Structural insight into Class F receptors - What have we learnt regarding agonist-induced activation?

abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

更新日期：2018-04-01 00:00:00

abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Sepsova V,Tumova M,Horova A,Musilek K

更新日期：2015-04-01 00:00:00

abstract：:Annona vepretorum Mart. (Annonaceae), popularly known as 'bruteira', has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with β-cyclodextrin in a microencapsulation. The essential oil was obtained b...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bomfim LM,Menezes LR,Rodrigues AC,Dias RB,Rocha CA,Soares MB,Neto AF,Nascimento MP,Campos AF,Silva LC,Costa EV,Bezerra DP

更新日期：2016-03-01 00:00:00

abstract：BACKGROUND:There are inadequate data on prescribed drug utilization in Sub-Saharan Africa (SSA). Drug utilization research (DUR) in this region is hampered by lack of access to databases that capture prescribed drug utilization such as health insurance claims, electronic medical records and disease registries. The prim...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ankrah D,Hallas J,Odei J,Asenso-Boadi F,Dsane-Selby L,Donneyong M

更新日期：2019-01-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) has been connected to learning, memory and mood. Changes in serum or plasma POP activity have been linked to psychiatric disorders. POP has been thought to interfere in these conditions by cleaving neuroactive peptides or via the phosphatidylinositol second messenger system. However, little...

journal_title：Basic & clinical pharmacology & toxicology

authors： Peltonen I,Männistö PT

更新日期：2011-01-01 00:00:00

abstract：:Melatonin possesses chronobiotic properties, which affects sleep/wake rhythms. We investigated a 7-day administration of melatonin (0.25, 2.5 and 5 mg/kg body weight) on the activity/rest rhythms of a diurnal animal (the ringdove, Streptopelia risoria), aged 2-3 (young) and 10-12 (old) years, and its possible relation...

journal_title：Basic & clinical pharmacology & toxicology

authors： Paredes SD,Terrón MP,Valero V,Barriga C,Reiter RJ,Rodríguez AB

更新日期：2007-04-01 00:00:00

abstract：:Metformin is an antidiabetic drug recently shown to inhibit cancer cell proliferation and growth, although the involved molecular mechanisms have not been elucidated. In many cancer cells, high expression of thymidine phosphorylase (TP) and Excision repair cross-complementation 1 (ERCC1) is associated with poor progno...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ko JC,Huang YC,Chen HJ,Tseng SC,Chiu HC,Wo TY,Huang YJ,Weng SH,Chiou RY,Lin YW

更新日期：2013-07-01 00:00:00

abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2007-11-01 00:00:00

abstract：:Preliminary studies have found that the epigallocatechin gallate (EGCG) at proper concentration could promote development of pre-implantation mouse embryos in vitro. However, the underlying mechanisms have not been well understood. In this study, we collected 1-cell embryos from Kunming (KM) mice, cultured them in M16...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang W,Lv J,Zhang Y,Jiang Y,Chu C,Wang S

更新日期：2014-11-01 00:00:00

abstract：:Radial artery frequently develops spasm and requires vasodilator therapy during coronary artery bypass graft surgery (CABG). Levosimendan was recently shown to oppose 5-hydroxytryptamine-induced contraction of radial artery (RA) grafts. The aim of the present study was to explore whether levosimendan retains its vasod...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ambrus N,Szolnoky J,Pollesello P,Kun A,Varró A,Papp JG,Pataricza J

更新日期：2012-03-01 00:00:00

abstract：:Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hubacek JA,Pelclova D,Seidl Z,Vaneckova M,Klempir J,Ruzicka E,Ridzon P,Urban P,Fenclova Z,Petrik V,Diblik P,Kuthan P,Miovsky M,Janikova B,Adamkova V,Zakharov S

更新日期：2015-02-01 00:00:00

abstract：:Concurrent administration of chloramphenicol (CAP) with multivitamin-haematinics complex (MHC) is a common practice to cushioning anticipated anaemic effect of CAP in most developing countries. This study investigated the mechanism involved in CAP-induced reproductive toxicity as well as the effects of its co-administ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Oyagbemi AA,Adedara IA,Saba AB,Farombi EO

更新日期：2010-09-01 00:00:00

abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...

journal_title：Basic & clinical pharmacology & toxicology

authors： Shu W,Chen Y,Li R,Wu Q,Cui G,Ke W,Chen Z

更新日期：2008-12-01 00:00:00

abstract：:Epidemiological studies have suggested that human exposure to extremely low-frequency electromagnetic fields from the electric power and to mobile phone radiofrequency electromagnetic fields induce an increased risk of developing malignant tumours. However, no adequate laboratory data, in particular long-term carcinog...

journal_title：Basic & clinical pharmacology & toxicology

authors： Soffritti M,Giuliani L

更新日期：2019-08-01 00:00:00

abstract：:Trimidox (3,4,5-trihydroxybenzamidoxime) has been shown to reduce the activity of ribonucleotide reductase accompanied by growth inhibition and the differentiation of mammalian cells. Here we examine the induction of apoptosis by trimidox in several human leukaemia cell lines, focusing on the release of cytochrome c a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kanno S,Uwai K,Tomizawa A,Hiura T,Osanai Y,Ujibe M,Takeshita M,Ohtake T,Kimura K,Ishikawa M

更新日期：2006-01-01 00:00:00

abstract：:Vitamin K antagonists (VKA) are highly effective anticoagulants but their use is hampered by multiple interactions with food and medicine and a narrow therapeutic range. The large variation in dose requirements has led to the development of several dosing algorithms based on pharmacogenetic and clinical variables. In ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Skov J,Bladbjerg EM,Rasmussen MA,Sidelmann JJ,Leppin A,Jespersen J

更新日期：2012-02-01 00:00:00

abstract：:Megestrol acetate, an appetite stimulant with low bioavailability, shows increased bioavailability when taken together with food. However, the pharmacokinetic characteristics of megestrol acetate and its relation with food are not well understood. This study aimed to investigate the food effect on the pharmacokinetics...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guk J,Son H,Chae DW,Park K

更新日期：2017-03-01 00:00:00

abstract：:To study the influence of single or repeated low-level sarin inhalation exposure on immune functions, inbred BALB/c mice were exposed to low clinically asymptomatic concentrations of sarin for 60 min. in the inhalation chamber. The evaluation of immune functions was carried out using phenotyping of CD3 (T-lymphocytes)...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Krocová Z,Sevelová L,Sheshko V,Kasalová I,Neubauerová V

更新日期：2004-03-01 00:00:00

abstract：:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is gene...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bate A,Edwards IR

更新日期：2006-03-01 00:00:00

abstract：:Fluorochemicals are a diverse group of synthetically produced compounds with the unique ability to repel water as well as oil. This property makes them ideal for multiple purposes in a variety of consumer and industrial products. Fluorochemicals have been detected in the environment, as well as in human blood, urine a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Taxvig C,Rosenmai AK,Vinggaard AM

更新日期：2014-07-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:The objective of this study was to evaluate the effects of sodium nitrite (NaNO(2))-induced methemoglobinaemia on plasma ATP (adenosine triphosphate) and corresponding changes of blood-ionized magnesium (iMg(2+)) as well as total magnesium (tMg(2+)) in a time-dependent manner. This study was performed on male Sprague-...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rahman MM,Kim SJ,Kim GB,Hong CU,Lee YU,Kim SZ,Kim JS,Kang HS

更新日期：2009-11-01 00:00:00

abstract：:Simvastatin (SV), a HMG-CoA reductase inhibitor, is widely used for the treatment of hyperlipidaemia. The objectives of the present study were to develop a population pharmacokinetic-pharmacodynamic (PK-PD) model for simvastatin and to evaluate its usefulness in predicting the dose-response relationship of simvastatin...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim J,Ahn BJ,Chae HS,Han S,Doh K,Choi J,Jun YK,Lee YW,Yim DS

更新日期：2011-09-01 00:00:00

abstract：:Snake venom components, acting in concert in the prey, cause their immobilization and initiate digestion. To achieve this, several hydrolytic enzymes of snake venom have evolved to interfere in various physiological processes, which are well defined. However, hydrolytic enzymes such as phosphatases (acid and alkaline ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dhananjaya BL,D'Souza CJ

更新日期：2011-02-01 00:00:00

abstract：:Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, health...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saruwatari J,Takashima A,Yoshida K,Soraoka H,Ding TB,Uchiyashiki Y,Tsuda Y,Imamura M,Oniki K,Miyata K,Nakagawa K

更新日期：2014-10-01 00:00:00

abstract：:There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mukherjee S,Saha N

更新日期：2018-03-01 00:00:00

abstract：:We searched PubMed entries and the Lattes database of Brazilian Pharmacogenetics Network investigators, for pharmacogenetic/genomic (PGx) studies in the Brazilian population, focusing on the drugs and genes included in the Clinical Pharmacogenetics Implementation Consortium (CPIC) guidelines. Warfarin was the most ext...

journal_title：Basic & clinical pharmacology & toxicology

authors： Rodrigues-Soares F,Suarez-Kurtz G

更新日期：2019-05-01 00:00:00

abstract：:Eudesmols are naturally occurring sesquiterpenoid alcohols that present cytotoxic effect to cancer cells. Herein, all eudesmol isomers displayed cytotoxicity to different tumour cell lines. α-Eudesmol showed IC₅₀ values ranging from 5.38 ± 1.10 to 10.60 ± 1.33 μg/mL for B16-F10 and K562 cell lines, β-eudesmol showed I...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bomfim DS,Ferraz RP,Carvalho NC,Soares MB,Pinheiro ML,Costa EV,Bezerra DP

更新日期：2013-11-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Several single nucleotide variations (SNVs) affect carboxylesterase 1 (CES1) activity, but the effects of genetic variants on CES1 gene expression have not been systematically investigated. Therefore, our aim was to investigate effects of genetic variants on CES1 gene expression in two independent whole blood sample c...

journal_title：Basic & clinical pharmacology & toxicology

authors： Neuvonen M,Tarkiainen EK,Tornio A,Hirvensalo P,Tapaninen T,Paile-Hyvärinen M,Itkonen MK,Holmberg MT,Kärjä V,Männistö VT,Neuvonen PJ,Pihlajamäki J,Backman JT,Niemi M

更新日期：2018-03-01 00:00:00