Polyfluorinated alkyl phosphate ester surfactants - current knowledge and knowledge gaps.

abstract：:The introduction of new COX-2 inhibitors with high efficacy and enhanced safety profile would be a great achievement in the development of anti-inflammatory drugs. This study was designed to screen and assess the anti-inflammatory and analgesic activities as well as some of the expected side effects of some pyrazole d...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mohy El-Din MM,Senbel AM,Bistawroos AA,El-Mallah A,Nour El-Din NA,Bekhit AA,Abd El Razik HA

更新日期：2011-04-01 00:00:00

abstract：:High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Cap...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen L,Xiong X,Hou X,Wei H,Zhai J,Xia T,Gong X,Gao S,Feng G,Tao X,Zhang F,Chen W

更新日期：2019-08-01 00:00:00

abstract：:Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord. The aim of the present study was to ascertain whether this pattern of COX-2 and COX-1 expression applies also to other pain conditions induced by surgical proc...

journal_title：Basic & clinical pharmacology & toxicology

authors： Prochazkova M,Dolezal T,Sliva J,Krsiak M

更新日期：2006-08-01 00:00:00

abstract：:The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) involved the Food and Drug Administration, the National Toxicology Program and 14 academic investigators funded by the National Institute of Environmental Health Sciences. Two key questions to be answered by CLARITY-BPA were as follo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vom Saal FS

更新日期：2019-08-01 00:00:00

abstract：:Endotoxin-induced sepsis in pigs is a recognized experimental model for the study of human septic shock. Generally, pigs are brought into general anaesthesia before sepsis is induced. It is our experience that drug dosages of propofol and fentanyl need to be reduced during endotoxin-induced sepsis, in order to prevent...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bollen PJ,Nielsen BJ,Toft P

更新日期：2007-09-01 00:00:00

abstract：:Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous disease with high mortality. Dithiocarbamates (DTC) are organosulphur compounds widely used in agriculture, industry and households. We report a case of TEN after exposure to mancozeb in fungicide. A 48-year-old 75 kg b.w. man was admitted with fever...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zakharov S,Csomor J,Urbanek P,Pelclova D

更新日期：2016-01-01 00:00:00

abstract：:The use of herbal or natural medicines for the treatment of various disorders has a long and extensive history. Many of these herbal medicines are finding their way onto the world market as alternatives to prescribed drugs currently available to treat various disorders/ailments. In particular, hyperlipidaemia is a maj...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang TH,Kota BP,Razmovski V,Roufogalis BD

更新日期：2005-01-01 00:00:00

abstract：:Vitamin K antagonists (VKA) are highly effective anticoagulants but their use is hampered by multiple interactions with food and medicine and a narrow therapeutic range. The large variation in dose requirements has led to the development of several dosing algorithms based on pharmacogenetic and clinical variables. In ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Skov J,Bladbjerg EM,Rasmussen MA,Sidelmann JJ,Leppin A,Jespersen J

更新日期：2012-02-01 00:00:00

abstract：:DOV 216,303, an inhibitor of serotonin, noradrenaline and dopamine reuptake, belongs to a new line of drugs called 'triple reuptake inhibitors' that have been proposed for treatment of depression. The addictive drug cocaine has similar mechanism of action and exerts rewarding effects by blocking reuptake of dopamine, ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sørensen G,Husum H,Brennum LT,Bundgaard C,Montezinho LC,Mørk A,Wörtwein G,Woldbye DP

更新日期：2014-06-01 00:00:00

abstract：:Whilst mitotic rat embryonic cardiomyoblast-derived H9c2 cells have been widely used as a model system to study the protective mechanisms associated with flavonoids, they are not fully differentiated cardiac cells. Hence, the aim of this study was to investigate the cardioprotective and cardiotoxic actions of querceti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Daubney J,Bonner PL,Hargreaves AJ,Dickenson JM

更新日期：2015-02-01 00:00:00

abstract：:P-glycoprotein (P-gp), an important efflux transporter in intestine, regulates the bioavailability of orally taken drugs. To develop an in vitro model that preferably mimics the physiological microenvironment of human intestine, we employed the three-dimensionally (3D) cultured organoids from human normal small intest...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao J,Zeng Z,Sun J,Zhang Y,Li D,Zhang X,Liu M,Wang X

更新日期：2017-03-01 00:00:00

abstract：:There is an obvious urgent need to find effective and safe therapies to prevent both recurrence and progression of bladder cancer. In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-ka...

journal_title：Basic & clinical pharmacology & toxicology

authors： Li J,Cheng Y,Qu W,Sun Y,Wang Z,Wang H,Tian B

更新日期：2011-02-01 00:00:00

abstract：BACKGROUND:It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate whether the effectiveness ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Møller Gundersen K,Nygaard Jensen J,Bjerrum L,Hansen MP

更新日期：2019-05-01 00:00:00

abstract：:At the time that Paracelsus coined his famous dictum, 'What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison', embryonic toxicology was a fairly focused discipline that mainly dealt with occupational poisonings and side effects of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P

更新日期：2016-08-01 00:00:00

abstract：:Copper deficiency had been suggested to link between fructose-enriched diet (FED) and the development of non-alcoholic fatty liver disease (NAFLD). In this study, we characterized changes in hepatic copper concentrations and hepatic oxidative milieu, in rats with the metabolic syndrome and NAFLD as a result of FED wit...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ackerman Z,Skarzinski G,Grozovski M,Oron-Herman M,Sela BA

更新日期：2014-12-01 00:00:00

abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...

journal_title：Basic & clinical pharmacology & toxicology

authors： Raaska K,Raitasuo V,Laitila J,Neuvonen PJ

更新日期：2004-01-01 00:00:00

abstract：:Lornoxicam is extensively metabolized by CYP2C9, and a CYP2C9*13 is one of the principal variant alleles in East Asian populations. The aim of this study was to evaluate the effects of CYP2C9*1/*13 on the pharmacokinetic parameters of lornoxicam in healthy individuals. A single oral dose of 8 mg lornoxicam was given t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Choi CI,Kim MJ,Jang CG,Park YS,Bae JW,Lee SY

更新日期：2011-12-01 00:00:00

abstract：:Several investigations demonstrate that neurotoxins isolated from venoms of spiders and wasps may exert specific and selective activity on structures of the mammalian CNS. In the present work we examine the neurological effects of the low molecular weight compounds of the denatured venom of the neotropical social wasp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mortari MR,Cunha AO,de Oliveira L,Vieira EB,Gelfuso EA,Coutinho-Netto J,Ferreira dos Santos W

更新日期：2005-11-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:Maximizing the likelihood of success in Phase III is the ultimate goal of the use of modelling and simulation in the drug development process. The success in Phase III depends primarily on two questions: 1) Is the drug regimen actually efficacious and safe in the targeted patient population?, and 2) Will the planned P...

journal_title：Basic & clinical pharmacology & toxicology

authors： De Ridder F

更新日期：2005-03-01 00:00:00

abstract：:Most steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conversion to steroid ho...

journal_title：Basic & clinical pharmacology & toxicology

authors： Krysiak R,Okopien B

更新日期：2014-04-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:Our previous studies with the use of non-selective cyclooxygenase (COX) inhibitor, indomethacin, demonstrated that prostanoids produced during endotoxaemia increase inducible nitric oxide synthase (iNOS) protein expression and nitric oxide synthesis, and decrease cyctochrome P450 (CYP) 4A1 protein expression and CYP 4...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tunctan B,Korkmaz B,Cuez T,Kemal Buharalioglu C,Sahan-Firat S,Falck J,Malik KU

更新日期：2010-11-01 00:00:00

abstract：:QF-036 is an HIV-1 maturation inhibitor in pre-clinical development, and its antiviral activity against a laboratory HIV-1 strain and two drug-resistant strains was determined in the C8166 line. QF-036 was also subjected to absorption, distribution and metabolism (ADM) assessment in vitro, and pharmacokinetic profiles...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao L,He HH,Ou-Yang T,Liu DF,Jiang CH,Yang HP,Wang P,Xie N,Yan SS

更新日期：2021-02-01 00:00:00

abstract：:Opioids alter resting state brain oscillations by multiple and complex factors, which are still to be elucidated. To increase our knowledge, multi-channel electroencephalography (EEG) was subjected to multivariate pattern analysis (MVPA), to identify the most descriptive frequency bands and scalp locations altered by ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Graversen C,Malver LP,Kurita GP,Staahl C,Christrup LL,Sjøgren P,Drewes AM

更新日期：2015-05-01 00:00:00

abstract：:The development of medium to high-throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption an...

journal_title：Basic & clinical pharmacology & toxicology

authors： van de Waterbeemd H

更新日期：2005-03-01 00:00:00

abstract：:In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predict...

journal_title：Basic & clinical pharmacology & toxicology

authors： Petersen TK

更新日期：2006-08-01 00:00:00

abstract：:The relationship between haem biosynthesis and intestinal iron absorption in mice was investigated by ascertaining the effect of the haem synthesis inhibitor, griseofulvin, on duodenal iron absorption using both in vivo and in vitro measurements. Urinary 5-aminolaevulinic acid levels were increased within 24 hr of fee...

journal_title：Basic & clinical pharmacology & toxicology

authors： Laftah AH,Raja KB,Beaumont N,Simpson RJ,Deacon A,Solanky N,Srai SK,Peters TJ

更新日期：2004-04-01 00:00:00

abstract：:We evaluated the effects of conjugated enzyme-nerve agent product resulting from the inhibition of bioscavenger human serum butyrylcholinesterase (Hu BChE) by nerve agents soman or VX. Rats were trained on a multiple Fixed-Ratio 32, Extinction 30 sec. (FR32, Ext30) schedule of food reinforcement and then injected (i.m...

journal_title：Basic & clinical pharmacology & toxicology

authors： Genovese RF,Sun W,Johnson CC,Ditargiani RC,Doctor BP,Saxena A

更新日期：2010-05-01 00:00:00