Abstract：
:Vitamin D deficiency seems to be implicated in the onset and progression of some autoimmune disorders. No previous study has investigated vitamin D homeostasis in post-partum thyroiditis. We compared 25-hydroxyvitamin D and parathyroid hormone (PTH) levels between four groups of non-lactating women who gave birth within 12 months before the beginning of the study: hypothyroid women with post-partum thyroiditis (group A; n = 14), euthyroid females with post-partum thyroiditis (group B; n = 14), women with non-autoimmune hypothyroidism (group C; n = 16) and healthy euthyroid females without thyroid autoimmunity (group D; n = 15). In the second part of the study, groups A and C were treated for 6 months with L-thyroxine. Serum levels of 25-hydroxyvitamin D were lower, while PTH higher in patients with post-partum thyroiditis than in patients without thyroid autoimmunity. They were also lower (25-hydroxyvitamin D) or higher (PTH) in group A than in group B, as well as in group C in comparison with group D. L-thyroxine treatment increased 25-hydroxyvitamin D and reduced PTH levels only in hypothyroid women with post-partum thyroiditis. Baseline levels of 25-hydroxyvitamin D correlated with thyroid antibody titres, thyroid function and circulating PTH levels, while the effect of L-thyroxine on serum levels of this vitamin correlated with the changes in thyroid antibody titres and PTH levels. The results of our study suggest the association of vitamin D status with post-partum thyroiditis and L-thyroxine treatment of this disorder.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Krysiak R,Kowalska B,Okopien Bdoi
10.1111/bcpt.12349subject
Has Abstractpub_date
2015-06-01 00:00:00pages
503-7issue
6eissn
1742-7835issn
1742-7843journal_volume
116pub_type
杂志文章abstract：:This study investigated the antinociceptive effects of zerumbone in chemical behavioural models of nociception in mice. Zerumbone given through intraperitoneal route (i.p.) produced dose-related antinociception when assessed on acetic acid-induced abdominal writhing test in mice. In addition, the i.p. administration o...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00635.x
更新日期：2011-03-01 00:00:00
abstract：:This study investigates the oxidative damage of biomolecules in livers of mice treated with morphine intraperitoneally. The oxidative damage of DNA as measured by single cell electrophoresis and high-performance liquid chromatography equipped with electrochemical and UV detection, the protein carbonyl content was meas...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2004.950202.x
更新日期：2004-08-01 00:00:00
abstract：:Quercetin is a plant flavonoid with several biological activities. This study aimed to describe quercetin effects on contractile and electrophysiological properties of the cardiac muscle as well as on calcium handling. Quercetin elicited positive inotropism that was significantly reduced by propranolol indicating an i...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12743
更新日期：2017-06-01 00:00:00
abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2007.00130.x
更新日期：2007-11-01 00:00:00
abstract：:To clarify the action of a side-effect of phenylbutazone, we investigated the inactivation of alpha(1)-antiproteinase induced by phenylbutazone in the presence of horseradish peroxidase (HRP) and H(2)O(2) (HRP-H(2)O(2)). The activity of alpha(1)-antiproteinase was rapidly lost during the interaction of phenylbutazone ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_473.x
更新日期：2006-09-01 00:00:00
abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.13152
更新日期：2019-01-01 00:00:00
abstract：:Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinject...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00403.x
更新日期：2009-06-01 00:00:00
abstract：:There is an obvious urgent need to find effective and safe therapies to prevent both recurrence and progression of bladder cancer. In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-ka...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00613.x
更新日期：2011-02-01 00:00:00
abstract：:In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12895
更新日期：2018-02-01 00:00:00
abstract：:Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, poor metabolizers (PM) and the remainder with preserved CYP2D6 activity, extensive metabolizers ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1742-7843.2009.00378.x
更新日期：2009-04-01 00:00:00
abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2004-01-01 00:00:00
abstract：:Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study with the objective to evaluate the...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12722
更新日期：2017-04-01 00:00:00
abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_533.x
更新日期：2006-11-01 00:00:00
abstract：:The antithrombotic and antiplatelet activities of Korean red ginseng extract (KRGE) were examined on rat carotid artery thrombosis in vivo and platelet aggregation in vitro and ex vivo. The KRGE significantly prevented rat carotid arterial thrombosis in vivo in a dose-dependent manner. Administration of the KRGE to ra...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.00033.x
更新日期：2007-03-01 00:00:00
abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2005.pto_195.x
更新日期：2005-12-01 00:00:00
abstract：:Concurrent administration of chloramphenicol (CAP) with multivitamin-haematinics complex (MHC) is a common practice to cushioning anticipated anaemic effect of CAP in most developing countries. This study investigated the mechanism involved in CAP-induced reproductive toxicity as well as the effects of its co-administ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00561.x
更新日期：2010-09-01 00:00:00
abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2008.00292.x
更新日期：2008-12-01 00:00:00
abstract：:Preliminary studies have found that the epigallocatechin gallate (EGCG) at proper concentration could promote development of pre-implantation mouse embryos in vitro. However, the underlying mechanisms have not been well understood. In this study, we collected 1-cell embryos from Kunming (KM) mice, cultured them in M16...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12252
更新日期：2014-11-01 00:00:00
abstract：:The biological pigment melanin is present in most of the biological systems. It manifests a host of biological and pharmacological properties. Its role as a molecule with special properties and functions affecting general health, including photoprotective and immunological action, are well recognized. Its antioxidant,...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12748
更新日期：2017-06-01 00:00:00
abstract：:The relationship between haem biosynthesis and intestinal iron absorption in mice was investigated by ascertaining the effect of the haem synthesis inhibitor, griseofulvin, on duodenal iron absorption using both in vivo and in vitro measurements. Urinary 5-aminolaevulinic acid levels were increased within 24 hr of fee...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2004.pto940402.x
更新日期：2004-04-01 00:00:00
abstract：:The development of medium to high-throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption an...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2005.pto960304.x
更新日期：2005-03-01 00:00:00
abstract：:Despite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significan...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.13311
更新日期：2020-06-01 00:00:00
abstract：:This MiniReview is focused on the nature of intercellular signalling along the endothelium that helps to co-ordinate blood flow control in vascular resistance networks. Vasodilation initiated by contracting skeletal muscle ascends from arterioles within the tissue to encompass resistance arteries upstream and thereby ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2011.00798.x
更新日期：2012-01-01 00:00:00
abstract：:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is gene...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2006.pto_232.x
更新日期：2006-03-01 00:00:00
abstract：:Certain chemotherapeutic agents subject cells to oxidative stress, thereby promoting adverse effects. However, the molecular machinery governing 5-fluorouracil (5-FU)-mediated myelotoxicity is obscure. The purpose of this study was to clarify whether 5-FU-induced myelotoxicity is a cause of oxidative stress. Treatment...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00621.x
更新日期：2011-01-01 00:00:00
abstract：:In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspecti...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12946
更新日期：2018-05-01 00:00:00
abstract：:The introduction of new COX-2 inhibitors with high efficacy and enhanced safety profile would be a great achievement in the development of anti-inflammatory drugs. This study was designed to screen and assess the anti-inflammatory and analgesic activities as well as some of the expected side effects of some pyrazole d...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00648.x
更新日期：2011-04-01 00:00:00
abstract：:Ethylene glycol classically produces an elevated anion gap metabolic acidosis. We report a series of patients with ethylene glycol toxicity with a component of non-anion gap metabolic acidosis without known associated confounding factors. A retrospective review of Poison Control Center records were searched more than ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2008.00334.x
更新日期：2009-01-01 00:00:00
abstract：:This report presents the results of two treatment cross-over investigations on 20 healthy male volunteers to assess the bioequivalence of two suppository products of diclofenac sodium. The study was carried out under US Food and Drug Administration Guidelines. The two products were voltaren (100 mg) suppository (Ciba-...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章
doi：10.1111/j.1742-7843.2004.t01-1-pto950503.x
更新日期：2004-12-01 00:00:00
abstract：:Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity to different tumour cell lines. α-Eudesmol showed IC₅₀ values ranging from 5.38 ± 1.10 to 10.60 ± 1.33 μg/mL for B16-F10 and K562 cell lines, β-eudesmol showed I...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12097
更新日期：2013-11-01 00:00:00
