Abstract:
:Several investigations demonstrate that neurotoxins isolated from venoms of spiders and wasps may exert specific and selective activity on structures of the mammalian CNS. In the present work we examine the neurological effects of the low molecular weight compounds of the denatured venom of the neotropical social wasp Polybia occidentalis in freely moving rats. Central administration of denatured venom decreased the duration of exploratory, elevation and grooming behaviours on the open field. Moreover, denatured venom inhibited convulsing action of bicuculline (ED50 57 microg/microl), picrotoxin (ED50 75 microg/microl) and kainic acid (ED50 44 microg/microl), although it was ineffective against pentylenetetrazole-induced seizures. Despite of its inhibitory activity, toxic effects on motor performance examined in the rotarod test were not found, not even in extremely high doses. Also, denatured venom moderately reduced the spontaneous locomotor activity at anticonvulsant doses. These findings may indicate that the denatured venom has anticonvulsant activity with scarce propensity to cause neurological side-effects. Further studies are necessary to isolate the active compound and establish its mechanism of action.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Mortari MR,Cunha AO,de Oliveira L,Vieira EB,Gelfuso EA,Coutinho-Netto J,Ferreira dos Santos Wdoi
10.1111/j.1742-7843.2005.pto_137.xsubject
Has Abstractpub_date
2005-11-01 00:00:00pages
289-95issue
5eissn
1742-7835issn
1742-7843pii
PTOpto_137journal_volume
97pub_type
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