Abstract:
:We report a new preparative method for providing contrast through reduction in electron density that is uniquely suited for propagation-based differential x-ray phase contrast imaging. The method, which results in an air or fluid filled vasculature, makes possible visualization of the smallest microvessels, roughly down to 15 microm, in an excised murine liver, while preserving the tissue for subsequent histological workup. We show the utility of spatial frequency filtering for increasing the visibility of minute features characteristic of phase contrast imaging, and the capability of tomographic reconstruction to reveal microvessel structure and three-dimensional visualization of the sample. The effect of water evaporation from livers during x-ray imaging on the visibility of blood vessels is delineated. The deformed vascular tree in a cancerous murine liver is imaged.
journal_name
Phys Med Bioljournal_title
Physics in medicine and biologyauthors
Laperle CM,Hamilton TJ,Wintermeyer P,Walker EJ,Shi D,Anastasio MA,Derdak Z,Wands JR,Diebold G,Rose-Petruck Cdoi
10.1088/0031-9155/53/23/017subject
Has Abstractpub_date
2008-12-07 00:00:00pages
6911-23issue
23eissn
0031-9155issn
1361-6560pii
S0031-9155(08)83775-Xjournal_volume
53pub_type
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