A focus on riociguat in the treatment of pulmonary arterial hypertension.

abstract：:Ponesimod, a selective S1P1 receptor modulator, is a potential therapeutic agent for autoimmune disorders. The impact of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of ponesimod and its inactive metabolites, ACT-204426 and ACT-338375, was evaluated. Two separate single-centre, open-lab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guérard N,Zwingelstein C,Hoch M,Dingemanse J

更新日期：2016-05-01 00:00:00

abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Möller J,Laflamme L,Söderberg Löfdal K

更新日期：2015-02-01 00:00:00

abstract：:This study was undertaken in order to investigate a) the short- and long-term in vivo effects of cadmium (Cd) on brain acetylcholinesterase (AChE), (Na+, K+)-ATPase activities in adult rats, b) the concentration-dependent in vitro and in vivo (acute experiment) effects of Cd on the activity of those enzymes, c) the in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Carageorgiou H,Tzotzes V,Pantos C,Mourouzis C,Zarros A,Tsakiris S

更新日期：2004-03-01 00:00:00

abstract：:Gastric carcinoma (GC) is a pernicious neoplasm with high morbidity and mortality. Sinomenine (SIN) has long been exploited to heal rheumatoid arthritis. Recently, SIN has been discovered to exert the antitumour functions in diverse cancers. However, the impacts of SIN on GC remain indistinct. We attempted to expose t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yuan H,Zhang J,Li F,Li W,Wang H

更新日期：2019-11-01 00:00:00

abstract：:Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kuca K,Cabal J,Jung YS,Musilek K,Soukup O,Jun D,Pohanka M,Musilova L,Karasová J,Novotný L,Hrabinova M

更新日期：2009-09-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kanno S,Uwai K,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Takeshita M,Ohtake T,Kimura K,Ishikawa M

更新日期：2006-01-01 00:00:00

abstract：:Endotoxin-induced sepsis in pigs is a recognized experimental model for the study of human septic shock. Generally, pigs are brought into general anaesthesia before sepsis is induced. It is our experience that drug dosages of propofol and fentanyl need to be reduced during endotoxin-induced sepsis, in order to prevent...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bollen PJ,Nielsen BJ,Toft P

更新日期：2007-09-01 00:00:00

abstract：:Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P,Abdennebi-Najar L,Barouki R,Cranor CF,Etzel RA,Gee D,Heindel JJ,Hougaard KS,Hunt P,Nawrot TS,Prins GS,Ritz B,Soffritti M,Sunyer J,Weihe P

更新日期：2019-08-01 00:00:00

abstract：:In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predict...

journal_title：Basic & clinical pharmacology & toxicology

authors： Petersen TK

更新日期：2006-08-01 00:00:00

abstract：:Epidemiological and animal studies show that small changes in the developmental environment can induce phenotypic changes affecting an individual's responses to their later environment. These may alter the risk of chronic disease such as metabolic syndrome or cardiovascular disease. Recent research shows that animals ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanson MA,Gluckman PD

更新日期：2008-02-01 00:00:00

abstract：:Although atracurium is a widely used neuromuscular blocker, we still lack knowledge regarding some of its cellular mechanisms of action. Thus, similar to other clinically used blockers atracurium induces, both in vivo and in vitro, fade of the tetanic contraction. However, the cellular mechanisms underlying this tetan...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nascimento DC,Serra CS,Oliveira AC

更新日期：2004-07-01 00:00:00

abstract：:In previous studies we have reported that NQ301, a synthetic 1,4-naphthoquinone derivative, displays a potent antithrombotic activity, and that this might be due to antiplatelet effect, which was mediated by the inhibition of cytosolic Ca(2+) mobilization in activated platelets. In the present study, the effect of NQ3...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Cho MR,Lee KS,Lee JJ,Lim Y,Han XH,Oh KW,Hong JT,Yoo HS,Yun YP

更新日期：2005-09-01 00:00:00

abstract：:Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice. The new benzofuranone 4 ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Padaratz P,Fracasso M,de Campos-Buzzi F,Corrêa R,Niero R,Delle Monache F,Cechinel-Filho V

更新日期：2009-10-01 00:00:00

abstract：:The decapeptide degarelix is a novel competitive gonadotropin-releasing hormone receptor antagonist that has been approved for the treatment of advanced prostate cancer by the FDA and the EU authorities. In this study, the interaction of degarelix with human cytochrome P450 (CYP450) enzymes was investigated in vitro. ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sonesson A,Rasmussen BB

更新日期：2011-09-01 00:00:00

abstract：:Certain chemotherapeutic agents subject cells to oxidative stress, thereby promoting adverse effects. However, the molecular machinery governing 5-fluorouracil (5-FU)-mediated myelotoxicity is obscure. The purpose of this study was to clarify whether 5-FU-induced myelotoxicity is a cause of oxidative stress. Treatment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Numazawa S,Sugihara K,Miyake S,Tomiyama H,Hida A,Hatsuno M,Yamamoto M,Yoshida T

更新日期：2011-01-01 00:00:00

abstract：:Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. H...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim KH,Kum YS,Park YY,Park JH,Kim SJ,Lee WR,Lee KG,Han SM,Park KK

更新日期：2010-07-01 00:00:00

abstract：:In cardiovascular and metabolic diseases, small resistance arteries may show the presence of structural alterations. In particular, in essential hypertension, an increased media-to-lumen ratio of subcutaneous small arteries with no change in the total amount of vascular wall tissue (eutrophic remodelling) has already ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rizzoni D,De Ciuceis C,Porteri E,Semeraro F,Rosei EA

更新日期：2012-01-01 00:00:00

abstract：:Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Graversen C,Malver LP,Kurita GP,Staahl C,Christrup LL,Sjøgren P,Drewes AM

更新日期：2015-05-01 00:00:00

abstract：:This study investigates the oxidative damage of biomolecules in livers of mice treated with morphine intraperitoneally. The oxidative damage of DNA as measured by single cell electrophoresis and high-performance liquid chromatography equipped with electrochemical and UV detection, the protein carbonyl content was meas...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang YT,Zheng QS,Pan J,Zheng RL

更新日期：2004-08-01 00:00:00

abstract：:Vanishing bile duct syndrome is a severe cholestatic disease associated with toxic effects of medications. Stevens-Johnson syndrome is a hypersensitivity disorder that may also be caused by medications. We present a case of a 62-year-old male patient who developed vanishing bile duct syndrome a month after Stevens-Joh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Juricic D,Hrstic I,Radic D,Skegro M,Coric M,Vucelic B,Francetic I

更新日期：2010-01-01 00:00:00

abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...

journal_title：Basic & clinical pharmacology & toxicology

authors： Almeida IF,Fernandes E,Lima JL,Costa PC,Bahia MF

更新日期：2009-10-01 00:00:00

abstract：:Is it not more comfortable to spit saliva in a tube than to be pricked with a needle to draw blood to analyse your health and disease risk? Many patients, study participants and (parents of) young children undoubtedly prefer non-invasive and convenient procedures. Such procedures increase compliance rates especially f...

journal_title：Basic & clinical pharmacology & toxicology

authors： Langie SAS,Moisse M,Declerck K,Koppen G,Godderis L,Vanden Berghe W,Drury S,De Boever P

更新日期：2017-09-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00

abstract：:Hematide is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented inclu...

journal_title：Basic & clinical pharmacology & toxicology

authors： Woodburn KW,Wilson SD,Fong KL,Schatz PJ,Spainhour CB,Norton D

更新日期：2009-02-01 00:00:00

abstract：:Although commonly associated with obesity, non-alcoholic fatty liver disease (NAFLD) is also present in the lean population representing a unique disease phenotype. Affecting 25% of the world's population, NAFLD is associated with increased mortality especially when progressed to non-alcoholic steatohepatitis (NASH). ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ipsen DH,Rolin B,Rakipovski G,Skovsted GF,Madsen A,Kolstrup S,Schou-Pedersen AM,Skat-Rørdam J,Lykkesfeldt J,Tveden-Nyborg P

更新日期：2018-12-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:The potent neurotoxin saxitoxin (STX) belongs to a group of structurally related analogues produced by both marine and freshwater phytoplankton. The toxins act by blocking voltage-gated sodium channels stopping the inflow of sodium ions and the generation of action potentials. Exposure from marine sources occurs as a ...

journal_title：Basic & clinical pharmacology & toxicology

authors： O'Neill K,Musgrave IF,Humpage A

更新日期：2017-04-01 00:00:00

abstract：:The post-injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60-year-old Caucasian, schizophrenic, non-smoker and underweight [body mass index (BMI), 18.2 kg/m(2) ] women after the fourth intramuscular injection of 405 mg olanzapine pamoate. Clinical symptoms of PDSS were similar to those of acute...

journal_title：Basic & clinical pharmacology & toxicology

authors： Łukasik-Głębocka M,Sommerfeld K,Teżyk A,Panieński P,Żaba C,Zielińska-Psuja B

更新日期：2015-09-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00