Kolaviron, a natural antioxidant and anti-inflammatory phytochemical prevents dextran sulphate sodium-induced colitis in rats.

abstract：:Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant num...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lucafò M,Di Silvestre A,Romano M,Avian A,Antonelli R,Martelossi S,Naviglio S,Tommasini A,Stocco G,Ventura A,Decorti G,De Iudicibus S

更新日期：2018-01-01 00:00:00

abstract：:The aim is to emphasize the importance of extracardiac symptoms of digoxin intoxication in newborns. The most common intoxication symptoms in adults are of cardiac origin, but due to altered symptomatology, digoxin overdose in infants are not always discovered on symptomatic basis. In preterm infants, this is even mor...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nybo M,Damkier P

更新日期：2005-06-01 00:00:00

abstract：:Inosine monophosphate dehydrogenase (IMPDH) is considered as the limiting enzyme of thiopurine metabolism for the formation of 6-thioguanine nucleotides (6-TGN). No data are available on the influence of RBC IMPDH activity on the metabolism of thiopurine drugs in individuals with IBD. The aims of this study were as fo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Citterio-Quentin A,El Mahmoudi A,Perret T,Conway A,Ryan A,Beringer A,Lachaux A,Boulieu R

更新日期：2019-05-01 00:00:00

abstract：:Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Origanum majorana L., Lamiaceae, is a potent antioxidant. The effect of administration of O. majorana (volatile oil, alcoholic and aqueous extracts) on oral administration of lead acetate in the diet of ...

journal_title：Basic & clinical pharmacology & toxicology

authors： el-Ashmawy IM,el-Nahas AF,Salama OM

更新日期：2005-10-01 00:00:00

abstract：:Vitamin K antagonists (VKA) are highly effective anticoagulants but their use is hampered by multiple interactions with food and medicine and a narrow therapeutic range. The large variation in dose requirements has led to the development of several dosing algorithms based on pharmacogenetic and clinical variables. In ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Skov J,Bladbjerg EM,Rasmussen MA,Sidelmann JJ,Leppin A,Jespersen J

更新日期：2012-02-01 00:00:00

abstract：:Intravenous lipid emulsion has been suggested as treatment for severe intoxications caused by lipophilic drugs, including tricyclic antidepressants. We investigated the effect of lipid infusion on plasma and tissue concentrations of amitriptyline and haemodynamic recovery, when lipid was given after amitriptyline dist...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heinonen JA,Litonius E,Backman JT,Neuvonen PJ,Rosenberg PH

更新日期：2013-09-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:Preliminary studies have found that the epigallocatechin gallate (EGCG) at proper concentration could promote development of pre-implantation mouse embryos in vitro. However, the underlying mechanisms have not been well understood. In this study, we collected 1-cell embryos from Kunming (KM) mice, cultured them in M16...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhang W,Lv J,Zhang Y,Jiang Y,Chu C,Wang S

更新日期：2014-11-01 00:00:00

abstract：:In view of paediatric drug development, regulatory authorities often request safety studies in juvenile animals, including minipigs. Unfortunately, knowledge on the ontogeny of the biotransformation processes in animal models remains scarce and impedes a correct interpretation of the toxicity findings. CYP3A4 is one o...

journal_title：Basic & clinical pharmacology & toxicology

authors： Van Peer E,De Bock L,Boussery K,Van Bocxlaer J,Casteleyn C,Van Ginneken C,Van Cruchten S

更新日期：2015-11-01 00:00:00

abstract：:It is suggested that reactive oxygen species produced during ethanol intake may induce oxidative DNA damage. The present study, by the use of single cell gel electrophoresis (comet assay), investigated the potential genotoxicity of acute and long-term ethanol administration in mouse peripheral leucocytes. Urinary 8-hy...

journal_title：Basic & clinical pharmacology & toxicology

authors： Guo L,Yang JY,Wu CF

更新日期：2008-09-01 00:00:00

abstract：BACKGROUND:Long non-coding RNA (lncRNA) zinc finger antisense 1 (ZFAS1) is a novel vital oncogenic lncRNA that is dysregulated in various types of cancers, including glioma. According to TargetScan prediction, miR-432-5p is a target of ZFAS1. Herein, we aimed to determine whether there was a correlation between ZFAS1 a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang G,Han B,Feng T

更新日期：2019-12-01 00:00:00

abstract：:This study was undertaken in order to investigate a) the short- and long-term in vivo effects of cadmium (Cd) on brain acetylcholinesterase (AChE), (Na+, K+)-ATPase activities in adult rats, b) the concentration-dependent in vitro and in vivo (acute experiment) effects of Cd on the activity of those enzymes, c) the in...

journal_title：Basic & clinical pharmacology & toxicology

authors： Carageorgiou H,Tzotzes V,Pantos C,Mourouzis C,Zarros A,Tsakiris S

更新日期：2004-03-01 00:00:00

abstract：:Treatment for oral candidiasis in warfarin users may be complicated by drug-drug interactions (DDIs) between warfarin and topically applied antimycotics. However, current knowledge of these putative DDIs is merely based on case series. We therefore performed a cohort cross-over study with the objective to evaluate the...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hellfritzsch M,Pottegård A,Pedersen AJ,Burghle A,Mouaanaki F,Hallas J,Grove EL,Damkier P

更新日期：2017-04-01 00:00:00

abstract：:Geniposide is an iridoid glycoside isolated from the fruit of Gardenia jasminoides Ellis used as a Chinese traditional medicine for treatment of generalized vitiligo. Stem cell factor from keratinocyte recognizes and activates its receptor c-kit carried by melanocyte to potent enhance melanocytic melanogenesis that ca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lan WJ,Wang HY,Lan W,Wang KY

更新日期：2008-07-01 00:00:00

abstract：:While the physiological function and mechanisms of agonist-dependent G protein-coupled receptor (GPCR) internalization have been extensively studied, the functional characterization of constitutive internalization of these critically important receptors has received less attention. Here we relate the constitutive inte...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hendrik Schmidt J,Perslev M,Bukowski L,Stoklund M,Herborg F,Herlo R,Lindegaard Madsen K

更新日期：2020-06-01 00:00:00

abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...

journal_title：Basic & clinical pharmacology & toxicology

authors： Raaska K,Raitasuo V,Laitila J,Neuvonen PJ

更新日期：2004-01-01 00:00:00

abstract：:5-Hydroxytryptamine (5-HT) has been found to elicit enhanced contractile effects in some vascular disorders. The present study was designed to examine if vascular 5-HT2A receptors are up-regulated during organ culture and if the extracellular signal-regulated protein kinase 1/2 (ERK1/2) pathways are involved. Compared...

journal_title：Basic & clinical pharmacology & toxicology

authors： Cao YX,He LC,Xu CB,Luo GG,Edvinsson L

更新日期：2005-04-01 00:00:00

abstract：:Opioids given to pregnant and parturient women are relatively freely transferred across the placenta. Spinal, epidural and intravenous fentanyl has been studied in pregnant women and neonates, but foetal safety of fentanyl dosing with transdermal patch during pregnancy and labour is not sufficiently studied. Foetal pH...

journal_title：Basic & clinical pharmacology & toxicology

authors： Heikkinen EM,Kokki H,Heikkinen A,Ranta VP,Räsänen J,Voipio HM,Kokki M

更新日期：2017-02-01 00:00:00

abstract：:Cytochrome P450 3A4 (CYP3A4) is quantitatively the most important P450 enzyme in adults. It is suggested that CYP3A4 genetic polymorphisms may influence the rate of the metabolism and elimination of CYP3A4 substrates in human beings. Ibrutinib is an anticancer drug and primarily metabolized by CYP3A4. The aim of this ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Xu RA,Wen J,Tang P,Wang C,Xie S,Zhang BW,Zhou Q,Cai JP,Hu GX

更新日期：2018-04-01 00:00:00

abstract：:P-glycoprotein (P-gp), an important efflux transporter in intestine, regulates the bioavailability of orally taken drugs. To develop an in vitro model that preferably mimics the physiological microenvironment of human intestine, we employed the three-dimensionally (3D) cultured organoids from human normal small intest...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao J,Zeng Z,Sun J,Zhang Y,Li D,Zhang X,Liu M,Wang X

更新日期：2017-03-01 00:00:00

abstract：:Arsenic trioxide (As2O3) is used to treat acute pro-myelocytic leukaemia. However, the cardiotoxicity of long QT syndrome restricts its clinical application. Previous studies showed that As2O3 can damage the hERG current via disturbing its trafficking to cellular membrane. Consistent with these findings, in this study...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao X,Shi YQ,Yan CC,Feng PF,Wang X,Zhang R,Zhang X,Li BX

更新日期：2015-06-01 00:00:00

abstract：:The retinal fundus offers a rare opportunity to visualize the microcirculation in man using minimally invasive approaches. The purpose of this MiniReview is to summarize recent work on genetic and early life influences on the retinal microcirculation and to suggest how these observations may help inform our understand...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hughes AD

更新日期：2012-01-01 00:00:00

abstract：:There are various factors that contribute to development of antimicrobial resistance. Overuse, inappropriate prescribing and extensive agricultural use of antibiotics are some of the factors which have been identified. Antibiotics are almost always universally packaged by manufacturers in packs that are heavily driven...

journal_title：Basic & clinical pharmacology & toxicology

authors： Mukherjee S,Saha N

更新日期：2018-03-01 00:00:00

abstract：:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is gene...

journal_title：Basic & clinical pharmacology & toxicology

authors： Bate A,Edwards IR

更新日期：2006-03-01 00:00:00

abstract：:The advent of large population-based prescription databases has enabled us to study drug use with the individual user as our unit of analysis. This review presents three non-specific analytic templates that may be applied to individual-level prescription data. The ratio of prevalence odds to incidence rate can estimat...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hallas J,Støvring H

更新日期：2006-03-01 00:00:00

abstract：:This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Stage C,Jürgens G,Guski LS,Thomsen R,Bjerre D,Ferrero-Miliani L,Lyauk YK,Rasmussen HB,Dalhoff K,INDICES Consortium (for members of this consortium-see Supplementum).

更新日期：2017-12-01 00:00:00

abstract：:The study was designed to assess blood platelet sensitivity to acetylsalicylic acid and its associations with dyslipidaemia and inflammation in coronary artery disease patients. Platelet non-responsiveness to aspirin is associated with an increased risk of serious cardiovascular events. Several environmental and hered...

journal_title：Basic & clinical pharmacology & toxicology

authors： Markuszewski L,Rosiak M,Golanski J,Rysz J,Spychalska M,Watala C

更新日期：2006-05-01 00:00:00

abstract：:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto...

journal_title：Basic & clinical pharmacology & toxicology

authors： Han L,Howe JR,Pickering DS

更新日期：2016-08-01 00:00:00

abstract：:Brodalumab is a fully human monoclonal antibody targeting the IL-17 receptor A leading to an inhibition of the biological effect of IL-17A, IL-17F, IL-17A/F heterodimer, IL-17C and IL-17E isoforms. It has shown to be efficacious in the treatment of moderate to severe plaque psoriasis (210 mg administered subcutaneousl...

journal_title：Basic & clinical pharmacology & toxicology

authors： Timmermann S,Hall A

更新日期：2019-07-01 00:00:00

abstract：:QF-036 is an HIV-1 maturation inhibitor in pre-clinical development, and its antiviral activity against a laboratory HIV-1 strain and two drug-resistant strains was determined in the C8166 line. QF-036 was also subjected to absorption, distribution and metabolism (ADM) assessment in vitro, and pharmacokinetic profiles...

journal_title：Basic & clinical pharmacology & toxicology

authors： Zhao L,He HH,Ou-Yang T,Liu DF,Jiang CH,Yang HP,Wang P,Xie N,Yan SS

更新日期：2021-02-01 00:00:00