Abstract：
:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is general debate on how and when data mining should be best performed. While the cornerstone principles for data mining of spontaneous reports have been in place since the 1960s, several significant changes have occurred to make their use widespread. Superficially the Bayesian methods seem unnecessarily complex, particularly given the nature of the data, but in practice implementation in Bayesian framework gives clear benefits. There are difficulties evaluating the performance of the methods, but they work and save resources in managing large data sets. The use of neural networks allows more sophisticated pattern recognition to be performed.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Bate A,Edwards IRdoi
10.1111/j.1742-7843.2006.pto_232.xsubject
Has Abstractpub_date
2006-03-01 00:00:00pages
324-30issue
3eissn
1742-7835issn
1742-7843pii
PTOpto_232journal_volume
98pub_type
杂志文章,评审abstract：:Epidemiological and animal studies show that small changes in the developmental environment can induce phenotypic changes affecting an individual's responses to their later environment. These may alter the risk of chronic disease such as metabolic syndrome or cardiovascular disease. Recent research shows that animals ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2007.00186.x
更新日期：2008-02-01 00:00:00
abstract：:Our objective was to identify the cytochrome P450 (CYP) enzymes that metabolise pioglitazone and to examine the effects of the CYP2C8 inhibitors montelukast, zafirlukast, trimethoprim and gemfibrozil on pioglitazone metabolism in vitro. The effect of different CYP isoform inhibitors on the elimination of a clinically ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_437.x
更新日期：2006-07-01 00:00:00
abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2007.00053.x
更新日期：2007-05-01 00:00:00
abstract：:We investigated the effects of (1,4)-alpha-D-glucan (alpha-DG), a novel immune stimulatory drug from Tinospora cordifolia, on the concentration of pro- and anti-inflammatory cytokines (interleukin [IL]-1beta, IL-6, tumour necrosis factor-alpha [TNF-alpha], gamma-interferon [IFN-gamma] and IL-10) in the lung and spleen...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00447.x
更新日期：2009-11-01 00:00:00
abstract：:Several investigations demonstrate that neurotoxins isolated from venoms of spiders and wasps may exert specific and selective activity on structures of the mammalian CNS. In the present work we examine the neurological effects of the low molecular weight compounds of the denatured venom of the neotropical social wasp...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2005.pto_137.x
更新日期：2005-11-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2011.00700.x
更新日期：2011-09-01 00:00:00
abstract：:Naringin, an active flavonoid isolated from citrus fruit extracts, exhibits biological and pharmacological properties, such as antioxidant activity and antidiabetic effect. Mitogen-activated protein kinase (MAPK) signalling pathway has been shown to participate in hyperglycaemia-induced injury. The present study teste...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12153
更新日期：2014-04-01 00:00:00
abstract：:Since the introduction of antivenom administration over a century ago to treat venomous snake bite, it has been the most effective therapy for saving life and limb. However, this treatment is not always effective and not without potential life-threatening side effects. We tested a new paradigm to abrogate the plasmati...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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更新日期：2017-02-01 00:00:00
abstract：:In vitro studies have shown that vitamin D may induce several cytochrome P450 (CYP) enzymes in general and CYP3A4 in particular. The primary aim of this study was to investigate the relationship between plasma levels of 25-hydroxyvitamin D3 and suggested in vivo markers of CYP3A activity in healthy volunteers from Swe...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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更新日期：2014-10-01 00:00:00
abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...
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doi：10.1111/bcpt.13456
更新日期：2020-12-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,meta分析
doi：10.1111/j.1742-7843.2008.00300.x
更新日期：2008-11-01 00:00:00
abstract：:Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity to different tumour cell lines. α-Eudesmol showed IC₅₀ values ranging from 5.38 ± 1.10 to 10.60 ± 1.33 μg/mL for B16-F10 and K562 cell lines, β-eudesmol showed I...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12097
更新日期：2013-11-01 00:00:00
abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00625.x
更新日期：2011-02-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2011.00673.x
更新日期：2011-07-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章
doi：10.1111/bcpt.12042
更新日期：2013-05-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12722
更新日期：2017-04-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_250.x
更新日期：2006-04-01 00:00:00
abstract：:The advent of large population-based prescription databases has enabled us to study drug use with the individual user as our unit of analysis. This review presents three non-specific analytic templates that may be applied to individual-level prescription data. The ratio of prevalence odds to incidence rate can estimat...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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更新日期：2010-11-01 00:00:00
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journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
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更新日期：2020-06-01 00:00:00
abstract：:In recent years, several online tools have appeared capable of identifying potential plagiarism in science. While such tools may help to maintain or even increase the originality and ethical quality of the scientific literature, no apparent consensus exists among editors on the degree of plagiarism or self-plagiarism ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
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更新日期：2016-08-01 00:00:00
abstract：:The relationship between haem biosynthesis and intestinal iron absorption in mice was investigated by ascertaining the effect of the haem synthesis inhibitor, griseofulvin, on duodenal iron absorption using both in vivo and in vitro measurements. Urinary 5-aminolaevulinic acid levels were increased within 24 hr of fee...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2004.pto940402.x
更新日期：2004-04-01 00:00:00
abstract：:Non-alcoholic steatohepatitis (NASH) is a frequent condition in obese patients that may progress to end-stage liver disease. This study was designed to evaluate the modulation of this condition by use of quercetin (Q), a flavonoid largely found in vegetable foods, with known anti-inflammatory and antioxidant propertie...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,收录出版
doi：10.1111/bcpt.12049
更新日期：2013-06-01 00:00:00
abstract：:Evidence of poor prescribing is widespread including overuse of medicines, underuse of effective medicines, avoidable adverse drug reactions and medication errors. Junior doctors who have recently graduated are responsible for much of the prescribing that takes place in hospitals and are implicated in many of the adve...
journal_title：Basic & clinical pharmacology & toxicology
pub_type：
doi：10.1111/j.1742-7843.2007.00141.x
更新日期：2007-12-01 00:00:00
abstract：:Delta-9-tetrahydrocannabinol (THC), the main psychoactive cannabinoid in cannabis, may inhibit the cytochrome P450 enzyme CYP2C9. Consequently, cannabis use might infer a risk of drug-drug interaction with substrates for this enzyme, which includes drugs known to have a narrow therapeutic window. In this study, we des...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.13152
更新日期：2019-01-01 00:00:00
