,Zainalabidin S

更新日期：2021-02-01 00:00:00

abstract：:Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of generalized vitiligo. Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that ca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lan WJ,Wang HY,Lan W,Wang KY

更新日期：2008-07-01 00:00:00

abstract：BACKGROUND:It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate whether the effectiveness ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Møller Gundersen K,Nygaard Jensen J,Bjerrum L,Hansen MP

更新日期：2019-05-01 00:00:00

abstract：:The antithrombotic and antiplatelet activities of Korean red ginseng extract (KRGE) were examined on rat carotid artery thrombosis in vivo and platelet aggregation in vitro and ex vivo. The KRGE significantly prevented rat carotid arterial thrombosis in vivo in a dose-dependent manner. Administration of the KRGE to ra...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Yu JY,Lee JJ,You SH,Chung JH,Noh JY,Im JH,Han XH,Kim TJ,Shin KS,Wee JJ,Yun YP

更新日期：2007-03-01 00:00:00

abstract：:The activation of Nod-like receptor protein 3 (NLRP3) has lately been implicated in stress and depression as an initiator mechanism required for the production of interleukin (IL)-1β and IL-18. Agmatine, an endogenous polyamine widely distributed in mammalian brain, is a novel neurotransmitter/neuromodulator, with ant...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sahin C,Albayrak O,Akdeniz TF,Akbulut Z,Yanikkaya Demirel G,Aricioglu F

更新日期：2016-10-01 00:00:00

abstract：:This work demonstrates how full modelling power in statistically mixed models can be used to study generalizability (reliability) coefficients of advanced data from human experimental pain studies utilizing placebo data from drug screening trials. This can be used to help optimizing outcome parameters from existing da...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pryseley A,Ledent EY,Drewes AM,Staahl C,Olesen AE,Arendt-Nielsen L

更新日期：2009-08-01 00:00:00

abstract：:There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mukherjee S,Saha N

更新日期：2018-03-01 00:00:00

abstract：:The introduction of new COX-2 inhibitors with high efficacy and enhanced safety profile would be a great achievement in the development of anti-inflammatory drugs. This study was designed to screen and assess the anti-inflammatory and analgesic activities as well as some of the expected side effects of some pyrazole d...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mohy El-Din MM,Senbel AM,Bistawroos AA,El-Mallah A,Nour El-Din NA,Bekhit AA,Abd El Razik HA

更新日期：2011-04-01 00:00:00

abstract：:The use of herbal or natural medicines for the treatment of various disorders has a long and extensive history. Many of these herbal medicines are finding their way onto the world market as alternatives to prescribed drugs currently available to treat various disorders/ailments. In particular, hyperlipidaemia is a maj...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang TH,Kota BP,Razmovski V,Roufogalis BD

更新日期：2005-01-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity to different tumour cell lines. α-Eudesmol showed IC₅₀ values ranging from 5.38 ± 1.10 to 10.60 ± 1.33 μg/mL for B16-F10 and K562 cell lines, β-eudesmol showed I...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bomfim DS,Ferraz RP,Carvalho NC,Soares MB,Pinheiro ML,Costa EV,Bezerra DP

更新日期：2013-11-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00

abstract：:In the present study, we investigated the hepatoprotective effects of salvianolic acid A, a novel antioxidant, against oxidative stress and acute liver injury induced by carbon tetrachloride (CCl(4)) in rats, and the mechanisms underlying its protective effects. Administration of CCl(4) to rats caused severe hepatic d...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wu ZM,Wen T,Tan YF,Liu Y,Ren F,Wu H

更新日期：2007-02-01 00:00:00

abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saario SM,Laitinen JT

更新日期：2007-11-01 00:00:00

abstract：:The study was designed to assess blood platelet sensitivity to acetylsalicylic acid and its associations with dyslipidaemia and inflammation in coronary artery disease patients. Platelet non-responsiveness to aspirin is associated with an increased risk of serious cardiovascular events. Several environmental and hered...

journal_title：Basic & clinical pharmacology & toxicology

authors： Markuszewski L,Rosiak M,Golanski J,Rysz J,Spychalska M,Watala C

更新日期：2006-05-01 00:00:00

abstract：:Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fábián K,Puskás R,Kakuk T,Prés L,Fejes D,Szegedi Z,Rojkó L,Szállási Z,Döme B,Pipek O,Moldvay J

更新日期：2018-01-01 00:00:00

abstract：:Three diterpenoid quinones (royleanone- SAR 3, horminone- SAR 26, and acetyl horminone- SAR 43) isolated from the roots of Salvia officinalis L. were tested for their cytotoxic and DNA-damaging activity in human colon carcinoma cells Caco-2 and human hepatoma cells HepG2 cultured in vitro. Cytotoxicity was measured by...

journal_title：Basic & clinical pharmacology & toxicology

authors： Slamenová D,Masterová I,Lábaj J,Horváthová E,Kubala P,Jakubíková J,Wsólová L

更新日期：2004-06-01 00:00:00

abstract：:This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang S,Tang X,Tian J,Li C,Zhang G,Jiang W,Zhang Z

更新日期：2011-06-01 00:00:00

abstract：:Naringin, an active flavonoid isolated from citrus fruit extracts, exhibits biological and pharmacological properties, such as antioxidant activity and antidiabetic effect. Mitogen-activated protein kinase (MAPK) signalling pathway has been shown to participate in hyperglycaemia-induced injury. The present study teste...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen J,Guo R,Yan H,Tian L,You Q,Li S,Huang R,Wu K

更新日期：2014-04-01 00:00:00

abstract：:Effect of carbon tetrachloride (CCl(4)) pretreatment on the biotransformation and elimination of acetaminophen were examined in male mice. A 24 hr initial dose of CCl(4) (0.05 ml/kg, intraperitioneally) reduced the induction of hepatotoxicity resulting from acetaminophen treatment (350 mg/kg, intraperitoneally) as det...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yim HK,Jung YS,Kim SY,Kim YC

更新日期：2006-02-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:Since the introduction of antivenom administration over a century ago to treat venomous snake bite, it has been the most effective therapy for saving life and limb. However, this treatment is not always effective and not without potential life-threatening side effects. We tested a new paradigm to abrogate the plasmati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nielsen VG,Losada PA

更新日期：2017-02-01 00:00:00

abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...

journal_title：Basic & clinical pharmacology & toxicology

authors： Faro LR,Alfonso M,Cervantes R,Durán R

更新日期：2009-12-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading inevitably to death in respiratory failure. ALS is a model condition for neurodegenerative disorders. Exposure to different agents dispersed in the environment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Roos PM,Dencker L

更新日期：2012-08-01 00:00:00

abstract：:In cardiovascular and metabolic diseases, small resistance arteries may show the presence of structural alterations. In particular, in essential hypertension, an increased media-to-lumen ratio of subcutaneous small arteries with no change in the total amount of vascular wall tissue (eutrophic remodelling) has already ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rizzoni D,De Ciuceis C,Porteri E,Semeraro F,Rosei EA

更新日期：2012-01-01 00:00:00

abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Sepsova V,Tumova M,Horova A,Musilek K

更新日期：2015-04-01 00:00:00

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:Osteoarthritis (OA) and the non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve OA-associated pain have been linked independently to increased cardiovascular risk. We examined the risk of cardiovascular events associated with NSAID use in patients with OA. We employed linked nationwide administrative regist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Barcella CA,Lamberts M,McGettigan P,Fosbøl EL,Lindhardsen J,Torp-Pedersen C,Gislason GH,Olsen AS

更新日期：2019-05-01 00:00:00

abstract：:Carbon monoxide (CO) poisoning is a leading cause of unintentional poisoning deaths in many countries. In ex vivo studies, CO released from carbon monoxide-releasing molecules has been shown to attenuate fibrinolysis via increased alpha-2-antiplasmin activity. Hypofibrinolysis is associated with coronary ischaemia, wh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Gawlikowski T,Gomolka E,Piekoszewski W,Jawień W,Undas A

更新日期：2013-05-01 00:00:00