Post-Injection Delirium/Sedation Syndrome after Olanzapine Long-Acting Intramuscular Injection - Who is at Risk?

abstract：:Vitamin D deficiency seems to be implicated in the onset and progression of some autoimmune disorders. No previous study has investigated vitamin D homeostasis in post-partum thyroiditis. We compared 25-hydroxyvitamin D and parathyroid hormone (PTH) levels between four groups of non-lactating women who gave birth with...

journal_title：Basic & clinical pharmacology & toxicology

authors： Krysiak R,Kowalska B,Okopien B

更新日期：2015-06-01 00:00:00

abstract：:This study investigated the antinociceptive effects of zerumbone in chemical behavioural models of nociception in mice. Zerumbone given through intraperitoneal route (i.p.) produced dose-related antinociception when assessed on acetic acid-induced abdominal writhing test in mice. In addition, the i.p. administration o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Perimal EK,Akhtar MN,Mohamad AS,Khalid MH,Ming OH,Khalid S,Tatt LM,Kamaldin MN,Zakaria ZA,Israf DA,Lajis N,Sulaiman MR

更新日期：2011-03-01 00:00:00

abstract：:Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of generalized vitiligo. Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that ca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lan WJ,Wang HY,Lan W,Wang KY

更新日期：2008-07-01 00:00:00

abstract：:The present in vivo study investigated the genotoxicity of four dental resin monomers: triethyleneglycoldimethacrylate (TEGDMA), hydroxyethylmethacrylate (HEMA), urethanedimethacrylate (UDMA) and bisphenol A-glycidylmethacrylate (BisGMA). The Somatic Mutation and Recombination Test (SMART) in Drosophila melanogaster w...

journal_title：Basic & clinical pharmacology & toxicology

authors： Arossi GA,Lehmann M,Dihl RR,Reguly ML,de Andrade HH

更新日期：2010-02-01 00:00:00

abstract：:Rapamycin is a macrocyclic lactone currently used for the treatment of cancer and for the prevention of transplant rejection. The primary pharmacological mode of action of rapamycin occurs through the inhibition (blocking) of the mammalian target of rapamycin (mTOR). By doing so, rapamycin interferes with the phosphoi...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fagone P,Donia M,Mangano K,Quattrocchi C,Mammana S,Coco M,Libra M,McCubrey JA,Nicoletti F

更新日期：2013-01-01 00:00:00

abstract：:Pain involves responses in which both peripheral and central mechanisms contribute to the generation of pain. Pre-clinical laboratory data have supported that a topical formulation of combined diclofenac and methadone (Diclometh) may alleviate local pain, and potentially, the side effect profile should be low. We hypo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Larsen IM,Drewes AM,Olesen AE

更新日期：2018-08-01 00:00:00

abstract：:The present study was carried out to evaluate the ameliorative effects of kolaviron (a biflavonoid from the seeds of Garcinia kola) and curcumin (from the rhizome, Curcuma longa L.) on the di-n-butylphthalate (DBP)-induced testicular damage in rats. Administration of DBP to rats at a dose of 2 g/kg for 9 days signific...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farombi EO,Abarikwu SO,Adedara IA,Oyeyemi MO

更新日期：2007-01-01 00:00:00

abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ogur R,Uysal B,Ogur T,Yaman H,Oztas E,Ozdemir A,Hasde M

更新日期：2007-05-01 00:00:00

abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...

journal_title：Basic & clinical pharmacology & toxicology

authors： Faro LR,Alfonso M,Cervantes R,Durán R

更新日期：2009-12-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:To clarify the action of a side-effect of phenylbutazone, we investigated the inactivation of alpha(1)-antiproteinase induced by phenylbutazone in the presence of horseradish peroxidase (HRP) and H(2)O(2) (HRP-H(2)O(2)). The activity of alpha(1)-antiproteinase was rapidly lost during the interaction of phenylbutazone ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Muraoka S,Miura T

更新日期：2006-09-01 00:00:00

abstract：:Vitamin D metabolism was studied in primary human dermal fibroblasts with focus on drug-mediated gene regulation related to adverse side effects of antiretroviral drugs used in HIV therapy. The fibroblasts expressed mRNA for cytochrome P450 (CYP) enzymes catalysing bioactivating (CYP2R1, CYP27A1 and CYP27B1) and catab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Norlin M,Lundqvist J,Ellfolk M,Hellström Pigg M,Gustafsson J,Wikvall K

更新日期：2017-01-01 00:00:00

abstract：BACKGROUND:Long non-coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) is a novel vital oncogenic lncRNA that is dysregulated in various types of cancers, including glioma. According to TargetScan prediction, miR-432-5p is a target of ZFAS1. Herein, we aimed to determine whether there was a correlation between ZFAS1 a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang G,Han B,Feng T

更新日期：2019-12-01 00:00:00

abstract：:The purpose of this work was to obtain a suitable model of fibrosis, in which spontaneous reversion was minimal, to study the ability of silymarin, silibinin, colchicine and trimethylcolchicinic acid (TMCA) to reverse it. Reversal of liver fibrosis was studied in male Wistar rats after one, two or three months of CCl(...

journal_title：Basic & clinical pharmacology & toxicology

authors： Muriel P,Moreno MG,Hernández Mdel C,Chávez E,Alcantar LK

更新日期：2005-05-01 00:00:00

abstract：:Epidemiological data have shown that methamphetamine (MA) abuse significantly increases the risk of developing pulmonary arterial hypertension (PAH). To investigate whether MA could induce PAH and its possible mechanism, rats were exposed daily to MA for 5 weeks in the absence or presence of fluoxetine. The results sh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Liu M,Wang Y,Wang HM,Bai Y,Zhang XH,Sun YX,Wang HL

更新日期：2013-02-01 00:00:00

abstract：:Maximizing the likelihood of success in Phase III is the ultimate goal of the use of modelling and simulation in the drug development process. The success in Phase III depends primarily on two questions: 1) Is the drug regimen actually efficacious and safe in the targeted patient population?, and 2) Will the planned P...

journal_title：Basic & clinical pharmacology & toxicology

authors： De Ridder F

更新日期：2005-03-01 00:00:00

abstract：:Renal function impairment in lung cancer patients with bone metastases was investigated, as this can limit the application of bisphosphonates representing the gold standard in the management of such cases. Clinicopathological data of 570 lung cancer patients were retrospectively analysed for changes in renal function ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Fábián K,Puskás R,Kakuk T,Prés L,Fejes D,Szegedi Z,Rojkó L,Szállási Z,Döme B,Pipek O,Moldvay J

更新日期：2018-01-01 00:00:00

abstract：:The Consortium Linking Academic and Regulatory Insights on BPA Toxicity (CLARITY-BPA) involved the Food and Drug Administration, the National Toxicology Program and 14 academic investigators funded by the National Institute of Environmental Health Sciences. Two key questions to be answered by CLARITY-BPA were as follo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Vom Saal FS

更新日期：2019-08-01 00:00:00

abstract：:Prolyl oligopeptidase (POP) has been connected to learning, memory and mood. Changes in serum or plasma POP activity have been linked to psychiatric disorders. POP has been thought to interfere in these conditions by cleaving neuroactive peptides or via the phosphatidylinositol second messenger system. However, little...

journal_title：Basic & clinical pharmacology & toxicology

authors： Peltonen I,Männistö PT

更新日期：2011-01-01 00:00:00

abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellum BH,Nilsen OG

更新日期：2008-05-01 00:00:00

abstract：:Despite increased awareness and intensified biomedical research efforts, the prevalence of obesity continues to rise worldwide. This is alarming, because obesity accelerates the progression of several chronic disorders, including type 2 diabetes, cancer and cardiovascular disease. Individuals who experience significan...

journal_title：Basic & clinical pharmacology & toxicology

authors： Falk S,Lund C,Clemmensen C

更新日期：2020-06-01 00:00:00

abstract：:Hematide is a synthetic peptide-based, PEGylated erythropoiesis-stimulating agent, which is being developed for the chronic treatment of anaemia associated with chronic renal failure. To support the safety of long-term dosing of chronic renal failure patients, a comprehensive toxicology programme was implemented inclu...

journal_title：Basic & clinical pharmacology & toxicology

authors： Woodburn KW,Wilson SD,Fong KL,Schatz PJ,Spainhour CB,Norton D

更新日期：2009-02-01 00:00:00

abstract：:Type 1 diabetes mellitus (T1DM) is associated with several skeletal alterations, particularly in conditions of poor glycaemic control. Insulin therapy is the major conservative treatment for T1DM; however, the effects of this hormone on bone markers of T1DM rats are limited, and the regulatory mechanisms remain elusiv...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bortolin RH,Freire Neto FP,Arcaro CA,Bezerra JF,da Silva FS,Ururahy MA,Souza KS,Lima VM,Luchessi AD,Lima FP,Lia Fook MV,da Silva BJ,Almeida MD,Abreu BJ,de Rezende LA,de Rezende AA

更新日期：2017-03-01 00:00:00

abstract：:Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Origanum majorana L., Lamiaceae, is a potent antioxidant. The effect of administration of O. majorana (volatile oil, alcoholic and aqueous extracts) on oral administration of lead acetate in the diet of ...

journal_title：Basic & clinical pharmacology & toxicology

authors： el-Ashmawy IM,el-Nahas AF,Salama OM

更新日期：2005-10-01 00:00:00

abstract：:Vanishing bile duct syndrome is a severe cholestatic disease associated with toxic effects of medications. Stevens-Johnson syndrome is a hypersensitivity disorder that may also be caused by medications. We present a case of a 62-year-old male patient who developed vanishing bile duct syndrome a month after Stevens-Joh...

journal_title：Basic & clinical pharmacology & toxicology

authors： Juricic D,Hrstic I,Radic D,Skegro M,Coric M,Vucelic B,Francetic I

更新日期：2010-01-01 00:00:00

abstract：:The antifungal ionophore nystatin dissipates the Na(+) and K(+) gradients across the cell membrane, leading to cellular gain of Na(+) and cellular loss of K(+) . The increase of cellular Na(+) concentration may result in Ca(2+) accumulation in exchange for Na(+) . Increase of cytosolic Ca(2+) activity ([Ca(2+) ]i ) an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Malik A,Bissinger R,Jilani K,Lang F

更新日期：2015-01-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:Non-alcoholic steatohepatitis (NASH) is a frequent condition in obese patients that may progress to end-stage liver disease. This study was designed to evaluate the modulation of this condition by use of quercetin (Q), a flavonoid largely found in vegetable foods, with known anti-inflammatory and antioxidant propertie...

journal_title：Basic & clinical pharmacology & toxicology

authors： Marcolin E,Forgiarini LF,Rodrigues G,Tieppo J,Borghetti GS,Bassani VL,Picada JN,Marroni NP

更新日期：2013-06-01 00:00:00

abstract：:The specific protein target of delta9-tetrahydrocannabinol (delta9-THC), the main active ingredient of Cannabis sativa L., was characterized from rat brain nearly 20 years ago, and several endogenous compounds and proteins comprising the endocannabinoid (eCB) system have since been discovered. It has become evident th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Saario SM,Laitinen JT

更新日期：2007-11-01 00:00:00

abstract：:Our previous studies with the use of non-selective cyclooxygenase (COX) inhibitor, indomethacin, demonstrated that prostanoids produced during endotoxaemia increase inducible nitric oxide synthase (iNOS) protein expression and nitric oxide synthesis, and decrease cyctochrome P450 (CYP) 4A1 protein expression and CYP 4...

journal_title：Basic & clinical pharmacology & toxicology

authors： Tunctan B,Korkmaz B,Cuez T,Kemal Buharalioglu C,Sahan-Firat S,Falck J,Malik KU

更新日期：2010-11-01 00:00:00