Abstract：
:The aim of the present study was to examine the effects of formaldehyde solution on rat left ventricular function and compare it with those in hypertrophic hearts treated with isoproterenol by pressure-volume measurements with the catheter method. After 20-30 min. of intravenous infusion of 3.7% formaldehyde solution (FA) at 10 μl (3.7 mg)/kg/min, normal and hypertrophic hearts showed significant decreases in left ventricle end-systolic pressure (ESP), heart rate and cardiac output per minute, indicating an acute pumping failure. Hypertrophic hearts showed significantly smaller ESP, stroke volumes and cardiac output than those in normal hearts. Systolic pressure-volume area at midrange left ventricular volume (PVA(mLVV) : a mechanical work capability index) was significantly smaller than that in normal hearts and per cent of mean PVA(mLVV) versus pre-infusion mean value in hypertrophic hearts was significantly decreased compared to normal hearts 30 min. after FA infusion. The marked decrease in pH, base excess and no changes in PaO₂ and PaCO₂ suggest metabolic acidosis. The correction of metabolic acidosis with 9% NaHCO₃ did not influence on the acute pumping failure, indicating that metabolic acidosis did not cause it. Ultrastructural observations revealed marked dilation of the sarcoplasmic reticulum with intact sarcolemmal membranes and no disintegration of muscle myofibrils. Ryanodine receptors and calcium (Ca²⁺) pumps (SERCA2A) located in the sarcoplasmic reticulum have major roles in the cytosolic Ca²⁺ handling. Taken together, acute pumping failure by FA may derive from the impairment of Ca²⁺ handling in the cardiac excitation-contraction coupling.
journal_name
Basic Clin Pharmacol Toxicoljournal_title
Basic & clinical pharmacology & toxicologyauthors
Takeshita D,Nakajima-Takenaka C,Shimizu J,Hattori H,Nakashima T,Kikuta A,Matsuyoshi H,Takaki Mdoi
10.1111/j.1742-7843.2009.00442.xsubject
Has Abstractpub_date
2009-10-01 00:00:00pages
271-80issue
4eissn
1742-7835issn
1742-7843pii
PTO442journal_volume
105pub_type
杂志文章abstract：:The increasing size of spontaneous report data sets and the increasing capability for screening such data due to increases in computational power has led to a recent increase in interest and use of data mining on such data. While data mining plays an important role in the analysis of spontaneous reports, there is gene...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2006.pto_232.x
更新日期：2006-03-01 00:00:00
abstract：:Since the introduction of antivenom administration over a century ago to treat venomous snake bite, it has been the most effective therapy for saving life and limb. However, this treatment is not always effective and not without potential life-threatening side effects. We tested a new paradigm to abrogate the plasmati...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12654
更新日期：2017-02-01 00:00:00
abstract：:Aripiprazole is an antipsychotic that acts as a partial agonist at dopamine receptors. As the effects of most drugs of abuse converge to enhance dopamine-mediated neurotransmission, the present study was designed to test the hypothesis that aripiprazole would inhibit the acute effects of ethanol, a widely abused subst...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12036
更新日期：2013-05-01 00:00:00
abstract：:Histamine-2 receptor antagonists are a class of drugs used to treat the acid-related gastrointestinal diseases such as ulcer and gastro-oesophageal reflux disease. Although such drugs, especially ranitidine and famotidine, are still widely used, their effects on semen quality, and hence on male infertility, is still u...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12446
更新日期：2016-01-01 00:00:00
abstract：:Oxycodone is O-demethylated by CYP2D6 to oxymorphone which is a potent micro-receptor agonist. The CYP2D6 oxidation polymorphism divides the Caucasian population in two phenotypes: approximately 8% with no enzyme activity, poor metabolizers (PM) and the remainder with preserved CYP2D6 activity, extensive metabolizers ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,随机对照试验
doi：10.1111/j.1742-7843.2009.00378.x
更新日期：2009-04-01 00:00:00
abstract：:Natural dietary antioxidants are extensively studied for their ability to protect cells from miscellaneous damages. Origanum majorana L., Lamiaceae, is a potent antioxidant. The effect of administration of O. majorana (volatile oil, alcoholic and aqueous extracts) on oral administration of lead acetate in the diet of ...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2005.pto_136.x
更新日期：2005-10-01 00:00:00
abstract：:Hypericum androsaemum L. (Gutiferae) is a medicinal plant growing in Western Europe that has been used in traditional medicine in the prevention or treatment of liver diseases. Oxidative stress and nitrosative stress are common pathogenetic mechanisms contributing to initiation and progression of hepatic damage in sev...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00458.x
更新日期：2009-10-01 00:00:00
abstract：:Annona vepretorum Mart. (Annonaceae), popularly known as 'bruteira', has nutritional and medicinal uses. This study investigated the chemical composition and antitumour potential of the essential oil of A. vepretorum leaf alone and complexed with β-cyclodextrin in a microencapsulation. The essential oil was obtained b...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12488
更新日期：2016-03-01 00:00:00
abstract：:Seijo-bofu-to, a traditional medicine used to treat acne in Asian countries, contains twelve herbal components, including Angelica dahurica root, a source of furanocoumarin derivatives. In this study, we investigated potential herb-drug interactions of seijo-bofu-to in healthy male volunteers. Thirty-two young, health...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12224
更新日期：2014-10-01 00:00:00
abstract：:Much progress has happened in understanding developmental vulnerability to preventable environmental hazards. Along with the improved insight, the perspective has widened, and developmental toxicity now involves latent effects that can result in delayed adverse effects in adults or at old age and additional effects th...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.13162
更新日期：2019-08-01 00:00:00
abstract：:The last eight survivors of 80 workers accidentally exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD) during production of herbicides based on trichlorophenoxyacetic acid in 1965-1967 in a chemical factory were followed. All were men, mean age 72.4 ± 1.3 years. Their current median TCDD blood level was 112 (46-390...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12899
更新日期：2018-02-01 00:00:00
abstract：:Tamoxifen has been suggested to produce beneficial cardiovascular effects, although the mechanisms for these effects are not fully known. Moreover, although tamoxifen metabolites may exhibit 30-100 times higher potency than the parent drug, no previous study has compared the effects produced by tamoxifen and its metab...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00377.x
更新日期：2009-05-01 00:00:00
abstract：:Extracts of six commonly used commercially available herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut were investigated for their in vitro inhibitory potential of CYP3A4 mediated metabolism and P-glycoprotein efflux transport activity. C-DNA baculovir...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2008.00227.x
更新日期：2008-05-01 00:00:00
abstract：:Levels of cyclooxygenase-2 (COX-2) mRNA, but not those of COX-1, were reported to be raised significantly after peripheral inflammation in the rat spinal cord. The aim of the present study was to ascertain whether this pattern of COX-2 and COX-1 expression applies also to other pain conditions induced by surgical proc...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2006.pto_457.x
更新日期：2006-08-01 00:00:00
abstract：:In the present study, we investigated the hepatoprotective effects of salvianolic acid A, a novel antioxidant, against oxidative stress and acute liver injury induced by carbon tetrachloride (CCl(4)) in rats, and the mechanisms underlying its protective effects. Administration of CCl(4) to rats caused severe hepatic d...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7835.2007.00020.x
更新日期：2007-02-01 00:00:00
abstract：:Neuropilin tolloid-like protein 2 (Neto2) is an auxiliary subunit of kainate receptors (KARs). It specifically regulates KARs, for example slows desensitization and deactivation, increases the rate of recovery from desensitization, promotes modal gating and increases agonist sensitivity. Although the mechanism of Neto...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.12575
更新日期：2016-08-01 00:00:00
abstract：:Evidence of poor prescribing is widespread including overuse of medicines, underuse of effective medicines, avoidable adverse drug reactions and medication errors. Junior doctors who have recently graduated are responsible for much of the prescribing that takes place in hospitals and are implicated in many of the adve...
journal_title：Basic & clinical pharmacology & toxicology
pub_type：
doi：10.1111/j.1742-7843.2007.00141.x
更新日期：2007-12-01 00:00:00
abstract：:Gambogic acid, the main active compound of gamboge resin of Garcinia hanburryi, has recently exhibited marked antitumour potency on solid tumours of various derivations. We demonstrate here that gambogic acid also present powerful antileukaemic potency through both growth arrest and apoptosis induction in Jurkat cells...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2008.00292.x
更新日期：2008-12-01 00:00:00
abstract：:In order to perform relevant in vivo pharmacological investigations in drug discovery within dermatology it is fundamental to master or have access to relevant skin disease models that makes it possible to identify and validate targets and to screen and discover drugs in vivo. There is a strong need for highly predict...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2006.pto_298.x
更新日期：2006-08-01 00:00:00
abstract：:Nicotine-methadone interactions have been studied in human beings and in various experimental settings regarding addiction, reward and pain. Most methadone maintenance treatment patients are smokers, and methadone administration has been shown to increase cigarette smoking. Previous in vitro studies have shown that me...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12317
更新日期：2015-04-01 00:00:00
abstract：:Coated activated charcoal haemoperfusion (CAC-HP) is a well-known treatment modality. Case reports have revealed conflicting results about the efficacy of CAC-HP in the treatment of amitriptyline (AT) poisoning, and no randomized clinical trials have been identified in the literature. This study aimed at quantifying t...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12704
更新日期：2017-05-01 00:00:00
abstract：:Toxic epidermal necrolysis (TEN) is a life-threatening mucocutaneous disease with high mortality. Dithiocarbamates (DTC) are organosulphur compounds widely used in agriculture, industry and households. We report a case of TEN after exposure to mancozeb in fungicide. A 48-year-old 75 kg b.w. man was admitted with fever...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12430
更新日期：2016-01-01 00:00:00
abstract：:The six commonly used trade herbal products, St. John's wort, common valerian, common sage, Ginkgo biloba, Echinacea purpurea and horse chestnut, and ethanol, were investigated for their in vitro inhibitory potential of cytochrome P450 2D6 (CYP2D6)-mediated metabolism. Herbal components were extracted from commerciall...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2007.00121.x
更新日期：2007-11-01 00:00:00
abstract：:The endothelium plays crucial roles in modulating vascular tone by synthesizing and releasing endothelium-derived relaxing factors (EDRFs), including vasodilator prostaglandins, nitric oxide (NO) and endothelium-dependent hyperpolarization (EDH) factors. Thus, endothelial dysfunction is the hallmark of atherosclerotic...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/bcpt.13377
更新日期：2020-08-01 00:00:00
abstract：:Traditional non-steroidal anti-inflammatory drugs (NSAID) and selective cyclooxygenase-2 (COX-2) inhibitors are widely used in the treatment of pain, including bone fracture pain and orthopaedic post-operative pain. The gastrointestinal and cardiovascular adverse effects of NSAIDs are acknowledged, but their effects o...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章,评审
doi：10.1111/j.1742-7843.2007.00149.x
更新日期：2008-01-01 00:00:00
abstract：:The introduction of new COX-2 inhibitors with high efficacy and enhanced safety profile would be a great achievement in the development of anti-inflammatory drugs. This study was designed to screen and assess the anti-inflammatory and analgesic activities as well as some of the expected side effects of some pyrazole d...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2010.00648.x
更新日期：2011-04-01 00:00:00
abstract：:Clozapine and caffeine are metabolised mainly by the cytochrome P4501A2 (CYP1A2) enzyme. Studies suggest that caffeine in coffee inhibits clozapine metabolism and increases serum clozapine concentrations. Our objective was to study whether coffee in the amounts usually consumed has an effect on steady-state serum cloz...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 临床试验,杂志文章,随机对照试验
doi：
更新日期：2004-01-01 00:00:00
abstract：:The effects of different types of pesticides on the in vivo striatal dopamine release were investigated by using in vivo brain microdialysis technique. MPTP, paraquat, maneb, dicofol, DDT, lindane and flutriafol (1 mM) were administered directly into the striatum, and levels of dopamine and its metabolites dihydroxyph...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/j.1742-7843.2009.00468.x
更新日期：2009-12-01 00:00:00
abstract：:Vitamin D metabolism was studied in primary human dermal fibroblasts with focus on drug-mediated gene regulation related to adverse side effects of antiretroviral drugs used in HIV therapy. The fibroblasts expressed mRNA for cytochrome P450 (CYP) enzymes catalysing bioactivating (CYP2R1, CYP27A1 and CYP27B1) and catab...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12641
更新日期：2017-01-01 00:00:00
abstract：:Sudden death due to acute intoxication occurs frequently in patients with opioid addiction (OA). To examine whether certain genotypes were associated with this, we examined the frequencies of 29 SNPs located in candidate genes related to opioid pharmacology: ABCB1, OPRM1, UGT2B7, CYP3A5, CYP2B6, CYP2C19, CYP2D6, COMT,...
journal_title：Basic & clinical pharmacology & toxicology
pub_type： 杂志文章
doi：10.1111/bcpt.12602
更新日期：2016-10-01 00:00:00
