Abstract:
:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the time spent in the open arms on plus-maze, suggesting an anxiolytic-like effect when used in lower doses without affecting locomotion and exploration on the open field. Furthermore, a protective effect against hydrogen peroxide-induced oxidative damage on brain tissue was observed through the treatment with caffeic acid at 1 and 8 mg/kg. However, in the highest dose, caffeic acid induced DNA damage in brain tissue.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Pereira P,de Oliveira PA,Ardenghi P,Rotta L,Henriques JA,Picada JNdoi
10.1111/j.1742-7843.2006.pto_533.xsubject
Has Abstractpub_date
2006-11-01 00:00:00pages
374-8issue
5eissn
1742-7835issn
1742-7843pii
PTOpto_533journal_volume
99pub_type
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