Oxidative DNA damage induced by ethanol in mouse peripheral leucocytes.

abstract：:Cell damage and spatial localization deficits are often reported as long-term consequences of pilocarpine-induced status epilepticus. In this study, we investigated the neuroprotective effects of repeated drug administration after long-lasting status epilepticus. Groups of six to eight Wistar rats received microinject...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cunha AO,Mortari MR,Liberato JL,dos Santos WF

更新日期：2009-06-01 00:00:00

abstract：:Mercury (Hg), a highly toxic environmental pollutant, shows harmfulness which still represents a big concern for human health, including hazards to fertility and pregnancy outcome. Research has shown that Hg could induce impairments in the reproductive function, cellular deformation of the Leydig cells and the seminif...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bjørklund G,Chirumbolo S,Dadar M,Pivina L,Lindh U,Butnariu M,Aaseth J

更新日期：2019-10-01 00:00:00

abstract：:Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord. The aim of the present study was to ascertain whether this pattern of COX-2 and COX-1 expression applies also to other pain conditions induced by surgical proc...

journal_title：Basic & clinical pharmacology & toxicology

authors： Prochazkova M,Dolezal T,Sliva J,Krsiak M

更新日期：2006-08-01 00:00:00

abstract：:Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irino...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jung GR,Kim KJ,Choi CH,Lee TB,Han SI,Han HK,Lim SC

更新日期：2007-10-01 00:00:00

abstract：:Whilst mitotic rat embryonic cardiomyoblast-derived H9c2 cells have been widely used as a model system to study the protective mechanisms associated with flavonoids, they are not fully differentiated cardiac cells. Hence, the aim of this study was to investigate the cardioprotective and cardiotoxic actions of querceti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Daubney J,Bonner PL,Hargreaves AJ,Dickenson JM

更新日期：2015-02-01 00:00:00

abstract：:The constitutive endothelial nitric oxide synthase (eNOS) plays a major role in circulatory homoeostasis and shows genetic polymorphism. eNOS is expressed and functional in blood cells, including erythrocytes. There is limited knowledge about the consequences of eNOS genetic variability in haemorheological parameters ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Babaoglu MO,Dikmenoglu N,Ileri-Gurel E,Seringec N,Zoto T,Yasar U,Kayaalp SO,Bozkurt A

更新日期：2011-03-01 00:00:00

abstract：:In previous studies we have reported that NQ301, a synthetic 1,4-naphthoquinone derivative, displays a potent antithrombotic activity, and that this might be due to antiplatelet effect, which was mediated by the inhibition of cytosolic Ca(2+) mobilization in activated platelets. In the present study, the effect of NQ3...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jin YR,Cho MR,Lee KS,Lee JJ,Lim Y,Han XH,Oh KW,Hong JT,Yoo HS,Yun YP

更新日期：2005-09-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of sodium nitrite (NaNO(2))-induced methemoglobinaemia on plasma ATP (adenosine triphosphate) and corresponding changes of blood-ionized magnesium (iMg(2+)) as well as total magnesium (tMg(2+)) in a time-dependent manner. This study was performed on male Sprague-...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rahman MM,Kim SJ,Kim GB,Hong CU,Lee YU,Kim SZ,Kim JS,Kang HS

更新日期：2009-11-01 00:00:00

abstract：:Juglone, a quinone isolated from Juglans mandshurica Maxim, has previously been shown to be effective against malignancy. The effect is at least partially due to stimulation of suicidal death or apoptosis of tumour cells. On the other hand, juglone has been shown to counteract apoptosis, for example, of neurons. In an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Calabrò S,Alzoubi K,Bissinger R,Jilani K,Faggio C,Lang F

更新日期：2015-06-01 00:00:00

abstract：:Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study with the objective to evaluate the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellfritzsch M,Pottegård A,Pedersen AJ,Burghle A,Mouaanaki F,Hallas J,Grove EL,Damkier P

更新日期：2017-04-01 00:00:00

abstract：:The antifungal ionophore nystatin dissipates the Na(+) and K(+) gradients across the cell membrane, leading to cellular gain of Na(+) and cellular loss of K(+) . The increase of cellular Na(+) concentration may result in Ca(2+) accumulation in exchange for Na(+) . Increase of cytosolic Ca(2+) activity ([Ca(2+) ]i ) an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Malik A,Bissinger R,Jilani K,Lang F

更新日期：2015-01-01 00:00:00

abstract：:This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Stage C,Jürgens G,Guski LS,Thomsen R,Bjerre D,Ferrero-Miliani L,Lyauk YK,Rasmussen HB,Dalhoff K,INDICES Consortium (for members of this consortium-see Supplementum).

更新日期：2017-12-01 00:00:00

abstract：:This study investigates the oxidative damage of biomolecules in livers of mice treated with morphine intraperitoneally. The oxidative damage of DNA as measured by single cell electrophoresis and high-performance liquid chromatography equipped with electrochemical and UV detection, the protein carbonyl content was meas...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang YT,Zheng QS,Pan J,Zheng RL

更新日期：2004-08-01 00:00:00

abstract：:Although commonly associated with obesity, non-alcoholic fatty liver disease (NAFLD) is also present in the lean population representing a unique disease phenotype. Affecting 25% of the world's population, NAFLD is associated with increased mortality especially when progressed to non-alcoholic steatohepatitis (NASH). ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ipsen DH,Rolin B,Rakipovski G,Skovsted GF,Madsen A,Kolstrup S,Schou-Pedersen AM,Skat-Rørdam J,Lykkesfeldt J,Tveden-Nyborg P

更新日期：2018-12-01 00:00:00

abstract：:Omeprazole is one of the most widely used proton pump inhibitors for the treatment of gastric acid-related disorders. The major metabolic pathway of omeprazole is 5-hydroxylation, which is catalysed by CYP2C19. In this study, the effect of CYP2C19*18 and CYP2C19*19 alleles on omeprazole 5-hydroxylation was studied usi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hanioka N,Tsuneto Y,Saito Y,Maekawa K,Sawada J,Narimatsu S

更新日期：2008-04-01 00:00:00

abstract：:Three diterpenoid quinones (royleanone- SAR 3, horminone- SAR 26, and acetyl horminone- SAR 43) isolated from the roots of Salvia officinalis L. were tested for their cytotoxic and DNA-damaging activity in human colon carcinoma cells Caco-2 and human hepatoma cells HepG2 cultured in vitro. Cytotoxicity was measured by...

journal_title：Basic & clinical pharmacology & toxicology

authors： Slamenová D,Masterová I,Lábaj J,Horváthová E,Kubala P,Jakubíková J,Wsólová L

更新日期：2004-06-01 00:00:00

abstract：:Previous studies have shown that generation of free radicals is increased following pentylenetetrazol kindling, due to increased cytosolic Ca2+ concentrations. Topiramate, a voltage-gated calcium channel inhibitor, has an evident effect in the treatment of childhood epilepsy; however, topiramate may cause nephrotoxici...

journal_title：Basic & clinical pharmacology & toxicology

authors： Armagan A,Kutluhan S,Yilmaz M,Yilmaz N,Bülbül M,Vural H,Soyupek S,Naziroglu M

更新日期：2008-08-01 00:00:00

abstract：:Since the 1970s, we have known that aspirin can reduce the risk of pre-eclampsia. However, the underlying mechanisms explaining this risk reduction are poorly understood. Both cyclooxygenase (COX)-1- and COX-2-dependent effects might be involved. As a consequence of this knowledge hiatus, the optimal dose and timing o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mirabito Colafella KM,Neuman RI,Visser W,Danser AHJ,Versmissen J

更新日期：2020-08-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kanno S,Uwai K,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Takeshita M,Ohtake T,Kimura K,Ishikawa M

更新日期：2006-01-01 00:00:00

abstract：:Alcohol consumption increases apoptosis of hepatocytes. Death of hepatocytes is a characteristic feature of chronic liver disease for various causes. Bee venom (Apis mellifera) has been traditionally used for the treatment of various chronic diseases, such as chronic inflammatory arthritis and chronic liver disease. H...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim KH,Kum YS,Park YY,Park JH,Kim SJ,Lee WR,Lee KG,Han SM,Park KK

更新日期：2010-07-01 00:00:00

abstract：:The aim of the present study was to investigate the effect of intraperitoneal administration of caffeic acid (0.5, 1, 2, 4 or 8 mg/kg) on elevated plus-maze and open field tasks in rats and its possible neuroprotection/neurotoxicity using the comet assay. Caffeic acid at 1 mg/kg increased the number of entries and the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pereira P,de Oliveira PA,Ardenghi P,Rotta L,Henriques JA,Picada JN

更新日期：2006-11-01 00:00:00

abstract：:Rapamycin is a macrocyclic lactone currently used for the treatment of cancer and for the prevention of transplant rejection. The primary pharmacological mode of action of rapamycin occurs through the inhibition (blocking) of the mammalian target of rapamycin (mTOR). By doing so, rapamycin interferes with the phosphoi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fagone P,Donia M,Mangano K,Quattrocchi C,Mammana S,Coco M,Libra M,McCubrey JA,Nicoletti F

更新日期：2013-01-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:Hepatocellular carcinoma (HCC) is the third most common cause of cancer-related death. In patients for whom HCC could not be detected early, current treatments show poor tolerance and low efficacy. So, alternative therapies with good efficacy are urgently needed. The aim of this research was to evaluate the selective ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Seydi E,Rasekh HR,Salimi A,Mohsenifar Z,Pourahmad J

更新日期：2016-09-01 00:00:00

abstract：:The activation of Nod-like receptor protein 3 (NLRP3) has lately been implicated in stress and depression as an initiator mechanism required for the production of interleukin (IL)-1β and IL-18. Agmatine, an endogenous polyamine widely distributed in mammalian brain, is a novel neurotransmitter/neuromodulator, with ant...

journal_title：Basic & clinical pharmacology & toxicology

authors： Sahin C,Albayrak O,Akdeniz TF,Akbulut Z,Yanikkaya Demirel G,Aricioglu F

更新日期：2016-10-01 00:00:00

abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saario SM,Laitinen JT

更新日期：2007-11-01 00:00:00

abstract：:Our previous studies with the use of non-selective cyclooxygenase (COX) inhibitor, indomethacin, demonstrated that prostanoids produced during endotoxaemia increase inducible nitric oxide synthase (iNOS) protein expression and nitric oxide synthesis, and decrease cyctochrome P450 (CYP) 4A1 protein expression and CYP 4...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tunctan B,Korkmaz B,Cuez T,Kemal Buharalioglu C,Sahan-Firat S,Falck J,Malik KU

更新日期：2010-11-01 00:00:00

abstract：:Nicotine-methadone interactions have been studied in human beings and in various experimental settings regarding addiction, reward and pain. Most methadone maintenance treatment patients are smokers, and methadone administration has been shown to increase cigarette smoking. Previous in vitro studies have shown that me...

journal_title：Basic & clinical pharmacology & toxicology

authors： Talka R,Salminen O,Tuominen RK

更新日期：2015-04-01 00:00:00

abstract：:In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predict...

journal_title：Basic & clinical pharmacology & toxicology

authors： Petersen TK

更新日期：2006-08-01 00:00:00