Simplified acute physiology score II/acute physiology and chronic health evaluation II and prediction of the mortality and later development of complications in poisoned patients admitted to intensive care unit.

abstract：:The influence of factors acting during the intrauterine period on health outcomes of offspring is of considerable research and public health interest. There are, however, methodological challenges in establishing robust causal links, because exposures often act many decades before outcomes of interest, may act before ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Smith GD

更新日期：2008-02-01 00:00:00

abstract：:Angiogenic therapy is one of the new treatments of ischaemic heart disease. Oestrogen has angiogenic properties under hypoxic condition, and if oestrogen also induces angiogenesis under normoxic condition, it could be used in combination with other angiogenic therapies in the treatment of ischaemic heart disease. In t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nematbakhsh M,Ghadesi M,Hosseinbalam M,Khazaei M,Gharagozloo M,Dashti G,Rajabi P,Rafieian S

更新日期：2008-09-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays a pathogenic role in diabetic nephropathy (DN). Rosmarinic acid (RA) is a naturally occurring phenolic acid. This study was conducted to investigate the efficacy of RA on DN and to elucidate the potential mechanism. High glucose (HG)-stimulated cultured human renal proximal...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jiang WL,Xu Y,Zhang SP,Hou J,Zhu HB

更新日期：2012-04-01 00:00:00

abstract：:Magnolol is a pharmacological biphenolic compound extracted from Chinese herb Magnolia officinalis, which displays anti-inflammatory and antioxidant effects. This study was aimed at exploring the potential effect of magnolol on immune-related liver fibrosis. Herein, BALB/c mice were injected with concanavalin A (ConA,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang H,Ju B,Zhang X,Zhu Y,Nie Y,Xu Y,Lei Q

更新日期：2017-06-01 00:00:00

abstract：:Previous studies suggest that flavonol icariin protects against neuron injury after oxygen and glucose deprivation by increasing SIRT1. This study demonstrates that icariin can inhibit H(2) O(2) -induced neurotoxicity. The neuroprotection of icariin enhances the antioxidant capacity through both a direct scavenging ef...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang L,Huang S,Chen Y,Wang Z,Li E,Xu Y

更新日期：2010-11-01 00:00:00

abstract：:Evidence of poor prescribing is widespread including overuse of medicines, underuse of effective medicines, avoidable adverse drug reactions and medication errors. Junior doctors who have recently graduated are responsible for much of the prescribing that takes place in hospitals and are implicated in many of the adve...

journal_title：Basic & clinical pharmacology & toxicology

authors： Maxwell SR,Cascorbi I,Orme M,Webb DJ,Joint BPS\/EACPT Working Group on Safe Prescribing.

更新日期：2007-12-01 00:00:00

abstract：:In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3A activity in healthy volunteers from Swe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nylén H,Björkhem-Bergman L,Ekström L,Roh HK,Bertilsson L,Eliasson E,Lindh JD,Diczfalusy U

更新日期：2014-10-01 00:00:00

abstract：:Ponesimod, a selective S1P1 receptor modulator, is a potential therapeutic agent for autoimmune disorders. The impact of hepatic or renal impairment on the pharmacokinetics, safety and tolerability of ponesimod and its inactive metabolites, ACT-204426 and ACT-338375, was evaluated. Two separate single-centre, open-lab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guérard N,Zwingelstein C,Hoch M,Dingemanse J

更新日期：2016-05-01 00:00:00

abstract：:The OECD GD 129 BALB/c 3T3 neutral red uptake (NRU) assay is a standardized test method for estimating starting dose for an acute oral systemic toxicity test in rodents. Mouse BALB/c 3T3 fibroblasts are the most commonly used cells in the NRU assay. We have previously transferred and validated BALB/c 3T3 NRU assay in ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mannerström M,Toimela T,Sarkanen JR,Heinonen T

更新日期：2017-09-01 00:00:00

abstract：:Substantial development in the pharmacological treatment for attention-deficit hyperactivity disorder (ADHD) has been made recently including approval of new non-stimulant agents targeting noradrenergic, histaminergic and dopaminergic systems. Among such, atomoxetine has been widely used, although its mechanism of act...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu LL,Yang J,Lei GF,Wang GJ,Wang YW,Sun RP

更新日期：2008-06-01 00:00:00

abstract：:Extrasynaptic δ subunit-containing γ-aminobutyric acid type A receptors (δ-GABAA Rs) are emerging as targets for a number of neuropsychopharmacological drugs, including the direct GABA site agonist gaboxadol and neuroactive steroids. Among other regions, these δ-GABAA Rs are functionally expressed in the ventral tegme...

journal_title：Basic & clinical pharmacology & toxicology

authors： Siivonen MS,de Miguel E,Aaltio J,Manner AK,Vahermo M,Yli-Kauhaluoma J,Linden AM,Aitta-Aho T,Korpi ER

更新日期：2018-11-01 00:00:00

abstract：:Chalcones represent an important group of natural or synthetic compounds with a variety of biological activities including antinociceptive and anti-inflammatory ones. The aim of this work was the synthesis of a new benzofuranone compound and evaluation of its antinociceptive potential in mice. The new benzofuranone 4 ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Padaratz P,Fracasso M,de Campos-Buzzi F,Corrêa R,Niero R,Delle Monache F,Cechinel-Filho V

更新日期：2009-10-01 00:00:00

abstract：:We evaluated the effects of conjugated enzyme-nerve agent product resulting from the inhibition of bioscavenger human serum butyrylcholinesterase (Hu BChE) by nerve agents soman or VX. Rats were trained on a multiple Fixed-Ratio 32, Extinction 30 sec. (FR32, Ext30) schedule of food reinforcement and then injected (i.m...

journal_title：Basic & clinical pharmacology & toxicology

authors： Genovese RF,Sun W,Johnson CC,Ditargiani RC,Doctor BP,Saxena A

更新日期：2010-05-01 00:00:00

abstract：:δ-Containing GABAA receptors are located extrasynaptically and mediate tonic inhibition. Their involvement in brain physiology positions them as interesting drug targets. There is thus a continued interest in establishing reliable recombinant expression systems for δ-containing GABAA receptors. Inconveniently, the rec...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk-Petersen CB,Søgaard R,Madsen KL,Klein AB,Frølund B,Wellendorph P

更新日期：2017-08-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and growth, although the involved molecular mechanisms have not been elucidated. In many cancer cells, high expression of thymidine phosphorylase (TP) and Excision repair cross-complementation 1 (ERCC1) is associated with poor progno...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ko JC,Huang YC,Chen HJ,Tseng SC,Chiu HC,Wo TY,Huang YJ,Weng SH,Chiou RY,Lin YW

更新日期：2013-07-01 00:00:00

abstract：:Gastric carcinoma (GC) is a pernicious neoplasm with high morbidity and mortality. Sinomenine (SIN) has long been exploited to heal rheumatoid arthritis. Recently, SIN has been discovered to exert the antitumour functions in diverse cancers. However, the impacts of SIN on GC remain indistinct. We attempted to expose t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yuan H,Zhang J,Li F,Li W,Wang H

更新日期：2019-11-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used to treat acute pro-myelocytic leukaemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cellular membrane. Consistent with these findings, in this study...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao X,Shi YQ,Yan CC,Feng PF,Wang X,Zhang R,Zhang X,Li BX

更新日期：2015-06-01 00:00:00

abstract：:One major prerequisite for an orally administered drug is the ability to cross the intestinal epithelia from intestinal lumen into the blood circulation. Therefore, the absorption potential of molecules is studied early on during the drug development process. Permeation experiments using cultured cell monolayers are o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen AT,Korjamo T,Mönkkönen J

更新日期：2010-03-01 00:00:00

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00

abstract：:Most steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conversion to steroid ho...

journal_title：Basic & clinical pharmacology & toxicology

authors： Krysiak R,Okopien B

更新日期：2014-04-01 00:00:00

abstract：:Faldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus. In this single-centre, open-label, fixed-sequence, crossover study of 32 healthy adult male and female volunteers, subjects received either a single dose of cyclosporine (CsA) 50 mg (N = 16) or tacrolimus (TAC) 0.5 mg (N = 16), followed...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang F,Voelk C,Trampisch M,Rowland L,Schultz A,Sabo JP

更新日期：2018-07-01 00:00:00

abstract：:There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mukherjee S,Saha N

更新日期：2018-03-01 00:00:00

abstract：:Pharmacokinetic/pharmacodynamic (PK/PD) models can be useful tools in new drug development and also optimal drug therapy in patients. This study was designed to develop a PK/PD model of sitagliptin based on the physiology of incretin. The PK/PD data included information derived from two different studies. Study 1 was ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim BH,Kim SE,Kang D,Lim KS,Kim JR,Jang IJ,Shin SG,Yoon SH,Cho JY,Yu KS

更新日期：2013-08-01 00:00:00

abstract：:Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated with this, we examined the frequencies of 29 SNPs located in candidate genes related to opioid pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Christoffersen DJ,Damkier P,Feddersen S,Möller S,Thomsen JL,Brasch-Andersen C,Brøsen K

更新日期：2016-10-01 00:00:00

abstract：:Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Origanum majorana L., Lamiaceae, is a potent antioxidant. The effect of administration of O. majorana (volatile oil, alcoholic and aqueous extracts) on oral administration of lead acetate in the diet of ...

journal_title：Basic & clinical pharmacology & toxicology

authors： el-Ashmawy IM,el-Nahas AF,Salama OM

更新日期：2005-10-01 00:00:00

abstract：:Naringin, an active flavonoid isolated from citrus fruit extracts, exhibits biological and pharmacological properties, such as antioxidant activity and antidiabetic effect. Mitogen-activated protein kinase (MAPK) signalling pathway has been shown to participate in hyperglycaemia-induced injury. The present study teste...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen J,Guo R,Yan H,Tian L,You Q,Li S,Huang R,Wu K

更新日期：2014-04-01 00:00:00

abstract：:Genetically engineered mice that either over-express a foreign gene (transgenic) or in which the activity of a specific gene has been removed ("knock-out") or replaced ("knock-in") will be used increasingly to investigate molecular mechanisms of disease, to evaluate innovative therapeutic targets, and to screen novel ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bolon B

更新日期：2004-10-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) is considered as the limiting enzyme of thiopurine metabolism for the formation of 6-thioguanine nucleotides (6-TGN). No data are available on the influence of RBC IMPDH activity on the metabolism of thiopurine drugs in individuals with IBD. The aims of this study were as fo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Citterio-Quentin A,El Mahmoudi A,Perret T,Conway A,Ryan A,Beringer A,Lachaux A,Boulieu R

更新日期：2019-05-01 00:00:00

abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...

journal_title：Basic & clinical pharmacology & toxicology

authors： Almeida IF,Fernandes E,Lima JL,Costa PC,Bahia MF

更新日期：2009-10-01 00:00:00