Structural alterations in small resistance arteries in obesity.

abstract：:Upper gastrointestinal bleeding is a feared complication of using non-steroidal anti-inflammatory drugs (NSAIDs) or aspirin. Studies predicting the incidence rate for individuals with a given set of characteristics are lacking. The aim of this study was to develop a risk model to predict the incidence rate of upper ga...

journal_title：Basic & clinical pharmacology & toxicology

authors： Petersen J,Møller Hansen J,de Muckadell OBS,Dall M,Hallas J

更新日期：2020-05-01 00:00:00

abstract：:Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice. The new benzofuranone 4 ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Padaratz P,Fracasso M,de Campos-Buzzi F,Corrêa R,Niero R,Delle Monache F,Cechinel-Filho V

更新日期：2009-10-01 00:00:00

abstract：:There is an obvious urgent need to find effective and safe therapies to prevent both recurrence and progression of bladder cancer. In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-ka...

journal_title：Basic & clinical pharmacology & toxicology

authors： Li J,Cheng Y,Qu W,Sun Y,Wang Z,Wang H,Tian B

更新日期：2011-02-01 00:00:00

abstract：:We evaluated the effects of conjugated enzyme-nerve agent product resulting from the inhibition of bioscavenger human serum butyrylcholinesterase (Hu BChE) by nerve agents soman or VX. Rats were trained on a multiple Fixed-Ratio 32, Extinction 30 sec. (FR32, Ext30) schedule of food reinforcement and then injected (i.m...

journal_title：Basic & clinical pharmacology & toxicology

authors： Genovese RF,Sun W,Johnson CC,Ditargiani RC,Doctor BP,Saxena A

更新日期：2010-05-01 00:00:00

abstract：:Previous studies suggest that flavonol icariin protects against neuron injury after oxygen and glucose deprivation by increasing SIRT1. This study demonstrates that icariin can inhibit H(2) O(2) -induced neurotoxicity. The neuroprotection of icariin enhances the antioxidant capacity through both a direct scavenging ef...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang L,Huang S,Chen Y,Wang Z,Li E,Xu Y

更新日期：2010-11-01 00:00:00

abstract：:Current treatment of pulmonary arterial hypertension (PAH) targets three signalling pathways: the nitric oxide (NO) pathway, the endothelin pathway and the prostacyclin pathway. Riociguat is a soluble guanylate cyclase stimulator, acting via the NO pathway in a new way: unlike other common drugs targeting this pathway...

journal_title：Basic & clinical pharmacology & toxicology

authors： Toxvig AK,Wehland M,Grimm D,Infanger M,Krüger M

更新日期：2019-09-01 00:00:00

abstract：:Hypotensive effects of oral sodium nitrite have been reported as alternative sources of nitric oxide (NO) formation in animals and human beings. Reductions in NO bioavailability were observed in lead-induced hypertension. However, no previous study has examined whether a single daily dose of sodium nitrite prevents th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Gonçalves-Rizzi VH,Nascimento RA,Possomato-Vieira JS,Dias-Junior CA

更新日期：2016-03-01 00:00:00

abstract：:The last eight survivors of 80 workers accidentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during production of herbicides based on trichlorophenoxyacetic acid in 1965-1967 in a chemical factory were followed. All were men, mean age 72.4 ± 1.3 years. Their current median TCDD blood level was 112 (46-390...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pelclova D,Urban P,Fenclova Z,Vlckova S,Ridzon P,Kupka K,Meckova Z,Bezdicek O,Navratil T,Rosmus J,Zakharov S

更新日期：2018-02-01 00:00:00

abstract：:Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminif...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bjørklund G,Chirumbolo S,Dadar M,Pivina L,Lindh U,Butnariu M,Aaseth J

更新日期：2019-10-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3A activity in healthy volunteers from Swe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nylén H,Björkhem-Bergman L,Ekström L,Roh HK,Bertilsson L,Eliasson E,Lindh JD,Diczfalusy U

更新日期：2014-10-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:Ponesimod, a selective S1P1 receptor modulator, is a potential therapeutic agent for autoimmune disorders. The impact of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of ponesimod and its inactive metabolites, ACT-204426 and ACT-338375, was evaluated. Two separate single-centre, open-lab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guérard N,Zwingelstein C,Hoch M,Dingemanse J

更新日期：2016-05-01 00:00:00

abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2008-05-01 00:00:00

abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...

journal_title：Basic & clinical pharmacology & toxicology

authors： Faro LR,Alfonso M,Cervantes R,Durán R

更新日期：2009-12-01 00:00:00

abstract：:The development of medium to high-throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption an...

journal_title：Basic & clinical pharmacology & toxicology

authors： van de Waterbeemd H

更新日期：2005-03-01 00:00:00

abstract：:The dry root of Sophora flavescens Ait. (SF) has long been used in a variety of Chinese herbal formulations to treat patients with cancer. Alkaloids are commonly known to present in SF as main active constituents. Here, we report that among the six characterized SF-derived quinolizidine alkaloids including sophoridine...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lin Z,Huang CF,Liu XS,Jiang J

更新日期：2011-05-01 00:00:00

abstract：:Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity to different tumour cell lines. α-Eudesmol showed IC₅₀ values ranging from 5.38 ± 1.10 to 10.60 ± 1.33 μg/mL for B16-F10 and K562 cell lines, β-eudesmol showed I...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bomfim DS,Ferraz RP,Carvalho NC,Soares MB,Pinheiro ML,Costa EV,Bezerra DP

更新日期：2013-11-01 00:00:00

abstract：:The post-injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60-year-old Caucasian, schizophrenic, non-smoker and underweight [body mass index (BMI), 18.2 kg/m(2) ] women after the fourth intramuscular injection of 405 mg olanzapine pamoate. Clinical symptoms of PDSS were similar to those of acute...

journal_title：Basic & clinical pharmacology & toxicology

authors： Łukasik-Głębocka M,Sommerfeld K,Teżyk A,Panieński P,Żaba C,Zielińska-Psuja B

更新日期：2015-09-01 00:00:00

abstract：:Many compounds display anticholinergic effects which might give rise to cognitive impairment and even delirium. These side effects are caused by their ability to bind to muscarinic receptors in our brain. Especially with combination of compounds, these serious effects are seen. This phenomenon, known as anticholinergi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vrolijk MF,Opperhuizen A,Jansen EH,Bast A,Haenen GR

更新日期：2015-12-01 00:00:00

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00

abstract：:Inadequate antidote stocking is a global problem in hospitals. Insufficient supplies and delays in the administration of antidotes could lead to death and additional potentially negative clinical consequences. Our objective was to determine the availability of antidotes in hospitals listed on the Saudi Ministry of Hea...

journal_title：Basic & clinical pharmacology & toxicology

authors： AlTamimi A,Malhis NK,Khojah NM,Manea SA,AlTamimi A,AlShammary SA

更新日期：2018-02-01 00:00:00

abstract：:The cannabinoid 1 receptor antagonist AM 251 is known to block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. We examined the ability of AM 251 to inhibit sodium channel-dependent functions and the ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liao C,Zheng J,David LS,Nicholson RA

更新日期：2004-02-01 00:00:00

abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ogur R,Uysal B,Ogur T,Yaman H,Oztas E,Ozdemir A,Hasde M

更新日期：2007-05-01 00:00:00

abstract：:Three diterpenoid quinones (royleanone- SAR 3, horminone- SAR 26, and acetyl horminone- SAR 43) isolated from the roots of Salvia officinalis L. were tested for their cytotoxic and DNA-damaging activity in human colon carcinoma cells Caco-2 and human hepatoma cells HepG2 cultured in vitro. Cytotoxicity was measured by...

journal_title：Basic & clinical pharmacology & toxicology

authors： Slamenová D,Masterová I,Lábaj J,Horváthová E,Kubala P,Jakubíková J,Wsólová L

更新日期：2004-06-01 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...

journal_title：Basic & clinical pharmacology & toxicology

authors： Damkier P,Lassen D,Christensen MMH,Madsen KG,Hellfritzsch M,Pottegård A

更新日期：2019-01-01 00:00:00

abstract：BACKGROUND:Long non-coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) is a novel vital oncogenic lncRNA that is dysregulated in various types of cancers, including glioma. According to TargetScan prediction, miR-432-5p is a target of ZFAS1. Herein, we aimed to determine whether there was a correlation between ZFAS1 a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang G,Han B,Feng T

更新日期：2019-12-01 00:00:00

abstract：:Class F receptors, including the ten Frizzleds (FZD1-10 ) and SMO, mediate the effects of WNTs and hedgehog proteins and belong to the superfamily of G protein-coupled receptors (GPCRs). While the recent, high-resolution insight into mechanisms of GPCR activation provides a better understanding of receptor activation ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Schulte G,Kozielewicz P

更新日期：2020-06-01 00:00:00

abstract：:Microdialysis is a valuable tool to measure tissue responses. We hypothesized that skeletal muscle metabolism can be modulated by microdialysis applied drugs which alter cytosolic calcium concentration. With approval of the local animal care committee, the hind limbs of sacrificed male Sprague Dawley rats were perfuse...

journal_title：Basic & clinical pharmacology & toxicology

authors： Schuster F,Tas P,Müller R,Roewer N,Anetseder M

更新日期：2006-04-01 00:00:00

abstract：:The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mogensen S,Sverrisdóttir E,Sveinsdóttir K,Treldal C,Jensen K,Jensen AB,Kristensen CA,Jacobsen J,Kreilgaard M,Petersen J,Andersen O

更新日期：2017-01-01 00:00:00