Myricetin Selectively Induces Apoptosis on Cancerous Hepatocytes by Directly Targeting Their Mitochondria.

abstract：:Vascular networks are dynamic structures, adapting to changing conditions by structural remodelling of vessel diameters and by growth of new vessels and regression of existing vessels. The vast number of blood vessels in the circulatory system, more than 10⁹, implies that vessels' arrangement and structure are not und...

journal_title：Basic & clinical pharmacology & toxicology

authors： Secomb TW,Dewhirst MW,Pries AR

更新日期：2012-01-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is gene...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bate A,Edwards IR

更新日期：2006-03-01 00:00:00

abstract：:Juglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, juglone has been shown to counteract apoptosis, for example, of neurons. In an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Calabrò S,Alzoubi K,Bissinger R,Jilani K,Faggio C,Lang F

更新日期：2015-06-01 00:00:00

abstract：:DOV 216,303, an inhibitor of serotonin, noradrenaline and dopamine reuptake, belongs to a new line of drugs called 'triple reuptake inhibitors' that have been proposed for treatment of depression. The addictive drug cocaine has similar mechanism of action and exerts rewarding effects by blocking reuptake of dopamine, ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sørensen G,Husum H,Brennum LT,Bundgaard C,Montezinho LC,Mørk A,Wörtwein G,Woldbye DP

更新日期：2014-06-01 00:00:00

abstract：:Vitamin K antagonists (VKA) are highly effective anticoagulants but their use is hampered by multiple interactions with food and medicine and a narrow therapeutic range. The large variation in dose requirements has led to the development of several dosing algorithms based on pharmacogenetic and clinical variables. In ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Skov J,Bladbjerg EM,Rasmussen MA,Sidelmann JJ,Leppin A,Jespersen J

更新日期：2012-02-01 00:00:00

abstract：:The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) involved the Food and Drug Administration, the National Toxicology Program and 14 academic investigators funded by the National Institute of Environmental Health Sciences. Two key questions to be answered by CLARITY-BPA were as follo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vom Saal FS

更新日期：2019-08-01 00:00:00

abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

journal_title：Basic & clinical pharmacology & toxicology

authors： Iversen TZ,Andersen MH,Svane IM

更新日期：2015-01-01 00:00:00

abstract：:Nicotine-methadone interactions have been studied in human beings and in various experimental settings regarding addiction, reward and pain. Most methadone maintenance treatment patients are smokers, and methadone administration has been shown to increase cigarette smoking. Previous in vitro studies have shown that me...

journal_title：Basic & clinical pharmacology & toxicology

authors： Talka R,Salminen O,Tuominen RK

更新日期：2015-04-01 00:00:00

abstract：:The present study investigated the improving effect of cucurbitacin B on liver fibrosis induced by concanavalin A in mice and explored its possible mechanism. AST, ALT and TB were detected by kits. ELISA was performed to detect the levels of IL 5, IL 6, IL 13 and TNF-α in serum. Haematoxylin-eosin (HE) staining and Ma...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang L,Ao Q,Zhong Q,Li W,Li W

更新日期：2020-11-01 00:00:00

abstract：:Pain involves responses in which both peripheral and central mechanisms contribute to the generation of pain. Pre-clinical laboratory data have supported that a topical formulation of combined diclofenac and methadone (Diclometh) may alleviate local pain, and potentially, the side effect profile should be low. We hypo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Larsen IM,Drewes AM,Olesen AE

更新日期：2018-08-01 00:00:00

abstract：:Doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. Selected...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wattanapitayakul SK,Chularojmontri L,Herunsalee A,Charuchongkolwongse S,Niumsakul S,Bauer JA

更新日期：2005-01-01 00:00:00

abstract：:Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord. The aim of the present study was to ascertain whether this pattern of COX-2 and COX-1 expression applies also to other pain conditions induced by surgical proc...

journal_title：Basic & clinical pharmacology & toxicology

authors： Prochazkova M,Dolezal T,Sliva J,Krsiak M

更新日期：2006-08-01 00:00:00

abstract：:Angiogenic therapy is one of the new treatments of ischaemic heart disease. Oestrogen has angiogenic properties under hypoxic condition, and if oestrogen also induces angiogenesis under normoxic condition, it could be used in combination with other angiogenic therapies in the treatment of ischaemic heart disease. In t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nematbakhsh M,Ghadesi M,Hosseinbalam M,Khazaei M,Gharagozloo M,Dashti G,Rajabi P,Rafieian S

更新日期：2008-09-01 00:00:00

abstract：:Ponesimod, a selective S1P1 receptor modulator, is a potential therapeutic agent for autoimmune disorders. The impact of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of ponesimod and its inactive metabolites, ACT-204426 and ACT-338375, was evaluated. Two separate single-centre, open-lab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guérard N,Zwingelstein C,Hoch M,Dingemanse J

更新日期：2016-05-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is associated with several skeletal alterations, particularly in conditions of poor glycaemic control. Insulin therapy is the major conservative treatment for T1DM; however, the effects of this hormone on bone markers of T1DM rats are limited, and the regulatory mechanisms remain elusiv...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bortolin RH,Freire Neto FP,Arcaro CA,Bezerra JF,da Silva FS,Ururahy MA,Souza KS,Lima VM,Luchessi AD,Lima FP,Lia Fook MV,da Silva BJ,Almeida MD,Abreu BJ,de Rezende LA,de Rezende AA

更新日期：2017-03-01 00:00:00

abstract：:Cisplatin and other platinum complexes are important chemotherapeutic agents and useful in the treatment for several cancers such as prostate, ovarian and testis. However, severe side effects including reproductive toxicity of cisplatin and other platinum complex cause limitations in their clinical usage. In this cont...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ciftci O,Beytur A,Cakir O,Gurbuz N,Vardi N

更新日期：2011-11-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading inevitably to death in respiratory failure. ALS is a model condition for neurodegenerative disorders. Exposure to different agents dispersed in the environment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Roos PM,Dencker L

更新日期：2012-08-01 00:00:00

abstract：:This retrospective study investigated whether the serum albumin (SA) concentration at presentation is associated with mortality and the mechanism underlying the association. This study enrolled 217 patients poisoned with organophosphate (OP). Hypoalbuminemia (albumin <3.5 g/dL) at presentation was identified in 18.4% ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Noh E,Moon JM,Chun BJ,Cho YS,Ryu S,Kim D

更新日期：2020-12-11 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pereira P,de Oliveira PA,Ardenghi P,Rotta L,Henriques JA,Picada JN

更新日期：2006-11-01 00:00:00

abstract：:Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is li...

journal_title：Basic & clinical pharmacology & toxicology

authors： Király I,Pataricza J,Bajory Z,Simonsen U,Varro A,Papp JG,Pajor L,Kun A

更新日期：2013-07-01 00:00:00

abstract：:Tamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30-100 times higher potency than the parent drug, no previous study has compared the effects produced by tamoxifen and its metab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Montenegro MF,Pessa LR,Gomes VA,Desta Z,Flockhart DA,Tanus-Santos JE

更新日期：2009-05-01 00:00:00

abstract：:Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, poor metabolizers (PM) and the remainder with preserved CYP2D6 activity, extensive metabolizers ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zwisler ST,Enggaard TP,Noehr-Jensen L,Pedersen RS,Mikkelsen S,Nielsen F,Brosen K,Sindrup SH

更新日期：2009-04-01 00:00:00

abstract：:Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and growth, although the involved molecular mechanisms have not been elucidated. In many cancer cells, high expression of thymidine phosphorylase (TP) and Excision repair cross-complementation 1 (ERCC1) is associated with poor progno...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ko JC,Huang YC,Chen HJ,Tseng SC,Chiu HC,Wo TY,Huang YJ,Weng SH,Chiou RY,Lin YW

更新日期：2013-07-01 00:00:00

abstract：:In the present study, we investigated the hepatoprotective effects of salvianolic acid A, a novel antioxidant, against oxidative stress and acute liver injury induced by carbon tetrachloride (CCl(4)) in rats, and the mechanisms underlying its protective effects. Administration of CCl(4) to rats caused severe hepatic d...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wu ZM,Wen T,Tan YF,Liu Y,Ren F,Wu H

更新日期：2007-02-01 00:00:00

abstract：:Current treatment of pulmonary arterial hypertension (PAH) targets three signalling pathways: the nitric oxide (NO) pathway, the endothelin pathway and the prostacyclin pathway. Riociguat is a soluble guanylate cyclase stimulator, acting via the NO pathway in a new way: unlike other common drugs targeting this pathway...

journal_title：Basic & clinical pharmacology & toxicology

authors： Toxvig AK,Wehland M,Grimm D,Infanger M,Krüger M

更新日期：2019-09-01 00:00:00

abstract：:Rapamycin is a macrocyclic lactone currently used for the treatment of cancer and for the prevention of transplant rejection. The primary pharmacological mode of action of rapamycin occurs through the inhibition (blocking) of the mammalian target of rapamycin (mTOR). By doing so, rapamycin interferes with the phosphoi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fagone P,Donia M,Mangano K,Quattrocchi C,Mammana S,Coco M,Libra M,McCubrey JA,Nicoletti F

更新日期：2013-01-01 00:00:00

abstract：:Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fábián K,Puskás R,Kakuk T,Prés L,Fejes D,Szegedi Z,Rojkó L,Szállási Z,Döme B,Pipek O,Moldvay J

更新日期：2018-01-01 00:00:00