Abstract：
:This retrospective study investigated whether the serum albumin (SA) concentration at presentation is associated with mortality and the mechanism underlying the association. This study enrolled 217 patients poisoned with organophosphate (OP). Hypoalbuminemia (albumin <3.5 g/dL) at presentation was identified in 18.4% of the patients poisoned with OP. The hypoalbuminemia group experienced a more complicated clinical course and had a higher mortality rate than the normoalbuminemia and hyperalbuminemia groups. The SA concentration correlated with the CRP level at presentation but not with the body mass index in patients with OP poisoning. Furthermore, the change in the SA concentration during the first 24 hours also correlated with the change in BuChE activity in patients with fenitrothion poisoning. The SA concentration at presentation was independently associated with mortality after adjusting for inflammation and nutritional status. This study showed that the SA concentration at presentation is associated with the mortality risk of patients poisoned with OP. This association is independent of inflammation and nutritional status in OP poisoning, and in particular, the protective effect of SA might contribute to this association in fenitrothion poisoning. These results should be validated.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Noh E,Moon JM,Chun BJ,Cho YS,Ryu S,Kim Ddoi
10.1111/bcpt.13546subject
Has Abstractpub_date
2020-12-11 00:00:00eissn
1742-7835issn
1742-7843pub_type
杂志文章abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00458.x
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_530.x
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12946
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pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
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pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2011.00801.x
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_388.x
更新日期：2006-06-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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更新日期：2018-01-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,meta分析
doi：10.1111/j.1742-7843.2008.00300.x
更新日期：2008-11-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12349
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2005.pto_195.x
更新日期：2005-12-01 00:00:00
abstract：:The OECD GD 129 BALB/c 3T3 neutral red uptake (NRU) assay is a standardized test method for estimating starting dose for an acute oral systemic toxicity test in rodents. Mouse BALB/c 3T3 fibroblasts are the most commonly used cells in the NRU assay. We have previously transferred and validated BALB/c 3T3 NRU assay in ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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abstract：:Osteoarthritis (OA) and the non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve OA-associated pain have been linked independently to increased cardiovascular risk. We examined the risk of cardiovascular events associated with NSAID use in patients with OA. We employed linked nationwide administrative regist...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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