Enhanced transcription of contractile 5-hydroxytryptamine 2A receptors via extracellular signal-regulated kinase 1/2 after organ culture of rat mesenteric artery.

abstract：:The reactivating and therapeutic efficacy of three original bispyridinium oximes (K727, K733 and K203) and one currently available oxime (trimedoxime) was evaluated in tabun-poisoned rats and mice. The oxime-induced reactivation of tabun-inhibited acetylcholinesterase was measured in diaphragm and brain of tabun-poiso...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kassa J,Sepsova V,Tumova M,Horova A,Musilek K

更新日期：2015-04-01 00:00:00

abstract：:Several studies in the Northeastern region of Brazil have demonstrated an association between hypertension in adult populations and prenatal and postnatal undernutrition. The central hypothesis we proposed was that hypertension could be favoured by programmed alterations in branches of the renal arachidonic pathway an...

journal_title：Basic & clinical pharmacology & toxicology

authors： Silva LA,Veira-Filho LD,Barreto IS,Cabral EV,Vieyra A,Paixão AD

更新日期：2011-02-01 00:00:00

abstract：:Latex allergy is important due to serious health impacts and widespread use of its products. Latex allergic reactions can be induced in skin and mucosal surfaces including the respiratory tract. The development of murine models of allergic airway inflammation has provided a framework to dissect out the cellular and mo...

journal_title：Basic & clinical pharmacology & toxicology

authors： Farzaneh P,Hassan ZM,Pourpak Z,Hoseini AZ,Hogan SP

更新日期：2006-12-01 00:00:00

abstract：:Glucocorticoids (GCs) are widely employed in inflammatory, autoimmune and neoplastic diseases, and, despite the introduction of novel therapies, remain the first-line treatment for inducing remission in inflammatory bowel disease (IBD). Given the high incidence of suboptimal response, associated with a significant num...

journal_title：Basic & clinical pharmacology & toxicology

authors： Lucafò M,Di Silvestre A,Romano M,Avian A,Antonelli R,Martelossi S,Naviglio S,Tommasini A,Stocco G,Ventura A,Decorti G,De Iudicibus S

更新日期：2018-01-01 00:00:00

abstract：:Most steroid hormones are produced from cholesterol contained in low-density lipoproteins, which is uptaken by the gonads and adrenal cortex, and used as a substrate for steroidogenesis. Theoretically, in states associated with very low-density lipoprotein (LDL) cholesterol levels, cholesterol conversion to steroid ho...

journal_title：Basic & clinical pharmacology & toxicology

authors： Krysiak R,Okopien B

更新日期：2014-04-01 00:00:00

abstract：:In the last decades, a number of new antimuscarinic drugs have been introduced for treatment of the overactive bladder (OAB), defined symptomatically (OAB syndrome) or urodynamically (detrusor overactivity). Recently, three new drug principles have been approved for clinical use, the β3 -adrenoceptor agonist, mirabegr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Andersson KE

更新日期：2016-10-01 00:00:00

abstract：:Tamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30-100 times higher potency than the parent drug, no previous study has compared the effects produced by tamoxifen and its metab...

journal_title：Basic & clinical pharmacology & toxicology

authors： Montenegro MF,Pessa LR,Gomes VA,Desta Z,Flockhart DA,Tanus-Santos JE

更新日期：2009-05-01 00:00:00

abstract：:Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord. The aim of the present study was to ascertain whether this pattern of COX-2 and COX-1 expression applies also to other pain conditions induced by surgical proc...

journal_title：Basic & clinical pharmacology & toxicology

authors： Prochazkova M,Dolezal T,Sliva J,Krsiak M

更新日期：2006-08-01 00:00:00

abstract：:The aim of this study was to describe whether or not spinal anaesthesia with bupivacaine versus levobupivacaine has any effects on the QTc interval during caesarean section. Sixty healthy pregnant women scheduled for elective caesarean section were randomized to spinal anaesthesia with either bupivacaine (the bupivaca...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dogan Z,Yildiz H,Akcay A,Coskuner I,Arikan DC,Silay E,Akbudak IH,Kaya H,Oksuz H

更新日期：2014-03-01 00:00:00

abstract：:Cisplatin (CDDP) chemotherapy associated with radiation (RT) has been used in advanced head and neck squamous cell carcinoma (HNSCC) patients, and vomiting is a common side effect during treatment. This prospective study aimed to identify the roles of GSTM1 and GSTT1 (presents or nulls), GSTP1 c.313A>G, XPC c.2815A>C,...

journal_title：Basic & clinical pharmacology & toxicology

authors： Carron J,Lopes-Aguiar L,Costa EFD,Nogueira GAS,Lima TRP,Pincinato EC,Visacri MB,Quintanilha JCF,Moriel P,Lourenço GJ,Lima CSP

更新日期：2017-12-01 00:00:00

abstract：:Genetic polymorphisms influence the metabolism of ethanol and methanol, but the potential effects of genetic predisposition on the clinical course, outcome and short-term health sequelae of acute methanol poisoning are unknown. To evaluate the role of the MEOS system in methanol poisoning, we analysed the effect of th...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hubacek JA,Pelclova D,Seidl Z,Vaneckova M,Klempir J,Ruzicka E,Ridzon P,Urban P,Fenclova Z,Petrik V,Diblik P,Kuthan P,Miovsky M,Janikova B,Adamkova V,Zakharov S

更新日期：2015-02-01 00:00:00

abstract：:Interest in proteomics as a tool for drug development and a myriad of other applications continues to expand at a rapid rate. Proteomic analyses have recently been conducted on tissues, biofluids, subcellular components and enzymatic pathways as well as various disease and toxicological states, in both animal models a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Elrick MM,Walgren JL,Mitchell MD,Thompson DC

更新日期：2006-05-01 00:00:00

abstract：:Vascular networks are dynamic structures, adapting to changing conditions by structural remodelling of vessel diameters and by growth of new vessels and regression of existing vessels. The vast number of blood vessels in the circulatory system, more than 10⁹, implies that vessels' arrangement and structure are not und...

journal_title：Basic & clinical pharmacology & toxicology

authors： Secomb TW,Dewhirst MW,Pries AR

更新日期：2012-01-01 00:00:00

abstract：:Certain chemotherapeutic agents subject cells to oxidative stress, thereby promoting adverse effects. However, the molecular machinery governing 5-fluorouracil (5-FU)-mediated myelotoxicity is obscure. The purpose of this study was to clarify whether 5-FU-induced myelotoxicity is a cause of oxidative stress. Treatment...

journal_title：Basic & clinical pharmacology & toxicology

authors： Numazawa S,Sugihara K,Miyake S,Tomiyama H,Hida A,Hatsuno M,Yamamoto M,Yoshida T

更新日期：2011-01-01 00:00:00

abstract：:Pharmacokinetic/pharmacodynamic (PK/PD) models can be useful tools in new drug development and also optimal drug therapy in patients. This study was designed to develop a PK/PD model of sitagliptin based on the physiology of incretin. The PK/PD data included information derived from two different studies. Study 1 was ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Kim BH,Kim SE,Kang D,Lim KS,Kim JR,Jang IJ,Shin SG,Yoon SH,Cho JY,Yu KS

更新日期：2013-08-01 00:00:00

abstract：:Imbalanced matrix metalloproteinase (MMP) expression, including MMP-2, has been demonstrated in pre-eclampsia. However, little is known about the effect of polymorphisms in MMP-2 gene on hypertensive disorders of pregnancy. We examined whether two functional MMP-2 polymorphisms (g.-1306C>T and g.-735C>T) are associate...

journal_title：Basic & clinical pharmacology & toxicology

authors： Palei AC,Sandrim VC,Amaral LM,Machado JS,Cavalli RC,Lacchini R,Duarte G,Tanus-Santos JE

更新日期：2012-10-01 00:00:00

abstract：:Chemokines are chemotactic cytokines whose involvement in nociceptive processing is being increasingly recognized. Based on the previous description of the involvement of CC chemokine receptor type 1 (CCR1) in pathological pain, we have assessed the participation of CCR1 and its endogenous ligands CCL3 and CCL5 in hyp...

journal_title：Basic & clinical pharmacology & toxicology

authors： Llorián-Salvador M,González-Rodríguez S,Lastra A,Fernández-García MT,Hidalgo A,Menéndez L,Baamonde A

更新日期：2016-07-01 00:00:00

abstract：:While the physiological function and mechanisms of agonist-dependent G protein-coupled receptor (GPCR) internalization have been extensively studied, the functional characterization of constitutive internalization of these critically important receptors has received less attention. Here we relate the constitutive inte...

journal_title：Basic & clinical pharmacology & toxicology

authors： Hendrik Schmidt J,Perslev M,Bukowski L,Stoklund M,Herborg F,Herlo R,Lindegaard Madsen K

更新日期：2020-06-01 00:00:00

abstract：:Mesenchymal stem cells (MSCs) and MSC-derived small extracellular vesicles (sEVs) are promising candidates for cell-based and cell-free regenerative medicine, respectively. By virtue of their multiple lineage differentiation capacity, MSCs have been implicated as an ideal tool for bone and cartilage regeneration. Howe...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang X,Thomsen P

更新日期：2021-01-01 00:00:00

abstract：:Naringin, an active flavonoid isolated from citrus fruit extracts, exhibits biological and pharmacological properties, such as antioxidant activity and antidiabetic effect. Mitogen-activated protein kinase (MAPK) signalling pathway has been shown to participate in hyperglycaemia-induced injury. The present study teste...

journal_title：Basic & clinical pharmacology & toxicology

authors： Chen J,Guo R,Yan H,Tian L,You Q,Li S,Huang R,Wu K

更新日期：2014-04-01 00:00:00

abstract：:This study investigated the influence of variations in the carboxylesterase 1 gene (CES1) on the pharmacokinetics of enalapril. Forty-three healthy, Danish, Caucasian volunteers representing different pre-defined genotypes each received 10 mg of enalapril. At specified time-points, plasma concentrations of enalapril a...

journal_title：Basic & clinical pharmacology & toxicology

authors： Stage C,Jürgens G,Guski LS,Thomsen R,Bjerre D,Ferrero-Miliani L,Lyauk YK,Rasmussen HB,Dalhoff K,INDICES Consortium (for members of this consortium-see Supplementum).

更新日期：2017-12-01 00:00:00

abstract：:Although atracurium is a widely used neuromuscular blocker, we still lack knowledge regarding some of its cellular mechanisms of action. Thus, similar to other clinically used blockers atracurium induces, both in vivo and in vitro, fade of the tetanic contraction. However, the cellular mechanisms underlying this tetan...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nascimento DC,Serra CS,Oliveira AC

更新日期：2004-07-01 00:00:00

abstract：:The aim is to emphasize the importance of extracardiac symptoms of digoxin intoxication in newborns. The most common intoxication symptoms in adults are of cardiac origin, but due to altered symptomatology, digoxin overdose in infants are not always discovered on symptomatic basis. In preterm infants, this is even mor...

journal_title：Basic & clinical pharmacology & toxicology

authors： Nybo M,Damkier P

更新日期：2005-06-01 00:00:00

abstract：BACKGROUND:It is well known that antibiotic use is the main driver for the increasing problems with resistant bacteria. Consequently, some countries have recommended shortening the duration of antibiotic treatment of community-acquired pneumonia (CAP). The aim of this study was to investigate whether the effectiveness ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Møller Gundersen K,Nygaard Jensen J,Bjerrum L,Hansen MP

更新日期：2019-05-01 00:00:00

abstract：:Acidosis is one of the important deleterious factors during myocardial ischaemia and reperfusion. The ether-a-go-go-related gene, HERG, is a primary target for blockade by many drugs including dofetilide, quinidine and azimilide. While most drugs lose their efficacy against arrhythmias associated with myocardial ischa...

journal_title：Basic & clinical pharmacology & toxicology

authors： Dong DL,Li Z,Wang HZ,Du ZM,Song WH,Yang BF

更新日期：2004-05-01 00:00:00

abstract：:The aim of the study was to determine bone mineral density changes caused by consumption of cola drinks and the associated factors. Thirty Sprague-Dawley rats were divided into four groups. Groups 1 and 2, consisting of 10 male and 10 female rats, respectively, were provided with as much food, water and cola drinks as...

journal_title：Basic & clinical pharmacology & toxicology

authors： Ogur R,Uysal B,Ogur T,Yaman H,Oztas E,Ozdemir A,Hasde M

更新日期：2007-05-01 00:00:00

abstract：:The present study investigated the improving effect of cucurbitacin B on liver fibrosis induced by concanavalin A in mice and explored its possible mechanism. AST, ALT and TB were detected by kits. ELISA was performed to detect the levels of IL 5, IL 6, IL 13 and TNF-α in serum. Haematoxylin-eosin (HE) staining and Ma...

journal_title：Basic & clinical pharmacology & toxicology

authors： Yang L,Ao Q,Zhong Q,Li W,Li W

更新日期：2020-11-01 00:00:00

abstract：:In this study, we tested the hypothesis that fasudil, a Rho kinase inhibitor, would protect against contrast-induced acute kidney injury (CI-AKI) in a mouse model and attempted to elucidate the mechanism involved. Mice subjected to unilateral ligation of the left anterior renal pedicle were divided into four groups: (...

journal_title：Basic & clinical pharmacology & toxicology

authors： Wang Y,Zhang H,Yang Z,Miao D,Zhang D

更新日期：2018-02-01 00:00:00

abstract：:Obesity is an increasing health problem, not only in developed countries but also all over the world. In addition to the focus on food intake and energy expenditure, current studies suggest two other important influences on adult body weight: birth weight and postnatal rate of growth. A common procedure in laboratory ...

journal_title：Basic & clinical pharmacology & toxicology

authors： Coe BL,Kirkpatrick JR,Taylor JA,vom Saal FS

更新日期：2008-02-01 00:00:00

abstract：:It has been shown that newly initiated opioid therapy increases the risk of fall-related injuries. Yet, it remains to be determined whether drug-drug interactions can affect this negative effect, for instance with drugs inhibiting cytochrome P4502D6 (CYP2D6) that metabolizes codeine and also has a partial effect on tr...

journal_title：Basic & clinical pharmacology & toxicology

authors： Möller J,Laflamme L,Söderberg Löfdal K

更新日期：2015-02-01 00:00:00