Effects of Seijo-bofu-to, a traditional Japanese herbal medicine containing furanocoumarin derivatives, on the drug-metabolizing enzyme activities in healthy male volunteers.

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...

journal_title：Basic & clinical pharmacology & toxicology

authors： Damkier P,Lassen D,Christensen MMH,Madsen KG,Hellfritzsch M,Pottegård A

更新日期：2019-01-01 00:00:00

abstract：:The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of Garcinia kola) and curcumin (from the rhizome, Curcuma longa L.) on the di-n-butylphthalate (DBP)-induced testicular damage in rats. Administration of DBP to rats at a dose of 2 g/kg for 9 days signific...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farombi EO,Abarikwu SO,Adedara IA,Oyeyemi MO

更新日期：2007-01-01 00:00:00

abstract：:There is an obvious urgent need to find effective and safe therapies to prevent both recurrence and progression of bladder cancer. In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-ka...

journal_title：Basic & clinical pharmacology & toxicology

authors： Li J,Cheng Y,Qu W,Sun Y,Wang Z,Wang H,Tian B

更新日期：2011-02-01 00:00:00

abstract：:This MiniReview is focused on the nature of intercellular signalling along the endothelium that helps to co-ordinate blood flow control in vascular resistance networks. Vasodilation initiated by contracting skeletal muscle ascends from arterioles within the tissue to encompass resistance arteries upstream and thereby ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Socha MJ,Behringer EJ,Segal SS

更新日期：2012-01-01 00:00:00

abstract：:The present study investigated the improving effect of cucurbitacin B on liver fibrosis induced by concanavalin A in mice and explored its possible mechanism. AST, ALT and TB were detected by kits. ELISA was performed to detect the levels of IL 5, IL 6, IL 13 and TNF-α in serum. Haematoxylin-eosin (HE) staining and Ma...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang L,Ao Q,Zhong Q,Li W,Li W

更新日期：2020-11-01 00:00:00

abstract：:DOV 216,303, an inhibitor of serotonin, noradrenaline and dopamine reuptake, belongs to a new line of drugs called 'triple reuptake inhibitors' that have been proposed for treatment of depression. The addictive drug cocaine has similar mechanism of action and exerts rewarding effects by blocking reuptake of dopamine, ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sørensen G,Husum H,Brennum LT,Bundgaard C,Montezinho LC,Mørk A,Wörtwein G,Woldbye DP

更新日期：2014-06-01 00:00:00

abstract：:The currently recommended first-line treatments of erectile dysfunction (ED), phosphodiesterase type 5 inhibitors (PDE5i), for example sildenafil, are efficacious in many patients with ED of vascular origin, but this therapy is insufficient in approximately 30-40% of men with ED where there is also a neuronal affectio...

journal_title：Basic & clinical pharmacology & toxicology

authors： Simonsen U,Comerma-Steffensen S,Andersson KE

更新日期：2016-10-01 00:00:00

abstract：:Retinal arachidonic acid (ARA) levels in form-deprived eyes decline in guinea pigs. As prostaglandin F2α (PGF2α) is an ARA metabolite and endogenous agonist of prostaglandin F receptor (FP), we have been suggested that down-regulation of PGF2α-FP receptor signalling pathway contributes to myopia onset. To test this hy...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang J,Pan M,Reinach PS,Chen R,Yu L,Zhou F,Zhang S,Qu J,Zhou X

更新日期：2018-09-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. In patients for whom HCC could not be detected early, current treatments show poor tolerance and low efficacy. So, alternative therapies with good efficacy are urgently needed. The aim of this research was to evaluate the selective ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Seydi E,Rasekh HR,Salimi A,Mohsenifar Z,Pourahmad J

更新日期：2016-09-01 00:00:00

abstract：BACKGROUND:Long non-coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) is a novel vital oncogenic lncRNA that is dysregulated in various types of cancers, including glioma. According to TargetScan prediction, miR-432-5p is a target of ZFAS1. Herein, we aimed to determine whether there was a correlation between ZFAS1 a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang G,Han B,Feng T

更新日期：2019-12-01 00:00:00

abstract：:Lornoxicam is extensively metabolized by CYP2C9, and a CYP2C9*13 is one of the principal variant alleles in East Asian populations. The aim of this study was to evaluate the effects of CYP2C9*1/*13 on the pharmacokinetic parameters of lornoxicam in healthy individuals. A single oral dose of 8 mg lornoxicam was given t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Choi CI,Kim MJ,Jang CG,Park YS,Bae JW,Lee SY

更新日期：2011-12-01 00:00:00

abstract：:In cardiovascular and metabolic diseases, small resistance arteries may show the presence of structural alterations. In particular, in essential hypertension, an increased media-to-lumen ratio of subcutaneous small arteries with no change in the total amount of vascular wall tissue (eutrophic remodelling) has already ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rizzoni D,De Ciuceis C,Porteri E,Semeraro F,Rosei EA

更新日期：2012-01-01 00:00:00

abstract：:Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminif...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bjørklund G,Chirumbolo S,Dadar M,Pivina L,Lindh U,Butnariu M,Aaseth J

更新日期：2019-10-01 00:00:00

abstract：:Rapamycin is a macrocyclic lactone currently used for the treatment of cancer and for the prevention of transplant rejection. The primary pharmacological mode of action of rapamycin occurs through the inhibition (blocking) of the mammalian target of rapamycin (mTOR). By doing so, rapamycin interferes with the phosphoi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fagone P,Donia M,Mangano K,Quattrocchi C,Mammana S,Coco M,Libra M,McCubrey JA,Nicoletti F

更新日期：2013-01-01 00:00:00

abstract：:High-dose cyclophosphamide (HD-CTX) treatment often leads to severe nephrotoxicity and neurotoxicity, which are mainly caused by one of its metabolites, chloroacetaldehyde (CAA). However, there are no effective antidotes to prevent these side effects. The objective of this study was to evaluate the effect of Wuzhi Cap...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen L,Xiong X,Hou X,Wei H,Zhai J,Xia T,Gong X,Gao S,Feng G,Tao X,Zhang F,Chen W

更新日期：2019-08-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:Quercetin is a plant flavonoid with several biological activities. This study aimed to describe quercetin effects on contractile and electrophysiological properties of the cardiac muscle as well as on calcium handling. Quercetin elicited positive inotropism that was significantly reduced by propranolol indicating an i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Santos MS,Oliveira ED,Santos-Miranda A,Cruz JS,Gondim ANS,Menezes-Filho JER,Souza DS,Pinho-da-Silva L,Jesus ICG,Roman-Campos D,Guatimosim S,Lara A,Conde-Garcia EA,Vasconcelos CML

更新日期：2017-06-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pereira P,de Oliveira PA,Ardenghi P,Rotta L,Henriques JA,Picada JN

更新日期：2006-11-01 00:00:00

abstract：:Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and growth, although the involved molecular mechanisms have not been elucidated. In many cancer cells, high expression of thymidine phosphorylase (TP) and Excision repair cross-complementation 1 (ERCC1) is associated with poor progno...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ko JC,Huang YC,Chen HJ,Tseng SC,Chiu HC,Wo TY,Huang YJ,Weng SH,Chiou RY,Lin YW

更新日期：2013-07-01 00:00:00

abstract：:The aim was to investigate systemic exposure after administration of a novel bupivacaine lozenge in healthy individuals with normal mucosa and in head and neck cancer (HNC) patients with oral mucositis. A lozenge containing 5, 10, 25 and 50 mg bupivacaine, respectively, was administered as single dose to 10 healthy in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mogensen S,Sverrisdóttir E,Sveinsdóttir K,Treldal C,Jensen K,Jensen AB,Kristensen CA,Jacobsen J,Kreilgaard M,Petersen J,Andersen O

更新日期：2017-01-01 00:00:00

abstract：:Fluorochemicals are a diverse group of synthetically produced compounds with the unique ability to repel water as well as oil. This property makes them ideal for multiple purposes in a variety of consumer and industrial products. Fluorochemicals have been detected in the environment, as well as in human blood, urine a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Taxvig C,Rosenmai AK,Vinggaard AM

更新日期：2014-07-01 00:00:00

abstract：:Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. Although such drugs, especially ranitidine and famotidine, are still widely used, their effects on semen quality, and hence on male infertility, is still u...

journal_title：Basic & clinical pharmacology & toxicology

authors： Banihani SA

更新日期：2016-01-01 00:00:00

abstract：:The post-injection olanzapine delirium/sedation syndrome (PDSS) was observed in a 60-year-old Caucasian, schizophrenic, non-smoker and underweight [body mass index (BMI), 18.2 kg/m(2) ] women after the fourth intramuscular injection of 405 mg olanzapine pamoate. Clinical symptoms of PDSS were similar to those of acute...

journal_title：Basic & clinical pharmacology & toxicology

authors： Łukasik-Głębocka M,Sommerfeld K,Teżyk A,Panieński P,Żaba C,Zielińska-Psuja B

更新日期：2015-09-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is associated with several skeletal alterations, particularly in conditions of poor glycaemic control. Insulin therapy is the major conservative treatment for T1DM; however, the effects of this hormone on bone markers of T1DM rats are limited, and the regulatory mechanisms remain elusiv...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bortolin RH,Freire Neto FP,Arcaro CA,Bezerra JF,da Silva FS,Ururahy MA,Souza KS,Lima VM,Luchessi AD,Lima FP,Lia Fook MV,da Silva BJ,Almeida MD,Abreu BJ,de Rezende LA,de Rezende AA

更新日期：2017-03-01 00:00:00

abstract：:This study investigated the mechanisms by which licochalcone B (LCB) inhibits the adhesion,invasion and metastasis of human malignant bladder cancer T24 cells. Cell viability was evaluated using a sulforhodamine B (SRB) assay. Cell migration and invasion ability were conducted using wound-healing assay and matrigel tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao H,Yuan X,Jiang J,Wang P,Sun X,Wang D,Zheng Q

更新日期：2014-12-01 00:00:00

abstract：:One major prerequisite for an orally administered drug is the ability to cross the intestinal epithelia from intestinal lumen into the blood circulation. Therefore, the absorption potential of molecules is studied early on during the drug development process. Permeation experiments using cultured cell monolayers are o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen AT,Korjamo T,Mönkkönen J

更新日期：2010-03-01 00:00:00

abstract：:Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study with the objective to evaluate the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellfritzsch M,Pottegård A,Pedersen AJ,Burghle A,Mouaanaki F,Hallas J,Grove EL,Damkier P

更新日期：2017-04-01 00:00:00

abstract：:The development of medium to high-throughput in vitro screening of ADME (Absorption, Distribution, Metabolism, Excretion) properties has been the reply to higher demands on drug metabolism scientists to cope with progress in chemistry and biology. Two areas will be discussed here, namely screens for oral absorption an...

journal_title：Basic & clinical pharmacology & toxicology

authors： van de Waterbeemd H

更新日期：2005-03-01 00:00:00

abstract：:Melatonin possesses chronobiotic properties, which affects sleep/wake rhythms. We investigated a 7-day administration of melatonin (0.25, 2.5 and 5 mg/kg body weight) on the activity/rest rhythms of a diurnal animal (the ringdove, Streptopelia risoria), aged 2-3 (young) and 10-12 (old) years, and its possible relation...

journal_title：Basic & clinical pharmacology & toxicology

authors： Paredes SD,Terrón MP,Valero V,Barriga C,Reiter RJ,Rodríguez AB

更新日期：2007-04-01 00:00:00