The effect of aggressive rosuvastatin treatment on steroid hormone production in men with coronary artery disease.

abstract：:Endotoxin-induced sepsis in pigs is a recognized experimental model for the study of human septic shock. Generally, pigs are brought into general anaesthesia before sepsis is induced. It is our experience that drug dosages of propofol and fentanyl need to be reduced during endotoxin-induced sepsis, in order to prevent...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bollen PJ,Nielsen BJ,Toft P

更新日期：2007-09-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00

abstract：:In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3A activity in healthy volunteers from Swe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nylén H,Björkhem-Bergman L,Ekström L,Roh HK,Bertilsson L,Eliasson E,Lindh JD,Diczfalusy U

更新日期：2014-10-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:Imbalanced matrix metalloproteinase (MMP) expression, including MMP-2, has been demonstrated in pre-eclampsia. However, little is known about the effect of polymorphisms in MMP-2 gene on hypertensive disorders of pregnancy. We examined whether two functional MMP-2 polymorphisms (g.-1306C>T and g.-735C>T) are associate...

journal_title：Basic & clinical pharmacology & toxicology

authors： Palei AC,Sandrim VC,Amaral LM,Machado JS,Cavalli RC,Lacchini R,Duarte G,Tanus-Santos JE

更新日期：2012-10-01 00:00:00

abstract：:Young mice (2 weeks old) were given topiramate daily for 1 month, and sudomotor function was evaluated utilizing impression mould techniques to determine the number of sweat glands reactive to heat exposure and sweat output per gland on the plantar surface of mice hind-paws. Immunohistochemical quantitation of protein...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tian J,Huang Y,Deng Y,Chen J,Ma L,Chen X,Jiang W,Zhao G,Wang J

更新日期：2007-06-01 00:00:00

abstract：:Copper deficiency had been suggested to link between fructose-enriched diet (FED) and the development of non-alcoholic fatty liver disease (NAFLD). In this study, we characterized changes in hepatic copper concentrations and hepatic oxidative milieu, in rats with the metabolic syndrome and NAFLD as a result of FED wit...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ackerman Z,Skarzinski G,Grozovski M,Oron-Herman M,Sela BA

更新日期：2014-12-01 00:00:00

abstract：:Osteoarthritis (OA) and the non-steroidal anti-inflammatory drugs (NSAIDs) used to relieve OA-associated pain have been linked independently to increased cardiovascular risk. We examined the risk of cardiovascular events associated with NSAID use in patients with OA. We employed linked nationwide administrative regist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Barcella CA,Lamberts M,McGettigan P,Fosbøl EL,Lindhardsen J,Torp-Pedersen C,Gislason GH,Olsen AS

更新日期：2019-05-01 00:00:00

abstract：:Chemokines are chemotactic cytokines whose involvement in nociceptive processing is being increasingly recognized. Based on the previous description of the involvement of CC chemokine receptor type 1 (CCR1) in pathological pain, we have assessed the participation of CCR1 and its endogenous ligands CCL3 and CCL5 in hyp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Llorián-Salvador M,González-Rodríguez S,Lastra A,Fernández-García MT,Hidalgo A,Menéndez L,Baamonde A

更新日期：2016-07-01 00:00:00

abstract：:This study investigated the antinociceptive effects of zerumbone in chemical behavioural models of nociception in mice. Zerumbone given through intraperitoneal route (i.p.) produced dose-related antinociception when assessed on acetic acid-induced abdominal writhing test in mice. In addition, the i.p. administration o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Perimal EK,Akhtar MN,Mohamad AS,Khalid MH,Ming OH,Khalid S,Tatt LM,Kamaldin MN,Zakaria ZA,Israf DA,Lajis N,Sulaiman MR

更新日期：2011-03-01 00:00:00

abstract：:Cisplatin and other platinum complexes are important chemotherapeutic agents and useful in the treatment for several cancers such as prostate, ovarian and testis. However, severe side effects including reproductive toxicity of cisplatin and other platinum complex cause limitations in their clinical usage. In this cont...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ciftci O,Beytur A,Cakir O,Gurbuz N,Vardi N

更新日期：2011-11-01 00:00:00

abstract：:Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous disease with high mortality. Dithiocarbamates (DTC) are organosulphur compounds widely used in agriculture, industry and households. We report a case of TEN after exposure to mancozeb in fungicide. A 48-year-old 75 kg b.w. man was admitted with fever...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zakharov S,Csomor J,Urbanek P,Pelclova D

更新日期：2016-01-01 00:00:00

abstract：:Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, health...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saruwatari J,Takashima A,Yoshida K,Soraoka H,Ding TB,Uchiyashiki Y,Tsuda Y,Imamura M,Oniki K,Miyata K,Nakagawa K

更新日期：2014-10-01 00:00:00

abstract：:In cardiovascular and metabolic diseases, small resistance arteries may show the presence of structural alterations. In particular, in essential hypertension, an increased media-to-lumen ratio of subcutaneous small arteries with no change in the total amount of vascular wall tissue (eutrophic remodelling) has already ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rizzoni D,De Ciuceis C,Porteri E,Semeraro F,Rosei EA

更新日期：2012-01-01 00:00:00

abstract：:Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant num...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lucafò M,Di Silvestre A,Romano M,Avian A,Antonelli R,Martelossi S,Naviglio S,Tommasini A,Stocco G,Ventura A,Decorti G,De Iudicibus S

更新日期：2018-01-01 00:00:00

abstract：:This study investigated the impact of prolonged nicotine administration on myocardial susceptibility to ischaemia-reperfusion (I/R) injury in a rat model and determined whether nicotine affects mitochondrial reactive oxygen species (ROS) production and permeability transition in rat hearts. Sprague-Dawley rats were ad...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ramalingam A,Mohd Fauzi N,Budin SB,Zainalabidin S

更新日期：2021-02-01 00:00:00

abstract：:Epidemiological data have shown that methamphetamine (MA) abuse significantly increases the risk of developing pulmonary arterial hypertension (PAH). To investigate whether MA could induce PAH and its possible mechanism, rats were exposed daily to MA for 5 weeks in the absence or presence of fluoxetine. The results sh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu M,Wang Y,Wang HM,Bai Y,Zhang XH,Sun YX,Wang HL

更新日期：2013-02-01 00:00:00

abstract：:One of the most common risks after a heart transplant is bleeding. In this study, the effect of desmopressin administration on the amount of bleeding and transfusion requirements after heart transplant surgery was investigated. In a double-blind clinical trial, 48 patients who were candidates for heart transplant surg...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jahangirifard A,Razavi MR,Ahmadi ZH,Forozeshfard M

更新日期：2017-09-01 00:00:00

abstract：:Maximizing the likelihood of success in Phase III is the ultimate goal of the use of modelling and simulation in the drug development process. The success in Phase III depends primarily on two questions: 1) Is the drug regimen actually efficacious and safe in the targeted patient population?, and 2) Will the planned P...

journal_title：Basic & clinical pharmacology & toxicology

authors： De Ridder F

更新日期：2005-03-01 00:00:00

abstract：:One major prerequisite for an orally administered drug is the ability to cross the intestinal epithelia from intestinal lumen into the blood circulation. Therefore, the absorption potential of molecules is studied early on during the drug development process. Permeation experiments using cultured cell monolayers are o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen AT,Korjamo T,Mönkkönen J

更新日期：2010-03-01 00:00:00

abstract：:Tamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30-100 times higher potency than the parent drug, no previous study has compared the effects produced by tamoxifen and its metab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Montenegro MF,Pessa LR,Gomes VA,Desta Z,Flockhart DA,Tanus-Santos JE

更新日期：2009-05-01 00:00:00

abstract：:Epidemiological and animal studies show that small changes in the developmental environment can induce phenotypic changes affecting an individual's responses to their later environment. These may alter the risk of chronic disease such as metabolic syndrome or cardiovascular disease. Recent research shows that animals ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanson MA,Gluckman PD

更新日期：2008-02-01 00:00:00

abstract：:In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predict...

journal_title：Basic & clinical pharmacology & toxicology

authors： Petersen TK

更新日期：2006-08-01 00:00:00

abstract：:In previous studies we have reported that NQ301, a synthetic 1,4-naphthoquinone derivative, displays a potent antithrombotic activity, and that this might be due to antiplatelet effect, which was mediated by the inhibition of cytosolic Ca(2+) mobilization in activated platelets. In the present study, the effect of NQ3...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Cho MR,Lee KS,Lee JJ,Lim Y,Han XH,Oh KW,Hong JT,Yoo HS,Yun YP

更新日期：2005-09-01 00:00:00

abstract：:Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irino...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jung GR,Kim KJ,Choi CH,Lee TB,Han SI,Han HK,Lim SC

更新日期：2007-10-01 00:00:00

abstract：:Microdialysis is a valuable tool to measure tissue responses. We hypothesized that skeletal muscle metabolism can be modulated by microdialysis applied drugs which alter cytosolic calcium concentration. With approval of the local animal care committee, the hind limbs of sacrificed male Sprague Dawley rats were perfuse...

journal_title：Basic & clinical pharmacology & toxicology

authors： Schuster F,Tas P,Müller R,Roewer N,Anetseder M

更新日期：2006-04-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Cap...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen L,Xiong X,Hou X,Wei H,Zhai J,Xia T,Gong X,Gao S,Feng G,Tao X,Zhang F,Chen W

更新日期：2019-08-01 00:00:00

abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2007-11-01 00:00:00