Comparative effects of pesticides on in vivo dopamine release in freely moving rats.

abstract：:Interest in proteomics as a tool for drug development and a myriad of other applications continues to expand at a rapid rate. Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Elrick MM,Walgren JL,Mitchell MD,Thompson DC

更新日期：2006-05-01 00:00:00

abstract：:This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang S,Tang X,Tian J,Li C,Zhang G,Jiang W,Zhang Z

更新日期：2011-06-01 00:00:00

abstract：:Pain involves responses in which both peripheral and central mechanisms contribute to the generation of pain. Pre-clinical laboratory data have supported that a topical formulation of combined diclofenac and methadone (Diclometh) may alleviate local pain, and potentially, the side effect profile should be low. We hypo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Larsen IM,Drewes AM,Olesen AE

更新日期：2018-08-01 00:00:00

abstract：:The biological pigment melanin is present in most of the biological systems. It manifests a host of biological and pharmacological properties. Its role as a molecule with special properties and functions affecting general health, including photoprotective and immunological action, are well recognized. Its antioxidant,...

journal_title：Basic & clinical pharmacology & toxicology

authors： ElObeid AS,Kamal-Eldin A,Abdelhalim MAK,Haseeb AM

更新日期：2017-06-01 00:00:00

abstract：:We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these p...

journal_title：Basic & clinical pharmacology & toxicology

authors： Alizadeh AM,Hassanian-Moghaddam H,Shadnia S,Zamani N,Mehrpour O

更新日期：2014-09-01 00:00:00

abstract：:Vitamin D metabolism was studied in primary human dermal fibroblasts with focus on drug-mediated gene regulation related to adverse side effects of antiretroviral drugs used in HIV therapy. The fibroblasts expressed mRNA for cytochrome P450 (CYP) enzymes catalysing bioactivating (CYP2R1, CYP27A1 and CYP27B1) and catab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Norlin M,Lundqvist J,Ellfolk M,Hellström Pigg M,Gustafsson J,Wikvall K

更新日期：2017-01-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kanno S,Uwai K,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Takeshita M,Ohtake T,Kimura K,Ishikawa M

更新日期：2006-01-01 00:00:00

abstract：:Latex allergy is important due to serious health impacts and widespread use of its products. Latex allergic reactions can be induced in skin and mucosal surfaces including the respiratory tract. The development of murine models of allergic airway inflammation has provided a framework to dissect out the cellular and mo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farzaneh P,Hassan ZM,Pourpak Z,Hoseini AZ,Hogan SP

更新日期：2006-12-01 00:00:00

abstract：:Previous studies have shown that generation of free radicals is increased following pentylenetetrazol kindling, due to increased cytosolic Ca2+ concentrations. Topiramate, a voltage-gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxici...

journal_title：Basic & clinical pharmacology & toxicology

authors： Armagan A,Kutluhan S,Yilmaz M,Yilmaz N,Bülbül M,Vural H,Soyupek S,Naziroglu M

更新日期：2008-08-01 00:00:00

abstract：:Several investigations demonstrate that neurotoxins isolated from venoms of spiders and wasps may exert specific and selective activity on structures of the mammalian CNS. In the present work we examine the neurological effects of the low molecular weight compounds of the denatured venom of the neotropical social wasp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mortari MR,Cunha AO,de Oliveira L,Vieira EB,Gelfuso EA,Coutinho-Netto J,Ferreira dos Santos W

更新日期：2005-11-01 00:00:00

abstract：:The influence of factors acting during the intrauterine period on health outcomes of offspring is of considerable research and public health interest. There are, however, methodological challenges in establishing robust causal links, because exposures often act many decades before outcomes of interest, may act before ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Smith GD

更新日期：2008-02-01 00:00:00

abstract：:Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinject...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cunha AO,Mortari MR,Liberato JL,dos Santos WF

更新日期：2009-06-01 00:00:00

abstract：:DOV 216,303, an inhibitor of serotonin, noradrenaline and dopamine reuptake, belongs to a new line of drugs called 'triple reuptake inhibitors' that have been proposed for treatment of depression. The addictive drug cocaine has similar mechanism of action and exerts rewarding effects by blocking reuptake of dopamine, ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sørensen G,Husum H,Brennum LT,Bundgaard C,Montezinho LC,Mørk A,Wörtwein G,Woldbye DP

更新日期：2014-06-01 00:00:00

abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

journal_title：Basic & clinical pharmacology & toxicology

authors： Iversen TZ,Andersen MH,Svane IM

更新日期：2015-01-01 00:00:00

abstract：:Connective tissue growth factor (CTGF) plays a pathogenic role in diabetic nephropathy (DN). Rosmarinic acid (RA) is a naturally occurring phenolic acid. This study was conducted to investigate the efficacy of RA on DN and to elucidate the potential mechanism. High glucose (HG)-stimulated cultured human renal proximal...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jiang WL,Xu Y,Zhang SP,Hou J,Zhu HB

更新日期：2012-04-01 00:00:00

abstract：:Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample c...

journal_title：Basic & clinical pharmacology & toxicology

authors： Neuvonen M,Tarkiainen EK,Tornio A,Hirvensalo P,Tapaninen T,Paile-Hyvärinen M,Itkonen MK,Holmberg MT,Kärjä V,Männistö VT,Neuvonen PJ,Pihlajamäki J,Backman JT,Niemi M

更新日期：2018-03-01 00:00:00

abstract：:The constitutive endothelial nitric oxide synthase (eNOS) plays a major role in circulatory homoeostasis and shows genetic polymorphism. eNOS is expressed and functional in blood cells, including erythrocytes. There is limited knowledge about the consequences of eNOS genetic variability in haemorheological parameters ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Babaoglu MO,Dikmenoglu N,Ileri-Gurel E,Seringec N,Zoto T,Yasar U,Kayaalp SO,Bozkurt A

更新日期：2011-03-01 00:00:00

abstract：:P-glycoprotein (P-gp), an important efflux transporter in intestine, regulates the bioavailability of orally taken drugs. To develop an in vitro model that preferably mimics the physiological microenvironment of human intestine, we employed the three-dimensionally (3D) cultured organoids from human normal small intest...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao J,Zeng Z,Sun J,Zhang Y,Li D,Zhang X,Liu M,Wang X

更新日期：2017-03-01 00:00:00

abstract：:The aim is to emphasize the importance of extracardiac symptoms of digoxin intoxication in newborns. The most common intoxication symptoms in adults are of cardiac origin, but due to altered symptomatology, digoxin overdose in infants are not always discovered on symptomatic basis. In preterm infants, this is even mor...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nybo M,Damkier P

更新日期：2005-06-01 00:00:00

abstract：:The published data revealed conflicting results of the polymorphism of MDR1 exon 26 SNP C3435T on the pharmacokinetics of cyclosporine; thus, the aim was to conduct a meta-analysis of significant magnitude to investigate the influence of SNP C3435T on the pharmacokinetics of cyclosporine. A literature search was condu...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jiang ZP,Wang YR,Xu P,Liu RR,Zhao XL,Chen FP

更新日期：2008-11-01 00:00:00

abstract：:Methionine-choline-deficient diet represents a model for the study of the pathogenesis of steatohepatitis. Male rats were divided into three groups, the first group receiving a control diet and the other two groups receiving a methionine-choline-deficient diet for 1 month (MCD1) and for 2 months (MCD2), respectively. ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jordao AA,Zanutto ME,Domenici FA,Portari GV,Cecchi AO,Zucoloto S,Vannucchi H

更新日期：2009-09-01 00:00:00

abstract：:Megestrol acetate, an appetite stimulant with low bioavailability, shows increased bioavailability when taken together with food. However, the pharmacokinetic characteristics of megestrol acetate and its relation with food are not well understood. This study aimed to investigate the food effect on the pharmacokinetics...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guk J,Son H,Chae DW,Park K

更新日期：2017-03-01 00:00:00

abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saario SM,Laitinen JT

更新日期：2007-11-01 00:00:00

abstract：:Selenium is an essential trace element with growth-modulating properties. Decades of research clearly demonstrate that selenium compounds inhibit the growth of malignant cells in diverse experimental model systems. However, the growth-modulating and cytotoxic mechanisms are diverse and far from clear. Lately, a remark...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wallenberg M,Misra S,Björnstedt M

更新日期：2014-05-01 00:00:00

abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2007-11-01 00:00:00

abstract：:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto...

journal_title：Basic & clinical pharmacology & toxicology

authors： Han L,Howe JR,Pickering DS

更新日期：2016-08-01 00:00:00

abstract：:Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. H...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim KH,Kum YS,Park YY,Park JH,Kim SJ,Lee WR,Lee KG,Han SM,Park KK

更新日期：2010-07-01 00:00:00

abstract：:Cytochrome P450 2C8 (CYP2C8) plays important roles in the metabolism of various drugs, including the anti-cancer drug, paclitaxel. We recently identified two novel CYP2C8 alleles (CYP2C8*13 and CYP2C8*14; wild-type, CYP2C8*1A) with non-synonymous single nucleotide polymorphisms in a Japanese population. To precisely i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanioka N,Matsumoto K,Saito Y,Narimatsu S

更新日期：2010-07-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:The last eight survivors of 80 workers accidentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during production of herbicides based on trichlorophenoxyacetic acid in 1965-1967 in a chemical factory were followed. All were men, mean age 72.4 ± 1.3 years. Their current median TCDD blood level was 112 (46-390...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pelclova D,Urban P,Fenclova Z,Vlckova S,Ridzon P,Kupka K,Meckova Z,Bezdicek O,Navratil T,Rosmus J,Zakharov S

更新日期：2018-02-01 00:00:00