A two-way cross-over bioequivalence study comparing two products of diclofenac sodium suppositories in healthy human volunteers.

abstract：:Whilst mitotic rat embryonic cardiomyoblast-derived H9c2 cells have been widely used as a model system to study the protective mechanisms associated with flavonoids, they are not fully differentiated cardiac cells. Hence, the aim of this study was to investigate the cardioprotective and cardiotoxic actions of querceti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Daubney J,Bonner PL,Hargreaves AJ,Dickenson JM

更新日期：2015-02-01 00:00:00

abstract：:We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these p...

journal_title：Basic & clinical pharmacology & toxicology

authors： Alizadeh AM,Hassanian-Moghaddam H,Shadnia S,Zamani N,Mehrpour O

更新日期：2014-09-01 00:00:00

abstract：:One of the most common risks after a heart transplant is bleeding. In this study, the effect of desmopressin administration on the amount of bleeding and transfusion requirements after heart transplant surgery was investigated. In a double-blind clinical trial, 48 patients who were candidates for heart transplant surg...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jahangirifard A,Razavi MR,Ahmadi ZH,Forozeshfard M

更新日期：2017-09-01 00:00:00

abstract：:This work demonstrates how full modelling power in statistically mixed models can be used to study generalizability (reliability) coefficients of advanced data from human experimental pain studies utilizing placebo data from drug screening trials. This can be used to help optimizing outcome parameters from existing da...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pryseley A,Ledent EY,Drewes AM,Staahl C,Olesen AE,Arendt-Nielsen L

更新日期：2009-08-01 00:00:00

abstract：:Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample c...

journal_title：Basic & clinical pharmacology & toxicology

authors： Neuvonen M,Tarkiainen EK,Tornio A,Hirvensalo P,Tapaninen T,Paile-Hyvärinen M,Itkonen MK,Holmberg MT,Kärjä V,Männistö VT,Neuvonen PJ,Pihlajamäki J,Backman JT,Niemi M

更新日期：2018-03-01 00:00:00

abstract：:Latex allergy is important due to serious health impacts and widespread use of its products. Latex allergic reactions can be induced in skin and mucosal surfaces including the respiratory tract. The development of murine models of allergic airway inflammation has provided a framework to dissect out the cellular and mo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farzaneh P,Hassan ZM,Pourpak Z,Hoseini AZ,Hogan SP

更新日期：2006-12-01 00:00:00

abstract：:In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang Y,Zhang H,Yang Z,Miao D,Zhang D

更新日期：2018-02-01 00:00:00

abstract：:In previous studies we have reported that NQ301, a synthetic 1,4-naphthoquinone derivative, displays a potent antithrombotic activity, and that this might be due to antiplatelet effect, which was mediated by the inhibition of cytosolic Ca(2+) mobilization in activated platelets. In the present study, the effect of NQ3...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Cho MR,Lee KS,Lee JJ,Lim Y,Han XH,Oh KW,Hong JT,Yoo HS,Yun YP

更新日期：2005-09-01 00:00:00

abstract：:The constitutive endothelial nitric oxide synthase (eNOS) plays a major role in circulatory homoeostasis and shows genetic polymorphism. eNOS is expressed and functional in blood cells, including erythrocytes. There is limited knowledge about the consequences of eNOS genetic variability in haemorheological parameters ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Babaoglu MO,Dikmenoglu N,Ileri-Gurel E,Seringec N,Zoto T,Yasar U,Kayaalp SO,Bozkurt A

更新日期：2011-03-01 00:00:00

abstract：:Fluorochemicals are a diverse group of synthetically produced compounds with the unique ability to repel water as well as oil. This property makes them ideal for multiple purposes in a variety of consumer and industrial products. Fluorochemicals have been detected in the environment, as well as in human blood, urine a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Taxvig C,Rosenmai AK,Vinggaard AM

更新日期：2014-07-01 00:00:00

abstract：:Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P,Abdennebi-Najar L,Barouki R,Cranor CF,Etzel RA,Gee D,Heindel JJ,Hougaard KS,Hunt P,Nawrot TS,Prins GS,Ritz B,Soffritti M,Sunyer J,Weihe P

更新日期：2019-08-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) and MSC-derived small extracellular vesicles (sEVs) are promising candidates for cell-based and cell-free regenerative medicine, respectively. By virtue of their multiple lineage differentiation capacity, MSCs have been implicated as an ideal tool for bone and cartilage regeneration. Howe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang X,Thomsen P

更新日期：2021-01-01 00:00:00

abstract：:There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mukherjee S,Saha N

更新日期：2018-03-01 00:00:00

abstract：:Large-conductance Ca(2+) -activated K(+) channels (BKC a ), located on the vascular smooth muscle, play an important role in regulation of vascular tone. In penile corpus cavernosum tissue, opening of BKC a channels leads to relaxation of corporal smooth muscle, which is essential during erection; however, there is li...

journal_title：Basic & clinical pharmacology & toxicology

authors： Király I,Pataricza J,Bajory Z,Simonsen U,Varro A,Papp JG,Pajor L,Kun A

更新日期：2013-07-01 00:00:00

abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Möller J,Laflamme L,Söderberg Löfdal K

更新日期：2015-02-01 00:00:00

abstract：:The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mogensen S,Sverrisdóttir E,Sveinsdóttir K,Treldal C,Jensen K,Jensen AB,Kristensen CA,Jacobsen J,Kreilgaard M,Petersen J,Andersen O

更新日期：2017-01-01 00:00:00

abstract：:The retinal fundus offers a rare opportunity to visualize the microcirculation in man using minimally invasive approaches. The purpose of this MiniReview is to summarize recent work on genetic and early life influences on the retinal microcirculation and to suggest how these observations may help inform our understand...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hughes AD

更新日期：2012-01-01 00:00:00

abstract：:Is it not more comfortable to spit saliva in a tube than to be pricked with a needle to draw blood to analyse your health and disease risk? Many patients, study participants and (parents of) young children undoubtedly prefer non-invasive and convenient procedures. Such procedures increase compliance rates especially f...

journal_title：Basic & clinical pharmacology & toxicology

authors： Langie SAS,Moisse M,Declerck K,Koppen G,Godderis L,Vanden Berghe W,Drury S,De Boever P

更新日期：2017-09-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:At the time that Paracelsus coined his famous dictum, 'What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison', embryonic toxicology was a fairly focused discipline that mainly dealt with occupational poisonings and side effects of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P

更新日期：2016-08-01 00:00:00

abstract：:Preliminary studies have found that the epigallocatechin gallate (EGCG) at proper concentration could promote development of pre-implantation mouse embryos in vitro. However, the underlying mechanisms have not been well understood. In this study, we collected 1-cell embryos from Kunming (KM) mice, cultured them in M16...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang W,Lv J,Zhang Y,Jiang Y,Chu C,Wang S

更新日期：2014-11-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from the heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-do...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Veggel M,Van der Veen G,Jansen T,Westerman E

更新日期：2017-11-01 00:00:00

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00

abstract：:Extrasynaptic δ subunit-containing γ-aminobutyric acid type A receptors (δ-GABAA Rs) are emerging as targets for a number of neuropsychopharmacological drugs, including the direct GABA site agonist gaboxadol and neuroactive steroids. Among other regions, these δ-GABAA Rs are functionally expressed in the ventral tegme...

journal_title：Basic & clinical pharmacology & toxicology

authors： Siivonen MS,de Miguel E,Aaltio J,Manner AK,Vahermo M,Yli-Kauhaluoma J,Linden AM,Aitta-Aho T,Korpi ER

更新日期：2018-11-01 00:00:00

abstract：:The development of medium to high-throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption an...

journal_title：Basic & clinical pharmacology & toxicology

authors： van de Waterbeemd H

更新日期：2005-03-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Rapamycin is a macrocyclic lactone currently used for the treatment of cancer and for the prevention of transplant rejection. The primary pharmacological mode of action of rapamycin occurs through the inhibition (blocking) of the mammalian target of rapamycin (mTOR). By doing so, rapamycin interferes with the phosphoi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fagone P,Donia M,Mangano K,Quattrocchi C,Mammana S,Coco M,Libra M,McCubrey JA,Nicoletti F

更新日期：2013-01-01 00:00:00

abstract：:Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. Although such drugs, especially ranitidine and famotidine, are still widely used, their effects on semen quality, and hence on male infertility, is still u...

journal_title：Basic & clinical pharmacology & toxicology

authors： Banihani SA

更新日期：2016-01-01 00:00:00