Genetic and early life influences on the human retinal microcirculation.

abstract：:Gastric carcinoma (GC) is a pernicious neoplasm with high morbidity and mortality. Sinomenine (SIN) has long been exploited to heal rheumatoid arthritis. Recently, SIN has been discovered to exert the antitumour functions in diverse cancers. However, the impacts of SIN on GC remain indistinct. We attempted to expose t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yuan H,Zhang J,Li F,Li W,Wang H

更新日期：2019-11-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:Vanishing bile duct syndrome is a severe cholestatic disease associated with toxic effects of medications. Stevens-Johnson syndrome is a hypersensitivity disorder that may also be caused by medications. We present a case of a 62-year-old male patient who developed vanishing bile duct syndrome a month after Stevens-Joh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Juricic D,Hrstic I,Radic D,Skegro M,Coric M,Vucelic B,Francetic I

更新日期：2010-01-01 00:00:00

abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2008-05-01 00:00:00

abstract：:Preliminary studies have found that the epigallocatechin gallate (EGCG) at proper concentration could promote development of pre-implantation mouse embryos in vitro. However, the underlying mechanisms have not been well understood. In this study, we collected 1-cell embryos from Kunming (KM) mice, cultured them in M16...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang W,Lv J,Zhang Y,Jiang Y,Chu C,Wang S

更新日期：2014-11-01 00:00:00

abstract：:Previous studies suggest that flavonol icariin protects against neuron injury after oxygen and glucose deprivation by increasing SIRT1. This study demonstrates that icariin can inhibit H(2) O(2) -induced neurotoxicity. The neuroprotection of icariin enhances the antioxidant capacity through both a direct scavenging ef...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang L,Huang S,Chen Y,Wang Z,Li E,Xu Y

更新日期：2010-11-01 00:00:00

abstract：:Curcumin is the effective ingredient of turmeric, sometimes used as a painkiller in traditional medicine. It has extensive biological properties such as anti-inflammatory and antioxidant activities. SARS-CoV-2 is a betacoronavirus developing severe pneumonitis. Inflammasome is one of the most important components of i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saeedi-Boroujeni A,Mahmoudian-Sani MR,Bahadoram M,Alghasi A

更新日期：2021-01-01 00:00:00

abstract：:The cannabinoid 1 receptor antagonist AM 251 is known to block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. We examined the ability of AM 251 to inhibit sodium channel-dependent functions and the ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liao C,Zheng J,David LS,Nicholson RA

更新日期：2004-02-01 00:00:00

abstract：:Juglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, juglone has been shown to counteract apoptosis, for example, of neurons. In an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Calabrò S,Alzoubi K,Bissinger R,Jilani K,Faggio C,Lang F

更新日期：2015-06-01 00:00:00

abstract：:We investigated the effects of (1,4)-alpha-D-glucan (alpha-DG), a novel immune stimulatory drug from Tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [IL]-1beta, IL-6, tumour necrosis factor-alpha [TNF-alpha], gamma-interferon [IFN-gamma] and IL-10) in the lung and spleen...

journal_title：Basic & clinical pharmacology & toxicology

authors： Velazquez EA,Kimura D,Torbati D,Ramachandran C,Totapally BR

更新日期：2009-11-01 00:00:00

abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...

journal_title：Basic & clinical pharmacology & toxicology

authors： Raaska K,Raitasuo V,Laitila J,Neuvonen PJ

更新日期：2004-01-01 00:00:00

abstract：:The biological pigment melanin is present in most of the biological systems. It manifests a host of biological and pharmacological properties. Its role as a molecule with special properties and functions affecting general health, including photoprotective and immunological action, are well recognized. Its antioxidant,...

journal_title：Basic & clinical pharmacology & toxicology

authors： ElObeid AS,Kamal-Eldin A,Abdelhalim MAK,Haseeb AM

更新日期：2017-06-01 00:00:00

abstract：:Naringin, an active flavonoid isolated from citrus fruit extracts, exhibits biological and pharmacological properties, such as antioxidant activity and antidiabetic effect. Mitogen-activated protein kinase (MAPK) signalling pathway has been shown to participate in hyperglycaemia-induced injury. The present study teste...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen J,Guo R,Yan H,Tian L,You Q,Li S,Huang R,Wu K

更新日期：2014-04-01 00:00:00

abstract：:Cytochrome P450 2C8 (CYP2C8) plays important roles in the metabolism of various drugs, including the anti-cancer drug, paclitaxel. We recently identified two novel CYP2C8 alleles (CYP2C8*13 and CYP2C8*14; wild-type, CYP2C8*1A) with non-synonymous single nucleotide polymorphisms in a Japanese population. To precisely i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanioka N,Matsumoto K,Saito Y,Narimatsu S

更新日期：2010-07-01 00:00:00

abstract：:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is gene...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bate A,Edwards IR

更新日期：2006-03-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used to treat acute pro-myelocytic leukaemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cellular membrane. Consistent with these findings, in this study...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao X,Shi YQ,Yan CC,Feng PF,Wang X,Zhang R,Zhang X,Li BX

更新日期：2015-06-01 00:00:00

abstract：:Alzheimer's disease is a neurodegenerative disorder that is characterized by the accumulation of senile plaques containing amyloid β (Aβ) and neurofibrillary tangles composed of hyperphosphorylated tau protein in the brain. Oxidative stress has been proposed to mediate Aβ-induced neurotoxicity. In that regard, we eval...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mohammadi M,Yazdanparast R

更新日期：2011-06-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pereira P,de Oliveira PA,Ardenghi P,Rotta L,Henriques JA,Picada JN

更新日期：2006-11-01 00:00:00

abstract：:δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the rec...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk-Petersen CB,Søgaard R,Madsen KL,Klein AB,Frølund B,Wellendorph P

更新日期：2017-08-01 00:00:00

abstract：:Angiotensin-converting enzyme (ACE) plays an important role in the physiological control of blood pressure and inflammation. Insertion/deletion (I/D) polymorphism of the gene for ACE was investigated in relation to cardiovascular, cerebrovascular, neurodegenerative and inflammatory diseases. The purpose of the present...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nacak M,Erbagci Z,Buyukafsar K,Yurtsever AS,Tiftik RN

更新日期：2007-08-01 00:00:00

abstract：:Doxorubicin is an important and effective anticancer drug widely used for the treatment of various types of cancer but its clinical use is limited by dose-dependent cardiotoxicity. Elevated tissue levels of cellular superoxide anion/oxidative stress are a mechanism by which doxorubicin-induced cardiotoxicity. Selected...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wattanapitayakul SK,Chularojmontri L,Herunsalee A,Charuchongkolwongse S,Niumsakul S,Bauer JA

更新日期：2005-01-01 00:00:00

abstract：:Hematide is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented inclu...

journal_title：Basic & clinical pharmacology & toxicology

authors： Woodburn KW,Wilson SD,Fong KL,Schatz PJ,Spainhour CB,Norton D

更新日期：2009-02-01 00:00:00

abstract：:Fluorochemicals are a diverse group of synthetically produced compounds with the unique ability to repel water as well as oil. This property makes them ideal for multiple purposes in a variety of consumer and industrial products. Fluorochemicals have been detected in the environment, as well as in human blood, urine a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Taxvig C,Rosenmai AK,Vinggaard AM

更新日期：2014-07-01 00:00:00

abstract：:Our objective was to identify the cytochrome P450 (CYP) enzymes that metabolise pioglitazone and to examine the effects of the CYP2C8 inhibitors montelukast, zafirlukast, trimethoprim and gemfibrozil on pioglitazone metabolism in vitro. The effect of different CYP isoform inhibitors on the elimination of a clinically ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jaakkola T,Laitila J,Neuvonen PJ,Backman JT

更新日期：2006-07-01 00:00:00

abstract：:Angiogenic therapy is one of the new treatments of ischaemic heart disease. Oestrogen has angiogenic properties under hypoxic condition, and if oestrogen also induces angiogenesis under normoxic condition, it could be used in combination with other angiogenic therapies in the treatment of ischaemic heart disease. In t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nematbakhsh M,Ghadesi M,Hosseinbalam M,Khazaei M,Gharagozloo M,Dashti G,Rajabi P,Rafieian S

更新日期：2008-09-01 00:00:00

abstract：:The potent neurotoxin saxitoxin (STX) belongs to a group of structurally related analogues produced by both marine and freshwater phytoplankton. The toxins act by blocking voltage-gated sodium channels stopping the inflow of sodium ions and the generation of action potentials. Exposure from marine sources occurs as a ...

journal_title：Basic & clinical pharmacology & toxicology

authors： O'Neill K,Musgrave IF,Humpage A

更新日期：2017-04-01 00:00:00

abstract：:In recent years, several online tools have appeared capable of identifying potential plagiarism in science. While such tools may help to maintain or even increase the originality and ethical quality of the scientific literature, no apparent consensus exists among editors on the degree of plagiarism or self-plagiarism ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lykkesfeldt J

更新日期：2016-08-01 00:00:00

abstract：:Most steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conversion to steroid ho...

journal_title：Basic & clinical pharmacology & toxicology

authors： Krysiak R,Okopien B

更新日期：2014-04-01 00:00:00

abstract：:Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of generalized vitiligo. Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that ca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lan WJ,Wang HY,Lan W,Wang KY

更新日期：2008-07-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00