Human BJ Fibroblasts is an Alternative to Mouse BALB/c 3T3 Cells in In Vitro Neutral Red Uptake Assay.

abstract：:Our previous studies with the use of non-selective cyclooxygenase (COX) inhibitor, indomethacin, demonstrated that prostanoids produced during endotoxaemia increase inducible nitric oxide synthase (iNOS) protein expression and nitric oxide synthesis, and decrease cyctochrome P450 (CYP) 4A1 protein expression and CYP 4...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tunctan B,Korkmaz B,Cuez T,Kemal Buharalioglu C,Sahan-Firat S,Falck J,Malik KU

更新日期：2010-11-01 00:00:00

abstract：:Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives of the present study were to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for simvastatin and to evaluate its usefulness in predicting the dose-response relationship of simvastatin...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim J,Ahn BJ,Chae HS,Han S,Doh K,Choi J,Jun YK,Lee YW,Yim DS

更新日期：2011-09-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder that is characterized by the accumulation of senile plaques containing amyloid β (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein in the brain. Oxidative stress has been proposed to mediate Aβ-induced neurotoxicity. In that regard, we eval...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mohammadi M,Yazdanparast R

更新日期：2011-06-01 00:00:00

abstract：:In the present study, we investigated the hepatoprotective effects of salvianolic acid A, a novel antioxidant, against oxidative stress and acute liver injury induced by carbon tetrachloride (CCl(4)) in rats, and the mechanisms underlying its protective effects. Administration of CCl(4) to rats caused severe hepatic d...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wu ZM,Wen T,Tan YF,Liu Y,Ren F,Wu H

更新日期：2007-02-01 00:00:00

abstract：:Polyphenols are ubiquitous substances in human diet. Their antioxidative, antiinflammatory and antiviral effects are of interest for human health, and polyphenols such as luteolin are used at high concentrations in food supplements. Luteolin is metabolized to glucuronides, but also to methylated derivatives. For examp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Michels G,Mohamed GA,Weber N,Chovolou Y,Kampkötter A,Wätjen W,Proksch P

更新日期：2006-02-01 00:00:00

abstract：:There is an obvious urgent need to find effective and safe therapies to prevent both recurrence and progression of bladder cancer. In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-ka...

journal_title：Basic & clinical pharmacology & toxicology

authors： Li J,Cheng Y,Qu W,Sun Y,Wang Z,Wang H,Tian B

更新日期：2011-02-01 00:00:00

abstract：:Newly developed acetylcholinesterase reactivators K117 [1,5-bis(4-hydroxyiminomethylpyridinium)-3-oxapentane dichloride] and K127 [(1-(4-hydroxyiminomethylpyridinium)-5-(4-carbamoylpyridinium)-3-oxapentane dibromide)] were tested for their potency to reactivate tabun-inhibited human brain cholinesterases. Pralidoxime ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kuca K,Cabal J,Jung YS,Musilek K,Soukup O,Jun D,Pohanka M,Musilova L,Karasová J,Novotný L,Hrabinova M

更新日期：2009-09-01 00:00:00

abstract：:In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang Y,Zhang H,Yang Z,Miao D,Zhang D

更新日期：2018-02-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading inevitably to death in respiratory failure. ALS is a model condition for neurodegenerative disorders. Exposure to different agents dispersed in the environment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Roos PM,Dencker L

更新日期：2012-08-01 00:00:00

abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...

journal_title：Basic & clinical pharmacology & toxicology

authors： Almeida IF,Fernandes E,Lima JL,Costa PC,Bahia MF

更新日期：2009-10-01 00:00:00

abstract：:Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang H,Ju B,Zhang X,Zhu Y,Nie Y,Xu Y,Lei Q

更新日期：2017-06-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...

journal_title：Basic & clinical pharmacology & toxicology

authors： Damkier P,Lassen D,Christensen MMH,Madsen KG,Hellfritzsch M,Pottegård A

更新日期：2019-01-01 00:00:00

abstract：:Pain involves responses in which both peripheral and central mechanisms contribute to the generation of pain. Pre-clinical laboratory data have supported that a topical formulation of combined diclofenac and methadone (Diclometh) may alleviate local pain, and potentially, the side effect profile should be low. We hypo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Larsen IM,Drewes AM,Olesen AE

更新日期：2018-08-01 00:00:00

abstract：:This retrospective study investigated whether the serum albumin (SA) concentration at presentation is associated with mortality and the mechanism underlying the association. This study enrolled 217 patients poisoned with organophosphate (OP). Hypoalbuminemia (albumin <3.5 g/dL) at presentation was identified in 18.4% ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Noh E,Moon JM,Chun BJ,Cho YS,Ryu S,Kim D

更新日期：2020-12-11 00:00:00

abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pereira P,de Oliveira PA,Ardenghi P,Rotta L,Henriques JA,Picada JN

更新日期：2006-11-01 00:00:00

abstract：:The use of herbal or natural medicines for the treatment of various disorders has a long and extensive history. Many of these herbal medicines are finding their way onto the world market as alternatives to prescribed drugs currently available to treat various disorders/ailments. In particular, hyperlipidaemia is a maj...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang TH,Kota BP,Razmovski V,Roufogalis BD

更新日期：2005-01-01 00:00:00

abstract：:Cytochrome P450 2C8 (CYP2C8) plays important roles in the metabolism of various drugs, including the anti-cancer drug, paclitaxel. We recently identified two novel CYP2C8 alleles (CYP2C8*13 and CYP2C8*14; wild-type, CYP2C8*1A) with non-synonymous single nucleotide polymorphisms in a Japanese population. To precisely i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanioka N,Matsumoto K,Saito Y,Narimatsu S

更新日期：2010-07-01 00:00:00

abstract：:Whilst mitotic rat embryonic cardiomyoblast-derived H9c2 cells have been widely used as a model system to study the protective mechanisms associated with flavonoids, they are not fully differentiated cardiac cells. Hence, the aim of this study was to investigate the cardioprotective and cardiotoxic actions of querceti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Daubney J,Bonner PL,Hargreaves AJ,Dickenson JM

更新日期：2015-02-01 00:00:00

abstract：:Mercaptopurine is a drug commonly used in the treatment of different types of cancer, especially acute lymphoblastic leukaemia, and autoimmune diseases such as ulcerative colitis or Crohn's disease and in patients receiving organ transplants. It is metabolized by three cytosolic enzymes. One of them, thiopurine S-meth...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saiz-Rodríguez M,Ochoa D,Belmonte C,Román M,Martínez-Ingelmo C,Ortega-Ruíz L,Sarmiento-Iglesias C,Herrador C,Abad-Santos F

更新日期：2019-04-01 00:00:00

abstract：:Interest in proteomics as a tool for drug development and a myriad of other applications continues to expand at a rapid rate. Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Elrick MM,Walgren JL,Mitchell MD,Thompson DC

更新日期：2006-05-01 00:00:00

abstract：:The post-injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60-year-old Caucasian, schizophrenic, non-smoker and underweight [body mass index (BMI), 18.2 kg/m(2) ] women after the fourth intramuscular injection of 405 mg olanzapine pamoate. Clinical symptoms of PDSS were similar to those of acute...

journal_title：Basic & clinical pharmacology & toxicology

authors： Łukasik-Głębocka M,Sommerfeld K,Teżyk A,Panieński P,Żaba C,Zielińska-Psuja B

更新日期：2015-09-01 00:00:00

abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

journal_title：Basic & clinical pharmacology & toxicology

authors： Iversen TZ,Andersen MH,Svane IM

更新日期：2015-01-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays a pathogenic role in diabetic nephropathy (DN). Rosmarinic acid (RA) is a naturally occurring phenolic acid. This study was conducted to investigate the efficacy of RA on DN and to elucidate the potential mechanism. High glucose (HG)-stimulated cultured human renal proximal...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jiang WL,Xu Y,Zhang SP,Hou J,Zhu HB

更新日期：2012-04-01 00:00:00

abstract：:Nicotine-methadone interactions have been studied in human beings and in various experimental settings regarding addiction, reward and pain. Most methadone maintenance treatment patients are smokers, and methadone administration has been shown to increase cigarette smoking. Previous in vitro studies have shown that me...

journal_title：Basic & clinical pharmacology & toxicology

authors： Talka R,Salminen O,Tuominen RK

更新日期：2015-04-01 00:00:00

abstract：:This study investigated the impact of prolonged nicotine administration on myocardial susceptibility to ischaemia-reperfusion (I/R) injury in a rat model and determined whether nicotine affects mitochondrial reactive oxygen species (ROS) production and permeability transition in rat hearts. Sprague-Dawley rats were ad...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ramalingam A,Mohd Fauzi N,Budin SB,Zainalabidin S

更新日期：2021-02-01 00:00:00

abstract：:Radial artery frequently develops spasm and requires vasodilator therapy during coronary artery bypass graft surgery (CABG). Levosimendan was recently shown to oppose 5-hydroxytryptamine-induced contraction of radial artery (RA) grafts. The aim of the present study was to explore whether levosimendan retains its vasod...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ambrus N,Szolnoky J,Pollesello P,Kun A,Varró A,Papp JG,Pataricza J

更新日期：2012-03-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. In patients for whom HCC could not be detected early, current treatments show poor tolerance and low efficacy. So, alternative therapies with good efficacy are urgently needed. The aim of this research was to evaluate the selective ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Seydi E,Rasekh HR,Salimi A,Mohsenifar Z,Pourahmad J

更新日期：2016-09-01 00:00:00

abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Sepsova V,Tumova M,Horova A,Musilek K

更新日期：2015-04-01 00:00:00

abstract：:This study investigates the oxidative damage of biomolecules in livers of mice treated with morphine intraperitoneally. The oxidative damage of DNA as measured by single cell electrophoresis and high-performance liquid chromatography equipped with electrochemical and UV detection, the protein carbonyl content was meas...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang YT,Zheng QS,Pan J,Zheng RL

更新日期：2004-08-01 00:00:00