Pharmacovigilance Skills, Knowledge and Attitudes in our Future Doctors - A Nationwide Study in the Netherlands.

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. In patients for whom HCC could not be detected early, current treatments show poor tolerance and low efficacy. So, alternative therapies with good efficacy are urgently needed. The aim of this research was to evaluate the selective ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Seydi E,Rasekh HR,Salimi A,Mohsenifar Z,Pourahmad J

更新日期：2016-09-01 00:00:00

abstract：:Traditional non-steroidal anti-inflammatory drugs (NSAID) and selective cyclooxygenase-2 (COX-2) inhibitors are widely used in the treatment of pain, including bone fracture pain and orthopaedic post-operative pain. The gastrointestinal and cardiovascular adverse effects of NSAIDs are acknowledged, but their effects o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vuolteenaho K,Moilanen T,Moilanen E

更新日期：2008-01-01 00:00:00

abstract：:Mildronate is a cardioprotective drug that improves cardiac function during ischaemia and functions by lowering l-carnitine concentration in body tissues and modulating myocardial energy metabolism. The aim of the present study was to characterise cardiovascular function and liver condition after long-term mildronate ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liepinsh E,Kuka J,Svalbe B,Vilskersts R,Skapare E,Cirule H,Pugovics O,Kalvinsh I,Dambrova M

更新日期：2009-12-01 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...

journal_title：Basic & clinical pharmacology & toxicology

authors： Damkier P,Lassen D,Christensen MMH,Madsen KG,Hellfritzsch M,Pottegård A

更新日期：2019-01-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:The decapeptide degarelix is a novel competitive gonadotropin-releasing hormone receptor antagonist that has been approved for the treatment of advanced prostate cancer by the FDA and the EU authorities. In this study, the interaction of degarelix with human cytochrome P450 (CYP450) enzymes was investigated in vitro. ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sonesson A,Rasmussen BB

更新日期：2011-09-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) and MSC-derived small extracellular vesicles (sEVs) are promising candidates for cell-based and cell-free regenerative medicine, respectively. By virtue of their multiple lineage differentiation capacity, MSCs have been implicated as an ideal tool for bone and cartilage regeneration. Howe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang X,Thomsen P

更新日期：2021-01-01 00:00:00

abstract：:Our previous studies with the use of non-selective cyclooxygenase (COX) inhibitor, indomethacin, demonstrated that prostanoids produced during endotoxaemia increase inducible nitric oxide synthase (iNOS) protein expression and nitric oxide synthesis, and decrease cyctochrome P450 (CYP) 4A1 protein expression and CYP 4...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tunctan B,Korkmaz B,Cuez T,Kemal Buharalioglu C,Sahan-Firat S,Falck J,Malik KU

更新日期：2010-11-01 00:00:00

abstract：:Natural oils are extensively used in cosmetics and as treatment for a growing number of more or less specific ailments. Skin irritation and cases of allergy have repeatedly been described in the literature following exposure to these oils. The present study evaluated the extent to which three natural oils (eucalyptus ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nielsen JB

更新日期：2006-06-01 00:00:00

abstract：:Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample c...

journal_title：Basic & clinical pharmacology & toxicology

authors： Neuvonen M,Tarkiainen EK,Tornio A,Hirvensalo P,Tapaninen T,Paile-Hyvärinen M,Itkonen MK,Holmberg MT,Kärjä V,Männistö VT,Neuvonen PJ,Pihlajamäki J,Backman JT,Niemi M

更新日期：2018-03-01 00:00:00

abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ogur R,Uysal B,Ogur T,Yaman H,Oztas E,Ozdemir A,Hasde M

更新日期：2007-05-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:Dental composite resin restoration for defective tooth may lead unpolymerized resin monomers to be leached into dental pulp tissue. The aim of this study was to investigate the early gene expression change over time of human dental pulp cells (HDPCs) treated with a low-level toxic concentration of Triethylene Glycol D...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cho SG,Lee JW,Heo JS,Kim SY

更新日期：2014-09-01 00:00:00

abstract：:The constitutive endothelial nitric oxide synthase (eNOS) plays a major role in circulatory homoeostasis and shows genetic polymorphism. eNOS is expressed and functional in blood cells, including erythrocytes. There is limited knowledge about the consequences of eNOS genetic variability in haemorheological parameters ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Babaoglu MO,Dikmenoglu N,Ileri-Gurel E,Seringec N,Zoto T,Yasar U,Kayaalp SO,Bozkurt A

更新日期：2011-03-01 00:00:00

abstract：:There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mukherjee S,Saha N

更新日期：2018-03-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading inevitably to death in respiratory failure. ALS is a model condition for neurodegenerative disorders. Exposure to different agents dispersed in the environment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Roos PM,Dencker L

更新日期：2012-08-01 00:00:00

abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Möller J,Laflamme L,Söderberg Löfdal K

更新日期：2015-02-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of sodium nitrite (NaNO(2))-induced methemoglobinaemia on plasma ATP (adenosine triphosphate) and corresponding changes of blood-ionized magnesium (iMg(2+)) as well as total magnesium (tMg(2+)) in a time-dependent manner. This study was performed on male Sprague-...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rahman MM,Kim SJ,Kim GB,Hong CU,Lee YU,Kim SZ,Kim JS,Kang HS

更新日期：2009-11-01 00:00:00

abstract：:Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang H,Ju B,Zhang X,Zhu Y,Nie Y,Xu Y,Lei Q

更新日期：2017-06-01 00:00:00

abstract：:Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminif...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bjørklund G,Chirumbolo S,Dadar M,Pivina L,Lindh U,Butnariu M,Aaseth J

更新日期：2019-10-01 00:00:00

abstract：:Juglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, juglone has been shown to counteract apoptosis, for example, of neurons. In an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Calabrò S,Alzoubi K,Bissinger R,Jilani K,Faggio C,Lang F

更新日期：2015-06-01 00:00:00

abstract：:Vanishing bile duct syndrome is a severe cholestatic disease associated with toxic effects of medications. Stevens-Johnson syndrome is a hypersensitivity disorder that may also be caused by medications. We present a case of a 62-year-old male patient who developed vanishing bile duct syndrome a month after Stevens-Joh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Juricic D,Hrstic I,Radic D,Skegro M,Coric M,Vucelic B,Francetic I

更新日期：2010-01-01 00:00:00

abstract：:The essential oil of Alpinia zerumbet (EOAz) presents myorelaxant and antispasmodic actions on cardiac and smooth muscles. The aim of this study was to investigate the effect of EOAz on the skeletal muscle contraction in post-stroke spasticity. Fifteen adults with unilateral hemiparesis and spasticity resulting from s...

journal_title：Basic & clinical pharmacology & toxicology

authors： Maia MO,Dantas CG,Xavier Filho L,Cândido EA,Gomes MZ

更新日期：2016-01-01 00:00:00

abstract：:The present in vivo study investigated the genotoxicity of four dental resin monomers: triethyleneglycoldimethacrylate (TEGDMA), hydroxyethylmethacrylate (HEMA), urethanedimethacrylate (UDMA) and bisphenol A-glycidylmethacrylate (BisGMA). The Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster w...

journal_title：Basic & clinical pharmacology & toxicology

authors： Arossi GA,Lehmann M,Dihl RR,Reguly ML,de Andrade HH

更新日期：2010-02-01 00:00:00

abstract：:Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Graversen C,Malver LP,Kurita GP,Staahl C,Christrup LL,Sjøgren P,Drewes AM

更新日期：2015-05-01 00:00:00

abstract：:Mercaptopurine is a drug commonly used in the treatment of different types of cancer, especially acute lymphoblastic leukaemia, and autoimmune diseases such as ulcerative colitis or Crohn's disease and in patients receiving organ transplants. It is metabolized by three cytosolic enzymes. One of them, thiopurine S-meth...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saiz-Rodríguez M,Ochoa D,Belmonte C,Román M,Martínez-Ingelmo C,Ortega-Ruíz L,Sarmiento-Iglesias C,Herrador C,Abad-Santos F

更新日期：2019-04-01 00:00:00

abstract：:Despite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significan...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk S,Lund C,Clemmensen C

更新日期：2020-06-01 00:00:00

abstract：:Tamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30-100 times higher potency than the parent drug, no previous study has compared the effects produced by tamoxifen and its metab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Montenegro MF,Pessa LR,Gomes VA,Desta Z,Flockhart DA,Tanus-Santos JE

更新日期：2009-05-01 00:00:00

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00