GSTP1 c.313A>G, XPD c.934G>A, XPF c.2505T>C and CASP9 c.-1339A>G Polymorphisms and Severity of Vomiting in Head and Neck Cancer Patients treated with Cisplatin Chemoradiation.

abstract：:Most steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conversion to steroid ho...

journal_title：Basic & clinical pharmacology & toxicology

authors： Krysiak R,Okopien B

更新日期：2014-04-01 00:00:00

abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Sepsova V,Tumova M,Horova A,Musilek K

更新日期：2015-04-01 00:00:00

abstract：:The OECD GD 129 BALB/c 3T3 neutral red uptake (NRU) assay is a standardized test method for estimating starting dose for an acute oral systemic toxicity test in rodents. Mouse BALB/c 3T3 fibroblasts are the most commonly used cells in the NRU assay. We have previously transferred and validated BALB/c 3T3 NRU assay in ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mannerström M,Toimela T,Sarkanen JR,Heinonen T

更新日期：2017-09-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used to treat acute pro-myelocytic leukaemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cellular membrane. Consistent with these findings, in this study...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao X,Shi YQ,Yan CC,Feng PF,Wang X,Zhang R,Zhang X,Li BX

更新日期：2015-06-01 00:00:00

abstract：:Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinject...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cunha AO,Mortari MR,Liberato JL,dos Santos WF

更新日期：2009-06-01 00:00:00

abstract：:Nicotine-methadone interactions have been studied in human beings and in various experimental settings regarding addiction, reward and pain. Most methadone maintenance treatment patients are smokers, and methadone administration has been shown to increase cigarette smoking. Previous in vitro studies have shown that me...

journal_title：Basic & clinical pharmacology & toxicology

authors： Talka R,Salminen O,Tuominen RK

更新日期：2015-04-01 00:00:00

abstract：:Endotoxin-induced sepsis in pigs is a recognized experimental model for the study of human septic shock. Generally, pigs are brought into general anaesthesia before sepsis is induced. It is our experience that drug dosages of propofol and fentanyl need to be reduced during endotoxin-induced sepsis, in order to prevent...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bollen PJ,Nielsen BJ,Toft P

更新日期：2007-09-01 00:00:00

abstract：:The use of herbal or natural medicines for the treatment of various disorders has a long and extensive history. Many of these herbal medicines are finding their way onto the world market as alternatives to prescribed drugs currently available to treat various disorders/ailments. In particular, hyperlipidaemia is a maj...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang TH,Kota BP,Razmovski V,Roufogalis BD

更新日期：2005-01-01 00:00:00

abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...

journal_title：Basic & clinical pharmacology & toxicology

authors： Faro LR,Alfonso M,Cervantes R,Durán R

更新日期：2009-12-01 00:00:00

abstract：:The scope of the current study was to examine the possible effects of sulphated polysaccharides against cyclosporine A-induced glomerular injury. Nephrotoxicity induced by cyclosporine A continues to be a major problem despite its potent immunosuppressive action. Adult male albino rats of Wistar strain were categorize...

journal_title：Basic & clinical pharmacology & toxicology

authors： Josephine A,Veena CK,Amudha G,Preetha SP,Sundarapandian R,Varalakshmi P

更新日期：2007-07-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kanno S,Uwai K,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Takeshita M,Ohtake T,Kimura K,Ishikawa M

更新日期：2006-01-01 00:00:00

abstract：:The morbidity and mortality of a severe calcium channel blocker intoxication is high due to serious toxic cardiac effects. Its treatment is supported by low-quality evidence from the heterogeneous literature. We describe a case of a severe diltiazem intoxication and critically appraise the efficacy and role of high-do...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Veggel M,Van der Veen G,Jansen T,Westerman E

更新日期：2017-11-01 00:00:00

abstract：:Our objective was to identify the cytochrome P450 (CYP) enzymes that metabolise pioglitazone and to examine the effects of the CYP2C8 inhibitors montelukast, zafirlukast, trimethoprim and gemfibrozil on pioglitazone metabolism in vitro. The effect of different CYP isoform inhibitors on the elimination of a clinically ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jaakkola T,Laitila J,Neuvonen PJ,Backman JT

更新日期：2006-07-01 00:00:00

abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...

journal_title：Basic & clinical pharmacology & toxicology

authors： Damkier P,Lassen D,Christensen MMH,Madsen KG,Hellfritzsch M,Pottegård A

更新日期：2019-01-01 00:00:00

abstract：:Lornoxicam is extensively metabolized by CYP2C9, and a CYP2C9*13 is one of the principal variant alleles in East Asian populations. The aim of this study was to evaluate the effects of CYP2C9*1/*13 on the pharmacokinetic parameters of lornoxicam in healthy individuals. A single oral dose of 8 mg lornoxicam was given t...

journal_title：Basic & clinical pharmacology & toxicology

authors： Choi CI,Kim MJ,Jang CG,Park YS,Bae JW,Lee SY

更新日期：2011-12-01 00:00:00

abstract：:Obesity is an increasing health problem, not only in developed countries but also all over the world. In addition to the focus on food intake and energy expenditure, current studies suggest two other important influences on adult body weight: birth weight and postnatal rate of growth. A common procedure in laboratory ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Coe BL,Kirkpatrick JR,Taylor JA,vom Saal FS

更新日期：2008-02-01 00:00:00

abstract：:Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. H...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim KH,Kum YS,Park YY,Park JH,Kim SJ,Lee WR,Lee KG,Han SM,Park KK

更新日期：2010-07-01 00:00:00

abstract：:In the last decades, a number of new antimuscarinic drugs have been introduced for treatment of the overactive bladder (OAB), defined symptomatically (OAB syndrome) or urodynamically (detrusor overactivity). Recently, three new drug principles have been approved for clinical use, the β3 -adrenoceptor agonist, mirabegr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Andersson KE

更新日期：2016-10-01 00:00:00

abstract：BACKGROUND:It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate whether the effectiveness ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Møller Gundersen K,Nygaard Jensen J,Bjerrum L,Hansen MP

更新日期：2019-05-01 00:00:00

abstract：:This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Stage C,Jürgens G,Guski LS,Thomsen R,Bjerre D,Ferrero-Miliani L,Lyauk YK,Rasmussen HB,Dalhoff K,INDICES Consortium (for members of this consortium-see Supplementum).

更新日期：2017-12-01 00:00:00

abstract：:Many compounds display anticholinergic effects which might give rise to cognitive impairment and even delirium. These side effects are caused by their ability to bind to muscarinic receptors in our brain. Especially with combination of compounds, these serious effects are seen. This phenomenon, known as anticholinergi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vrolijk MF,Opperhuizen A,Jansen EH,Bast A,Haenen GR

更新日期：2015-12-01 00:00:00

abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...

journal_title：Basic & clinical pharmacology & toxicology

authors： Almeida IF,Fernandes E,Lima JL,Costa PC,Bahia MF

更新日期：2009-10-01 00:00:00

abstract：:The cannabinoid 1 receptor antagonist AM 251 is known to block the inhibitory effects of endocannabinoids and synthetic cannabinoid agonists on transmitter release through an action at presynaptic cannabinoid 1 receptors in brain. We examined the ability of AM 251 to inhibit sodium channel-dependent functions and the ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liao C,Zheng J,David LS,Nicholson RA

更新日期：2004-02-01 00:00:00

abstract：:Polyphenols are ubiquitous substances in human diet. Their antioxidative, antiinflammatory and antiviral effects are of interest for human health, and polyphenols such as luteolin are used at high concentrations in food supplements. Luteolin is metabolized to glucuronides, but also to methylated derivatives. For examp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Michels G,Mohamed GA,Weber N,Chovolou Y,Kampkötter A,Wätjen W,Proksch P

更新日期：2006-02-01 00:00:00

abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...

journal_title：Basic & clinical pharmacology & toxicology

authors： Raaska K,Raitasuo V,Laitila J,Neuvonen PJ

更新日期：2004-01-01 00:00:00

abstract：:Inadequate antidote stocking is a global problem in hospitals. Insufficient supplies and delays in the administration of antidotes could lead to death and additional potentially negative clinical consequences. Our objective was to determine the availability of antidotes in hospitals listed on the Saudi Ministry of Hea...

journal_title：Basic & clinical pharmacology & toxicology

authors： AlTamimi A,Malhis NK,Khojah NM,Manea SA,AlTamimi A,AlShammary SA

更新日期：2018-02-01 00:00:00

abstract：:This retrospective study investigated whether the serum albumin (SA) concentration at presentation is associated with mortality and the mechanism underlying the association. This study enrolled 217 patients poisoned with organophosphate (OP). Hypoalbuminemia (albumin <3.5 g/dL) at presentation was identified in 18.4% ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Noh E,Moon JM,Chun BJ,Cho YS,Ryu S,Kim D

更新日期：2020-12-11 00:00:00

abstract：:Whilst mitotic rat embryonic cardiomyoblast-derived H9c2 cells have been widely used as a model system to study the protective mechanisms associated with flavonoids, they are not fully differentiated cardiac cells. Hence, the aim of this study was to investigate the cardioprotective and cardiotoxic actions of querceti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Daubney J,Bonner PL,Hargreaves AJ,Dickenson JM

更新日期：2015-02-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of sodium nitrite (NaNO(2))-induced methemoglobinaemia on plasma ATP (adenosine triphosphate) and corresponding changes of blood-ionized magnesium (iMg(2+)) as well as total magnesium (tMg(2+)) in a time-dependent manner. This study was performed on male Sprague-...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rahman MM,Kim SJ,Kim GB,Hong CU,Lee YU,Kim SZ,Kim JS,Kang HS

更新日期：2009-11-01 00:00:00

abstract：:Copper deficiency had been suggested to link between fructose-enriched diet (FED) and the development of non-alcoholic fatty liver disease (NAFLD). In this study, we characterized changes in hepatic copper concentrations and hepatic oxidative milieu, in rats with the metabolic syndrome and NAFLD as a result of FED wit...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ackerman Z,Skarzinski G,Grozovski M,Oron-Herman M,Sela BA

更新日期：2014-12-01 00:00:00