In vivo pharmacological disease models for psoriasis and atopic dermatitis in drug discovery.

abstract：:Ponesimod, a selective S1P1 receptor modulator, is a potential therapeutic agent for autoimmune disorders. The impact of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of ponesimod and its inactive metabolites, ACT-204426 and ACT-338375, was evaluated. Two separate single-centre, open-lab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guérard N,Zwingelstein C,Hoch M,Dingemanse J

更新日期：2016-05-01 00:00:00

abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

更新日期：2018-04-01 00:00:00

abstract：:Snake venom components, acting in concert in the prey, cause their immobilization and initiate digestion. To achieve this, several hydrolytic enzymes of snake venom have evolved to interfere in various physiological processes, which are well defined. However, hydrolytic enzymes such as phosphatases (acid and alkaline ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dhananjaya BL,D'Souza CJ

更新日期：2011-02-01 00:00:00

abstract：:Retinal arachidonic acid (ARA) levels in form-deprived eyes decline in guinea pigs. As prostaglandin F2α (PGF2α) is an ARA metabolite and endogenous agonist of prostaglandin F receptor (FP), we have been suggested that down-regulation of PGF2α-FP receptor signalling pathway contributes to myopia onset. To test this hy...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang J,Pan M,Reinach PS,Chen R,Yu L,Zhou F,Zhang S,Qu J,Zhou X

更新日期：2018-09-01 00:00:00

abstract：:Aripiprazole is an antipsychotic that acts as a partial agonist at dopamine receptors. As the effects of most drugs of abuse converge to enhance dopamine-mediated neurotransmission, the present study was designed to test the hypothesis that aripiprazole would inhibit the acute effects of ethanol, a widely abused subst...

journal_title：Basic & clinical pharmacology & toxicology

authors： Viana TG,Almeida-Santos AF,Aguiar DC,Moreira FA

更新日期：2013-05-01 00:00:00

abstract：:Certain chemotherapeutic agents subject cells to oxidative stress, thereby promoting adverse effects. However, the molecular machinery governing 5-fluorouracil (5-FU)-mediated myelotoxicity is obscure. The purpose of this study was to clarify whether 5-FU-induced myelotoxicity is a cause of oxidative stress. Treatment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Numazawa S,Sugihara K,Miyake S,Tomiyama H,Hida A,Hatsuno M,Yamamoto M,Yoshida T

更新日期：2011-01-01 00:00:00

abstract：:While the physiological function and mechanisms of agonist-dependent G protein-coupled receptor (GPCR) internalization have been extensively studied, the functional characterization of constitutive internalization of these critically important receptors has received less attention. Here we relate the constitutive inte...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hendrik Schmidt J,Perslev M,Bukowski L,Stoklund M,Herborg F,Herlo R,Lindegaard Madsen K

更新日期：2020-06-01 00:00:00

abstract：:The introduction of new COX-2 inhibitors with high efficacy and enhanced safety profile would be a great achievement in the development of anti-inflammatory drugs. This study was designed to screen and assess the anti-inflammatory and analgesic activities as well as some of the expected side effects of some pyrazole d...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mohy El-Din MM,Senbel AM,Bistawroos AA,El-Mallah A,Nour El-Din NA,Bekhit AA,Abd El Razik HA

更新日期：2011-04-01 00:00:00

abstract：:One of the most common risks after a heart transplant is bleeding. In this study, the effect of desmopressin administration on the amount of bleeding and transfusion requirements after heart transplant surgery was investigated. In a double-blind clinical trial, 48 patients who were candidates for heart transplant surg...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jahangirifard A,Razavi MR,Ahmadi ZH,Forozeshfard M

更新日期：2017-09-01 00:00:00

abstract：:Mercaptopurine is a drug commonly used in the treatment of different types of cancer, especially acute lymphoblastic leukaemia, and autoimmune diseases such as ulcerative colitis or Crohn's disease and in patients receiving organ transplants. It is metabolized by three cytosolic enzymes. One of them, thiopurine S-meth...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saiz-Rodríguez M,Ochoa D,Belmonte C,Román M,Martínez-Ingelmo C,Ortega-Ruíz L,Sarmiento-Iglesias C,Herrador C,Abad-Santos F

更新日期：2019-04-01 00:00:00

abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2007-11-01 00:00:00

abstract：:One major prerequisite for an orally administered drug is the ability to cross the intestinal epithelia from intestinal lumen into the blood circulation. Therefore, the absorption potential of molecules is studied early on during the drug development process. Permeation experiments using cultured cell monolayers are o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen AT,Korjamo T,Mönkkönen J

更新日期：2010-03-01 00:00:00

abstract：:Pain involves responses in which both peripheral and central mechanisms contribute to the generation of pain. Pre-clinical laboratory data have supported that a topical formulation of combined diclofenac and methadone (Diclometh) may alleviate local pain, and potentially, the side effect profile should be low. We hypo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Larsen IM,Drewes AM,Olesen AE

更新日期：2018-08-01 00:00:00

abstract：:Megestrol acetate, an appetite stimulant with low bioavailability, shows increased bioavailability when taken together with food. However, the pharmacokinetic characteristics of megestrol acetate and its relation with food are not well understood. This study aimed to investigate the food effect on the pharmacokinetics...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guk J,Son H,Chae DW,Park K

更新日期：2017-03-01 00:00:00

abstract：:Doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. Selected...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wattanapitayakul SK,Chularojmontri L,Herunsalee A,Charuchongkolwongse S,Niumsakul S,Bauer JA

更新日期：2005-01-01 00:00:00

abstract：:This MiniReview is focused on the nature of intercellular signalling along the endothelium that helps to co-ordinate blood flow control in vascular resistance networks. Vasodilation initiated by contracting skeletal muscle ascends from arterioles within the tissue to encompass resistance arteries upstream and thereby ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Socha MJ,Behringer EJ,Segal SS

更新日期：2012-01-01 00:00:00

abstract：:Cigarette smoking is the principal cause of chronic obstructive pulmonary disease (COPD), especially emphysema, which is characterized by alveolar wall destruction and airspace enlargement. Apoptosis of lung structural cells is involved in the pathogenesis of COPD. Xanthine derivatives (aminophylline or theophylline) ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim YJ,Kim JY,Yoon JY,Kyung SY,Lee SP,Jeong SH,Moon C,Park JW

更新日期：2011-07-01 00:00:00

abstract：BACKGROUND:There are inadequate data on prescribed drug utilization in Sub-Saharan Africa (SSA). Drug utilization research (DUR) in this region is hampered by lack of access to databases that capture prescribed drug utilization such as health insurance claims, electronic medical records and disease registries. The prim...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ankrah D,Hallas J,Odei J,Asenso-Boadi F,Dsane-Selby L,Donneyong M

更新日期：2019-01-01 00:00:00

abstract：:Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives of the present study were to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for simvastatin and to evaluate its usefulness in predicting the dose-response relationship of simvastatin...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim J,Ahn BJ,Chae HS,Han S,Doh K,Choi J,Jun YK,Lee YW,Yim DS

更新日期：2011-09-01 00:00:00

abstract：:Omeprazole is one of the most widely used proton pump inhibitors for the treatment of gastric acid-related disorders. The major metabolic pathway of omeprazole is 5-hydroxylation, which is catalysed by CYP2C19. In this study, the effect of CYP2C19*18 and CYP2C19*19 alleles on omeprazole 5-hydroxylation was studied usi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanioka N,Tsuneto Y,Saito Y,Maekawa K,Sawada J,Narimatsu S

更新日期：2008-04-01 00:00:00

abstract：:The present in vivo study investigated the genotoxicity of four dental resin monomers: triethyleneglycoldimethacrylate (TEGDMA), hydroxyethylmethacrylate (HEMA), urethanedimethacrylate (UDMA) and bisphenol A-glycidylmethacrylate (BisGMA). The Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster w...

journal_title：Basic & clinical pharmacology & toxicology

authors： Arossi GA,Lehmann M,Dihl RR,Reguly ML,de Andrade HH

更新日期：2010-02-01 00:00:00

abstract：:To study the influence of single or repeated low-level sarin inhalation exposure on immune functions, inbred BALB/c mice were exposed to low clinically asymptomatic concentrations of sarin for 60 min. in the inhalation chamber. The evaluation of immune functions was carried out using phenotyping of CD3 (T-lymphocytes)...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Krocová Z,Sevelová L,Sheshko V,Kasalová I,Neubauerová V

更新日期：2004-03-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. Insertion/deletion (I/D) polymorphism of the gene for ACE was investigated in relation to cardiovascular, cerebrovascular, neurodegenerative and inflammatory diseases. The purpose of the present...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nacak M,Erbagci Z,Buyukafsar K,Yurtsever AS,Tiftik RN

更新日期：2007-08-01 00:00:00

abstract：:Many compounds display anticholinergic effects which might give rise to cognitive impairment and even delirium. These side effects are caused by their ability to bind to muscarinic receptors in our brain. Especially with combination of compounds, these serious effects are seen. This phenomenon, known as anticholinergi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vrolijk MF,Opperhuizen A,Jansen EH,Bast A,Haenen GR

更新日期：2015-12-01 00:00:00

abstract：:Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant num...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lucafò M,Di Silvestre A,Romano M,Avian A,Antonelli R,Martelossi S,Naviglio S,Tommasini A,Stocco G,Ventura A,Decorti G,De Iudicibus S

更新日期：2018-01-01 00:00:00

abstract：:Interest in proteomics as a tool for drug development and a myriad of other applications continues to expand at a rapid rate. Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Elrick MM,Walgren JL,Mitchell MD,Thompson DC

更新日期：2006-05-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors widely distributed in the central nervous system, and have been extensively investigated for their roles in embryonic development, synaptic plasticity and neuroexcitoxicity. Their functions in the peripheral nervous system and non-neural tissues ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shen L,Li L,She H,Yue S,Li C,Luo Z

更新日期：2010-09-01 00:00:00

abstract：:The Danish Poison Information Centre (DPIC) regularly receives inquiries about nursing home residents who have been exposed to a medication error. The aim of this prospective cohort study was to describe and discuss the types and consequences of these errors. Data were collected from 1 March 2018 to 31 March 2019. Reg...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vinther S,Bøgevig S,Eriksen KR,Hansen NB,Petersen TS,Dalhoff KP,Christensen MB

更新日期：2020-11-04 00:00:00

abstract：:Hematide is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented inclu...

journal_title：Basic & clinical pharmacology & toxicology

authors： Woodburn KW,Wilson SD,Fong KL,Schatz PJ,Spainhour CB,Norton D

更新日期：2009-02-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00