Natural oils affect the human skin integrity and the percutaneous penetration of benzoic acid dose-dependently.

abstract：:Although atracurium is a widely used neuromuscular blocker, we still lack knowledge regarding some of its cellular mechanisms of action. Thus, similar to other clinically used blockers atracurium induces, both in vivo and in vitro, fade of the tetanic contraction. However, the cellular mechanisms underlying this tetan...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nascimento DC,Serra CS,Oliveira AC

更新日期：2004-07-01 00:00:00

abstract：:Microdialysis is a valuable tool to measure tissue responses. We hypothesized that skeletal muscle metabolism can be modulated by microdialysis applied drugs which alter cytosolic calcium concentration. With approval of the local animal care committee, the hind limbs of sacrificed male Sprague Dawley rats were perfuse...

journal_title：Basic & clinical pharmacology & toxicology

authors： Schuster F,Tas P,Müller R,Roewer N,Anetseder M

更新日期：2006-04-01 00:00:00

abstract：:The present study investigated the improving effect of cucurbitacin B on liver fibrosis induced by concanavalin A in mice and explored its possible mechanism. AST, ALT and TB were detected by kits. ELISA was performed to detect the levels of IL 5, IL 6, IL 13 and TNF-α in serum. Haematoxylin-eosin (HE) staining and Ma...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang L,Ao Q,Zhong Q,Li W,Li W

更新日期：2020-11-01 00:00:00

abstract：:In recent years, several online tools have appeared capable of identifying potential plagiarism in science. While such tools may help to maintain or even increase the originality and ethical quality of the scientific literature, no apparent consensus exists among editors on the degree of plagiarism or self-plagiarism ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lykkesfeldt J

更新日期：2016-08-01 00:00:00

abstract：:The OECD GD 129 BALB/c 3T3 neutral red uptake (NRU) assay is a standardized test method for estimating starting dose for an acute oral systemic toxicity test in rodents. Mouse BALB/c 3T3 fibroblasts are the most commonly used cells in the NRU assay. We have previously transferred and validated BALB/c 3T3 NRU assay in ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mannerström M,Toimela T,Sarkanen JR,Heinonen T

更新日期：2017-09-01 00:00:00

abstract：:δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the rec...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk-Petersen CB,Søgaard R,Madsen KL,Klein AB,Frølund B,Wellendorph P

更新日期：2017-08-01 00:00:00

abstract：:In the last decades, a number of new antimuscarinic drugs have been introduced for treatment of the overactive bladder (OAB), defined symptomatically (OAB syndrome) or urodynamically (detrusor overactivity). Recently, three new drug principles have been approved for clinical use, the β3 -adrenoceptor agonist, mirabegr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Andersson KE

更新日期：2016-10-01 00:00:00

abstract：:Effect of carbon tetrachloride (CCl(4)) pretreatment on the biotransformation and elimination of acetaminophen were examined in male mice. A 24 hr initial dose of CCl(4) (0.05 ml/kg, intraperitioneally) reduced the induction of hepatotoxicity resulting from acetaminophen treatment (350 mg/kg, intraperitoneally) as det...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yim HK,Jung YS,Kim SY,Kim YC

更新日期：2006-02-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) is considered as the limiting enzyme of thiopurine metabolism for the formation of 6-thioguanine nucleotides (6-TGN). No data are available on the influence of RBC IMPDH activity on the metabolism of thiopurine drugs in individuals with IBD. The aims of this study were as fo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Citterio-Quentin A,El Mahmoudi A,Perret T,Conway A,Ryan A,Beringer A,Lachaux A,Boulieu R

更新日期：2019-05-01 00:00:00

abstract：:Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, poor metabolizers (PM) and the remainder with preserved CYP2D6 activity, extensive metabolizers ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zwisler ST,Enggaard TP,Noehr-Jensen L,Pedersen RS,Mikkelsen S,Nielsen F,Brosen K,Sindrup SH

更新日期：2009-04-01 00:00:00

abstract：:To study the influence of single or repeated low-level sarin inhalation exposure on immune functions, inbred BALB/c mice were exposed to low clinically asymptomatic concentrations of sarin for 60 min. in the inhalation chamber. The evaluation of immune functions was carried out using phenotyping of CD3 (T-lymphocytes)...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Krocová Z,Sevelová L,Sheshko V,Kasalová I,Neubauerová V

更新日期：2004-03-01 00:00:00

abstract：:In view of paediatric drug development, regulatory authorities often request safety studies in juvenile animals, including minipigs. Unfortunately, knowledge on the ontogeny of the biotransformation processes in animal models remains scarce and impedes a correct interpretation of the toxicity findings. CYP3A4 is one o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Peer E,De Bock L,Boussery K,Van Bocxlaer J,Casteleyn C,Van Ginneken C,Van Cruchten S

更新日期：2015-11-01 00:00:00

abstract：:The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mogensen S,Sverrisdóttir E,Sveinsdóttir K,Treldal C,Jensen K,Jensen AB,Kristensen CA,Jacobsen J,Kreilgaard M,Petersen J,Andersen O

更新日期：2017-01-01 00:00:00

abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2007-11-01 00:00:00

abstract：:At the time that Paracelsus coined his famous dictum, 'What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison', embryonic toxicology was a fairly focused discipline that mainly dealt with occupational poisonings and side effects of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P

更新日期：2016-08-01 00:00:00

abstract：:Pharmacokinetic/pharmacodynamic (PK/PD) models can be useful tools in new drug development and also optimal drug therapy in patients. This study was designed to develop a PK/PD model of sitagliptin based on the physiology of incretin. The PK/PD data included information derived from two different studies. Study 1 was ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim BH,Kim SE,Kang D,Lim KS,Kim JR,Jang IJ,Shin SG,Yoon SH,Cho JY,Yu KS

更新日期：2013-08-01 00:00:00

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00

abstract：:Gastric carcinoma (GC) is a pernicious neoplasm with high morbidity and mortality. Sinomenine (SIN) has long been exploited to heal rheumatoid arthritis. Recently, SIN has been discovered to exert the antitumour functions in diverse cancers. However, the impacts of SIN on GC remain indistinct. We attempted to expose t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yuan H,Zhang J,Li F,Li W,Wang H

更新日期：2019-11-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder that is characterized by the accumulation of senile plaques containing amyloid β (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein in the brain. Oxidative stress has been proposed to mediate Aβ-induced neurotoxicity. In that regard, we eval...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mohammadi M,Yazdanparast R

更新日期：2011-06-01 00:00:00

abstract：:The antifungal ionophore nystatin dissipates the Na(+) and K(+) gradients across the cell membrane, leading to cellular gain of Na(+) and cellular loss of K(+) . The increase of cellular Na(+) concentration may result in Ca(2+) accumulation in exchange for Na(+) . Increase of cytosolic Ca(2+) activity ([Ca(2+) ]i ) an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Malik A,Bissinger R,Jilani K,Lang F

更新日期：2015-01-01 00:00:00

abstract：:The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid (TMCA) to reverse it. Reversal of liver fibrosis was studied in male Wistar rats after one, two or three months of CCl(...

journal_title：Basic & clinical pharmacology & toxicology

authors： Muriel P,Moreno MG,Hernández Mdel C,Chávez E,Alcantar LK

更新日期：2005-05-01 00:00:00

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. In patients for whom HCC could not be detected early, current treatments show poor tolerance and low efficacy. So, alternative therapies with good efficacy are urgently needed. The aim of this research was to evaluate the selective ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Seydi E,Rasekh HR,Salimi A,Mohsenifar Z,Pourahmad J

更新日期：2016-09-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) has been connected to learning, memory and mood. Changes in serum or plasma POP activity have been linked to psychiatric disorders. POP has been thought to interfere in these conditions by cleaving neuroactive peptides or via the phosphatidylinositol second messenger system. However, little...

journal_title：Basic & clinical pharmacology & toxicology

authors： Peltonen I,Männistö PT

更新日期：2011-01-01 00:00:00

abstract：:Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is li...

journal_title：Basic & clinical pharmacology & toxicology

authors： Király I,Pataricza J,Bajory Z,Simonsen U,Varro A,Papp JG,Pajor L,Kun A

更新日期：2013-07-01 00:00:00

abstract：:Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated with this, we examined the frequencies of 29 SNPs located in candidate genes related to opioid pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Christoffersen DJ,Damkier P,Feddersen S,Möller S,Thomsen JL,Brasch-Andersen C,Brøsen K

更新日期：2016-10-01 00:00:00

abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

更新日期：2018-04-01 00:00:00

abstract：:Angiogenic therapy is one of the new treatments of ischaemic heart disease. Oestrogen has angiogenic properties under hypoxic condition, and if oestrogen also induces angiogenesis under normoxic condition, it could be used in combination with other angiogenic therapies in the treatment of ischaemic heart disease. In t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nematbakhsh M,Ghadesi M,Hosseinbalam M,Khazaei M,Gharagozloo M,Dashti G,Rajabi P,Rafieian S

更新日期：2008-09-01 00:00:00