Immunological response to (1,4)-alpha-D-glucan in the lung and spleen of endotoxin-stimulated juvenile rats.

abstract：:At the time that Paracelsus coined his famous dictum, 'What is there that is not poison? All things are poison and nothing is without poison. Solely the dose determines that a thing is not a poison', embryonic toxicology was a fairly focused discipline that mainly dealt with occupational poisonings and side effects of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Grandjean P

更新日期：2016-08-01 00:00:00

abstract：:This study investigated the antinociceptive effects of zerumbone in chemical behavioural models of nociception in mice. Zerumbone given through intraperitoneal route (i.p.) produced dose-related antinociception when assessed on acetic acid-induced abdominal writhing test in mice. In addition, the i.p. administration o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Perimal EK,Akhtar MN,Mohamad AS,Khalid MH,Ming OH,Khalid S,Tatt LM,Kamaldin MN,Zakaria ZA,Israf DA,Lajis N,Sulaiman MR

更新日期：2011-03-01 00:00:00

abstract：:N-methyl-D-aspartate (NMDA) receptors are ionotropic glutamate receptors widely distributed in the central nervous system, and have been extensively investigated for their roles in embryonic development, synaptic plasticity and neuroexcitoxicity. Their functions in the peripheral nervous system and non-neural tissues ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shen L,Li L,She H,Yue S,Li C,Luo Z

更新日期：2010-09-01 00:00:00

abstract：:Maximizing the likelihood of success in Phase III is the ultimate goal of the use of modelling and simulation in the drug development process. The success in Phase III depends primarily on two questions: 1) Is the drug regimen actually efficacious and safe in the targeted patient population?, and 2) Will the planned P...

journal_title：Basic & clinical pharmacology & toxicology

authors： De Ridder F

更新日期：2005-03-01 00:00:00

abstract：:Faldaprevir (FDV) is a potent, orally administered inhibitor of hepatitis C virus. In this single-centre, open-label, fixed-sequence, crossover study of 32 healthy adult male and female volunteers, subjects received either a single dose of cyclosporine (CsA) 50 mg (N = 16) or tacrolimus (TAC) 0.5 mg (N = 16), followed...

journal_title：Basic & clinical pharmacology & toxicology

authors： Huang F,Voelk C,Trampisch M,Rowland L,Schultz A,Sabo JP

更新日期：2018-07-01 00:00:00

abstract：:The endothelium plays crucial roles in modulating vascular tone by synthesizing and releasing endothelium-derived relaxing factors (EDRFs), including vasodilator prostaglandins, nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) factors. Thus, endothelial dysfunction is the hallmark of atherosclerotic...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shimokawa H,Godo S

更新日期：2020-08-01 00:00:00

abstract：:In this MiniReview, we provide general considerations for the planning and conduct of pharmacoepidemiological studies of associations between drug use and cancer development. We address data sources, study design, assessment of drug exposure, ascertainment of cancer outcomes, confounder adjustment and future perspecti...

journal_title：Basic & clinical pharmacology & toxicology

authors： Pottegård A,Friis S,Stürmer T,Hallas J,Bahmanyar S

更新日期：2018-05-01 00:00:00

abstract：:QF-036 is an HIV-1 maturation inhibitor in pre-clinical development, and its antiviral activity against a laboratory HIV-1 strain and two drug-resistant strains was determined in the C8166 line. QF-036 was also subjected to absorption, distribution and metabolism (ADM) assessment in vitro, and pharmacokinetic profiles...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao L,He HH,Ou-Yang T,Liu DF,Jiang CH,Yang HP,Wang P,Xie N,Yan SS

更新日期：2021-02-01 00:00:00

abstract：:Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, health...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saruwatari J,Takashima A,Yoshida K,Soraoka H,Ding TB,Uchiyashiki Y,Tsuda Y,Imamura M,Oniki K,Miyata K,Nakagawa K

更新日期：2014-10-01 00:00:00

abstract：:To investigate the transplacental transport of pesticides, the pyrethroid cypermethrin and the fungicide azoles, propiconazole and bitertanol were tested in the placental perfusion model. Cypermethrin, propiconazole and bitertanol were also tested in the BeWo cell transfer model. The pesticides were chosen with the se...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mathiesen L,Mørck TA,Poulsen MS,Nielsen JKS,Mose T,Long M,Bonefeld-Jørgensen E,Bossi R,Knudsen LE

更新日期：2020-12-01 00:00:00

abstract：:Obesity is an increasing health problem, not only in developed countries but also all over the world. In addition to the focus on food intake and energy expenditure, current studies suggest two other important influences on adult body weight: birth weight and postnatal rate of growth. A common procedure in laboratory ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Coe BL,Kirkpatrick JR,Taylor JA,vom Saal FS

更新日期：2008-02-01 00:00:00

abstract：:Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, poor metabolizers (PM) and the remainder with preserved CYP2D6 activity, extensive metabolizers ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zwisler ST,Enggaard TP,Noehr-Jensen L,Pedersen RS,Mikkelsen S,Nielsen F,Brosen K,Sindrup SH

更新日期：2009-04-01 00:00:00

abstract：:Epidemiological data have shown that methamphetamine (MA) abuse significantly increases the risk of developing pulmonary arterial hypertension (PAH). To investigate whether MA could induce PAH and its possible mechanism, rats were exposed daily to MA for 5 weeks in the absence or presence of fluoxetine. The results sh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu M,Wang Y,Wang HM,Bai Y,Zhang XH,Sun YX,Wang HL

更新日期：2013-02-01 00:00:00

abstract：:This study was designed to investigate the therapeutic effect of sodium formononetin-3'-sulphonate (Sul-F), a water-soluble derivate of formononetin, on acute myocardial infarction in rats. The results showed that treatment with Sul-F significantly prevented the elevation of ST-segment level, decreased the contents of...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang S,Tang X,Tian J,Li C,Zhang G,Jiang W,Zhang Z

更新日期：2011-06-01 00:00:00

abstract：BACKGROUND:There are inadequate data on prescribed drug utilization in Sub-Saharan Africa (SSA). Drug utilization research (DUR) in this region is hampered by lack of access to databases that capture prescribed drug utilization such as health insurance claims, electronic medical records and disease registries. The prim...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ankrah D,Hallas J,Odei J,Asenso-Boadi F,Dsane-Selby L,Donneyong M

更新日期：2019-01-01 00:00:00

abstract：:The constitutive endothelial nitric oxide synthase (eNOS) plays a major role in circulatory homoeostasis and shows genetic polymorphism. eNOS is expressed and functional in blood cells, including erythrocytes. There is limited knowledge about the consequences of eNOS genetic variability in haemorheological parameters ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Babaoglu MO,Dikmenoglu N,Ileri-Gurel E,Seringec N,Zoto T,Yasar U,Kayaalp SO,Bozkurt A

更新日期：2011-03-01 00:00:00

abstract：:Previous studies suggest that flavonol icariin protects against neuron injury after oxygen and glucose deprivation by increasing SIRT1. This study demonstrates that icariin can inhibit H(2) O(2) -induced neurotoxicity. The neuroprotection of icariin enhances the antioxidant capacity through both a direct scavenging ef...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang L,Huang S,Chen Y,Wang Z,Li E,Xu Y

更新日期：2010-11-01 00:00:00

abstract：:Natural oils are extensively used in cosmetics and as treatment for a growing number of more or less specific ailments. Skin irritation and cases of allergy have repeatedly been described in the literature following exposure to these oils. The present study evaluated the extent to which three natural oils (eucalyptus ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nielsen JB

更新日期：2006-06-01 00:00:00

abstract：:We aimed to determine the acute physiology and chronic health evaluation (APACHE) II and simplified acute physiology score (SAPS) II in poisoned patients admitted to the poisoning ICU and compare them to see which is a more sensitive and specific system for prognostication of the mortality and complications in these p...

journal_title：Basic & clinical pharmacology & toxicology

authors： Alizadeh AM,Hassanian-Moghaddam H,Shadnia S,Zamani N,Mehrpour O

更新日期：2014-09-01 00:00:00

abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2008-05-01 00:00:00

abstract：:Curcumin is the effective ingredient of turmeric, sometimes used as a painkiller in traditional medicine. It has extensive biological properties such as anti-inflammatory and antioxidant activities. SARS-CoV-2 is a betacoronavirus developing severe pneumonitis. Inflammasome is one of the most important components of i...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saeedi-Boroujeni A,Mahmoudian-Sani MR,Bahadoram M,Alghasi A

更新日期：2021-01-01 00:00:00

abstract：:To study the potential interactions of naringin (NAR), talinolol (TAL) and protein-energy undernutrition (PEU) in the absorption process of saquinavir (SQV), perfusion experiments were performed in the small intestine of rats at different SQV concentrations. The results obtained demonstrated that SQV intestinal absorp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Catalán-Latorre A,Nácher A,Merino V,Jiménez-Torres NV,Merino-Sanjuán M

更新日期：2011-10-01 00:00:00

abstract：:Primary or acquired resistance of tumours to established chemotherapeutic regimens is a major concern in oncology. Attempts to improve the survival of cancer patients largely depend on strategies to prevent tumour cell resistance. 5-Fluorouracil (5-FU)-based chemotherapy with a combination of other drugs such as irino...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jung GR,Kim KJ,Choi CH,Lee TB,Han SI,Han HK,Lim SC

更新日期：2007-10-01 00:00:00

abstract：:Amyotrophic lateral sclerosis (ALS) affects anterior horn cells of the spinal cord causing an indolent slow and steady deterioration of muscle strength leading inevitably to death in respiratory failure. ALS is a model condition for neurodegenerative disorders. Exposure to different agents dispersed in the environment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Roos PM,Dencker L

更新日期：2012-08-01 00:00:00

abstract：:Nitric oxide (NO) is an important signalling molecule that has been suggested to be a key molecule for induction and maintenance of migraine attacks based on clinical studies, animal experimental studies and the expression of nitric oxide synthase (NOS) immunoreactivity within the trigeminovascular system. Sensitisati...

journal_title：Basic & clinical pharmacology & toxicology

authors： Jansen-Olesen I,Zhou M,Zinck T,Xu CB,Edvinsson L

更新日期：2005-12-01 00:00:00

abstract：:Hypotensive effects of oral sodium nitrite have been reported as alternative sources of nitric oxide (NO) formation in animals and human beings. Reductions in NO bioavailability were observed in lead-induced hypertension. However, no previous study has examined whether a single daily dose of sodium nitrite prevents th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Gonçalves-Rizzi VH,Nascimento RA,Possomato-Vieira JS,Dias-Junior CA

更新日期：2016-03-01 00:00:00

abstract：:There is an obvious urgent need to find effective and safe therapies to prevent both recurrence and progression of bladder cancer. In the present study, we report that fisetin-induced apoptosis in human bladder cancer is mediated via modulation of two related pathways: up-regulation of p53 and down-regulation of NF-ka...

journal_title：Basic & clinical pharmacology & toxicology

authors： Li J,Cheng Y,Qu W,Sun Y,Wang Z,Wang H,Tian B

更新日期：2011-02-01 00:00:00

abstract：:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto...

journal_title：Basic & clinical pharmacology & toxicology

authors： Han L,Howe JR,Pickering DS

更新日期：2016-08-01 00:00:00

abstract：:The currently recommended first-line treatments of erectile dysfunction (ED), phosphodiesterase type 5 inhibitors (PDE5i), for example sildenafil, are efficacious in many patients with ED of vascular origin, but this therapy is insufficient in approximately 30-40% of men with ED where there is also a neuronal affectio...

journal_title：Basic & clinical pharmacology & toxicology

authors： Simonsen U,Comerma-Steffensen S,Andersson KE

更新日期：2016-10-01 00:00:00

abstract：:The era of immunotherapies was unleashed in 2010 with the Food and Drug Administration (FDA) approval of the first therapeutic vaccine sipuleucel-T as a standard treatment for metastatic prostate cancer. Next, the first immune-activating anticytotoxic lymphocyte antigen-4 (CTLA-4) antibody ipilimumab exhibiting 'immun...

journal_title：Basic & clinical pharmacology & toxicology

authors： Iversen TZ,Andersen MH,Svane IM

更新日期：2015-01-01 00:00:00