当前位置： SCI文献检索 > BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY期刊下所有文献 > Inhibition of pulmonary surfactants synthesis during N-methyl-D-aspartate-induced lung injury.

Inhibition of pulmonary surfactants synthesis during N-methyl-D-aspartate-induced lung injury.

Abstract：

:N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors widely distributed in the central nervous system, and have been extensively investigated for their roles in embryonic development, synaptic plasticity and neuroexcitoxicity. Their functions in the peripheral nervous system and non-neural tissues have caught much attention recently. Over-activation of NMDA receptors induces excitotoxic lung injury. But the endogenous cell types in the lungs that express NMDA receptors remains elusive and the molecular mechanism underlies NMDA-induced lung injury has not been fully characterized. In this work, we reported that functional NMDA receptors were expressed in alveolar type II cells in the lungs. Over-activation of these receptors led to down-regulation of pulmonary surfactants synthesis. We further demonstrated that decreased cellular choline-phosphate cytidylyltransferase alpha expression induced by NMDA treatment accounted for the decreased pulmonary surfactants synthesis. Our results provided important clues for treatment of glutamate lung injury by modulating pulmonary surfactants system.

journal_name

Basic Clin Pharmacol Toxicol

journal_title

Basic & clinical pharmacology & toxicology

authors

Shen L,Li L,She H,Yue S,Li C,Luo Z

doi

10.1111/j.1742-7843.2010.00572.x

subject

Has Abstract

pub_date

2010-09-01 00:00:00

pages

751-7

issue

3

eissn

1742-7835

issn

1742-7843

pii

PTO572

journal_volume

107

pub_type

杂志文章

相关文献

BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY文献大全
  • The in vitro inhibitory potential of trade herbal products on human CYP2D6-mediated metabolism and the influence of ethanol.

    abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2007.00121.x

    authors： Hellum BH,Nilsen OG

    更新日期：2007-11-01 00:00:00

  • The targeting of indoleamine 2,3 dioxygenase -mediated immune escape in cancer.

    abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章,评审

    doi：10.1111/bcpt.12320

    authors： Iversen TZ,Andersen MH,Svane IM

    更新日期：2015-01-01 00:00:00

  • Methadone is a non-competitive antagonist at the α4β2 and α3* nicotinic acetylcholine receptors and an agonist at the α7 nicotinic acetylcholine receptor.

    abstract：:Nicotine-methadone interactions have been studied in human beings and in various experimental settings regarding addiction, reward and pain. Most methadone maintenance treatment patients are smokers, and methadone administration has been shown to increase cigarette smoking. Previous in vitro studies have shown that me...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12317

    authors： Talka R,Salminen O,Tuominen RK

    更新日期：2015-04-01 00:00:00

  • Involvement of regulations of nucleophosmin and nucleoporins in gambogic acid-induced apoptosis in Jurkat cells.

    abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2008.00292.x

    authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

    更新日期：2008-12-01 00:00:00

  • Acute CO poisoning is associated with impaired fibrinolysis and increased thrombin generation.

    abstract：:Carbon monoxide (CO) poisoning is a leading cause of unintentional poisoning deaths in many countries. In ex vivo studies, CO released from carbon monoxide-releasing molecules has been shown to attenuate fibrinolysis via increased alpha-2-antiplasmin activity. Hypofibrinolysis is associated with coronary ischaemia, wh...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 临床试验,杂志文章

    doi：10.1111/bcpt.12042

    authors： Gawlikowski T,Gomolka E,Piekoszewski W,Jawień W,Undas A

    更新日期：2013-05-01 00:00:00

  • Quantitative Assessment of Food Effect on the Pharmacokinetics of Nano-Crystallized Megestrol Acetate.

    abstract：:Megestrol acetate, an appetite stimulant with low bioavailability, shows increased bioavailability when taken together with food. However, the pharmacokinetic characteristics of megestrol acetate and its relation with food are not well understood. This study aimed to investigate the food effect on the pharmacokinetics...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 临床试验,杂志文章

    doi：10.1111/bcpt.12677

    authors： Guk J,Son H,Chae DW,Park K

    更新日期：2017-03-01 00:00:00

  • Meta-analysis of the effect of MDR1 C3435T polymorphism on cyclosporine pharmacokinetics.

    abstract：:The published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP C3435T on the pharmacokinetics of cyclosporine; thus, the aim was to conduct a meta-analysis of significant magnitude to investigate the influence of SNP C3435T on the pharmacokinetics of cyclosporine. A literature search was condu...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章,meta分析

    doi：10.1111/j.1742-7843.2008.00300.x

    authors： Jiang ZP,Wang YR,Xu P,Liu RR,Zhao XL,Chen FP

    更新日期：2008-11-01 00:00:00

  • Non-Clinical Pharmacokinetics, Prediction of Human Pharmacokinetics and First-in-Human Dose Selection for CNTO 5825, an Anti-Interleukin-13 Monoclonal Antibody.

    abstract：:CNTO 5825 is a human anti-interleukin-13 (IL-13) monoclonal antibody (mAb) that inhibits binding of human IL-13 to IL-13Rα1 and IL-13Rα2. The purpose of this investigation was to predict human pharmacokinetics (PK) of CNTO 5825 using different allometric approaches and non-clinical PK data in order to select the right...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12391

    authors： Nnane IP,Xu Z,Zhou H,Davis HM

    更新日期：2015-10-01 00:00:00

  • Templates for analysis of individual-level prescription data.

    abstract：:The advent of large population-based prescription databases has enabled us to study drug use with the individual user as our unit of analysis. This review presents three non-specific analytic templates that may be applied to individual-level prescription data. The ratio of prevalence odds to incidence rate can estimat...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章,评审

    doi：10.1111/j.1742-7843.2006.pto_257.x

    authors： Hallas J,Støvring H

    更新日期：2006-03-01 00:00:00

  • Antinociceptive activity of a new benzofuranone derived from a chalcone.

    abstract：:Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice. The new benzofuranone 4 ...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2009.00441.x

    authors： Padaratz P,Fracasso M,de Campos-Buzzi F,Corrêa R,Niero R,Delle Monache F,Cechinel-Filho V

    更新日期：2009-10-01 00:00:00

  • Functional Characterization of 22 CYP3A4 Protein Variants to Metabolize Ibrutinib In Vitro.

    abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12934

    authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

    更新日期：2018-04-01 00:00:00

  • Effects of antihypertensive and triglyceride-lowering agents on hepatic copper concentrations in rats with fatty liver disease.

    abstract：:Copper deficiency had been suggested to link between fructose-enriched diet (FED) and the development of non-alcoholic fatty liver disease (NAFLD). In this study, we characterized changes in hepatic copper concentrations and hepatic oxidative milieu, in rats with the metabolic syndrome and NAFLD as a result of FED wit...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12283

    authors： Ackerman Z,Skarzinski G,Grozovski M,Oron-Herman M,Sela BA

    更新日期：2014-12-01 00:00:00

  • Antimetastatic effects of licochalcone B on human bladder carcinoma T24 by inhibition of matrix metalloproteinases-9 and NF-кB activity.

    abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12273

    authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

    更新日期：2014-12-01 00:00:00

  • Trimidox induces apoptosis via cytochrome c release in NALM-6 human B cell leukaemia cells.

    abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2006.pto_188.x

    authors： Kanno S,Uwai K,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Takeshita M,Ohtake T,Kimura K,Ishikawa M

    更新日期：2006-01-01 00:00:00

  • Cardioprotective effect of sulphonated formononetin on acute myocardial infarction in rats.

    abstract：:This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2011.00676.x

    authors： Zhang S,Tang X,Tian J,Li C,Zhang G,Jiang W,Zhang Z

    更新日期：2011-06-01 00:00:00

  • In vitro studies investigating the interactions between degarelix, a decapeptide gonadotropin-releasing hormone blocker, and cytochrome P450.

    abstract：:The decapeptide degarelix is a novel competitive gonadotropin-releasing hormone receptor antagonist that has been approved for the treatment of advanced prostate cancer by the FDA and the EU authorities. In this study, the interaction of degarelix with human cytochrome P450 (CYP450) enzymes was investigated in vitro. ...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2011.00709.x

    authors： Sonesson A,Rasmussen BB

    更新日期：2011-09-01 00:00:00

  • A comparison of the reactivating and therapeutic efficacy of two newly developed oximes (k727 and k733) with oxime k203 and trimedoxime in tabun-poisoned rats and mice.

    abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12327

    authors： Kassa J,Sepsova V,Tumova M,Horova A,Musilek K

    更新日期：2015-04-01 00:00:00

  • Considerations for Pharmacoepidemiological Studies of Drug-Cancer Associations.

    abstract：:In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspecti...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章,评审

    doi：10.1111/bcpt.12946

    authors： Pottegård A,Friis S,Stürmer T,Hallas J,Bahmanyar S

    更新日期：2018-05-01 00:00:00

  • Acidification alters antiarrhythmic drug blockade of the ether-a-go-go-related Gene (HERG) Channels.

    abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2004.pto940503.x

    authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

    更新日期：2004-05-01 00:00:00

  • Applying concepts of generalizability theory on data from experimental pain studies to investigate reliability.

    abstract：:This work demonstrates how full modelling power in statistically mixed models can be used to study generalizability (reliability) coefficients of advanced data from human experimental pain studies utilizing placebo data from drug screening trials. This can be used to help optimizing outcome parameters from existing da...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章,随机对照试验

    doi：10.1111/j.1742-7843.2009.00408.x

    authors： Pryseley A,Ledent EY,Drewes AM,Staahl C,Olesen AE,Arendt-Nielsen L

    更新日期：2009-08-01 00:00:00

  • Neuroprotective effects of diazepam, carbamazepine, phenytoin and ketamine after pilocarpine-induced status epilepticus.

    abstract：:Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinject...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2009.00403.x

    authors： Cunha AO,Mortari MR,Liberato JL,dos Santos WF

    更新日期：2009-06-01 00:00:00

  • Pharmacovigilance Skills, Knowledge and Attitudes in our Future Doctors - A Nationwide Study in the Netherlands.

    abstract：:Pharmacovigilance centres monitor the safety of drugs, based on adverse drug reactions (ADRs) reported by doctors, pharmacists and pharmaceutical companies. However, the under-reporting of ADRs remains a major problem. Our aim was to investigate preparedness of future doctors for their role in pharmacovigilance, by as...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12712

    authors： Schutte T,Tichelaar J,Reumerman MO,van Eekeren R,Rissmann R,Kramers C,Richir MC,van Puijenbroek EP,van Agtmael MA,Education Committee\/Working Group Research in Education of the Dutch Society of Clinical Pharmacology and Biopharmacy (N

    更新日期：2017-05-01 00:00:00

  • Effect of betulinic acid on anticancer drug-resistant colon cancer cells.

    abstract：:Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irino...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/j.1742-7843.2007.00115.x

    authors： Jung GR,Kim KJ,Choi CH,Lee TB,Han SI,Han HK,Lim SC

    更新日期：2007-10-01 00:00:00

  • Conditioned Reward of Opioids, but not Psychostimulants, is Impaired in GABA-A Receptor δ Subunit Knockout Mice.

    abstract：:Extrasynaptic δ subunit-containing γ-aminobutyric acid type A receptors (δ-GABAA Rs) are emerging as targets for a number of neuropsychopharmacological drugs, including the direct GABA site agonist gaboxadol and neuroactive steroids. Among other regions, these δ-GABAA Rs are functionally expressed in the ventral tegme...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.13043

    authors： Siivonen MS,de Miguel E,Aaltio J,Manner AK,Vahermo M,Yli-Kauhaluoma J,Linden AM,Aitta-Aho T,Korpi ER

    更新日期：2018-11-01 00:00:00

  • Rho Kinase Inhibitor, Fasudil, Attenuates Contrast-induced Acute Kidney Injury.

    abstract：:In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12895

    authors： Wang Y,Zhang H,Yang Z,Miao D,Zhang D

    更新日期：2018-02-01 00:00:00

  • Metformin induces cytotoxicity by down-regulating thymidine phosphorylase and excision repair cross-complementation 1 expression in non-small cell lung cancer cells.

    abstract：:Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and growth, although the involved molecular mechanisms have not been elucidated. In many cancer cells, high expression of thymidine phosphorylase (TP) and Excision repair cross-complementation 1 (ERCC1) is associated with poor progno...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12052

    authors： Ko JC,Huang YC,Chen HJ,Tseng SC,Chiu HC,Wo TY,Huang YJ,Weng SH,Chiou RY,Lin YW

    更新日期：2013-07-01 00:00:00

  • Gene expression change in human dental pulp cells exposed to a low-level toxic concentration of triethylene glycol dimethacrylate: an RNA-seq analysis.

    abstract：:Dental composite resin restoration for defective tooth may lead unpolymerized resin monomers to be leached into dental pulp tissue. The aim of this study was to investigate the early gene expression change over time of human dental pulp cells (HDPCs) treated with a low-level toxic concentration of Triethylene Glycol D...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12197

    authors： Cho SG,Lee JW,Heo JS,Kim SY

    更新日期：2014-09-01 00:00:00

  • Toxic Epidermal Necrolysis After Exposure to Dithiocarbamate Fungicide Mancozeb.

    abstract：:Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous disease with high mortality. Dithiocarbamates (DTC) are organosulphur compounds widely used in agriculture, industry and households. We report a case of TEN after exposure to mancozeb in fungicide. A 48-year-old 75 kg b.w. man was admitted with fever...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12430

    authors： Zakharov S,Csomor J,Urbanek P,Pelclova D

    更新日期：2016-01-01 00:00:00

  • Paracelsus Revisited: The Dose Concept in a Complex World.

    abstract：:At the time that Paracelsus coined his famous dictum, 'What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison', embryonic toxicology was a fairly focused discipline that mainly dealt with occupational poisonings and side effects of...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 历史文章,杂志文章,评审

    doi：10.1111/bcpt.12622

    authors： Grandjean P

    更新日期：2016-08-01 00:00:00

  • Kolaviron, a natural antioxidant and anti-inflammatory phytochemical prevents dextran sulphate sodium-induced colitis in rats.

    abstract：:The beneficial effects of kolaviron, a natural biflavonoid from the seeds of Garcinia kola, have been attributed mainly to its antioxidant and anti-inflammatory effects. This study investigated these effects on dextran sulphate sodium (DSS)-induced ulcerative colitis in rats. Sulfasalazine served as standard reference...

    journal_title：Basic & clinical pharmacology & toxicology

    pub_type： 杂志文章

    doi：10.1111/bcpt.12050

    authors： Farombi EO,Adedara IA,Ajayi BO,Ayepola OR,Egbeme EE

    更新日期：2013-07-01 00:00:00