Relationship of body fat distribution pattern to atherogenic risk factors in NIDDM. Preliminary results.

Abstract:

:Because recent knowledge indicates that the distribution of fat deposits in men may be a better predictor of cardiovascular disease than the degree of obesity alone, some risk factors for atherosclerosis were evaluated in 51 middle-aged men with non-insulin-dependent diabetes mellitus. Abdominal adiposity (waist/hip ratio, WHR) was related to parameters of metabolic control, lipid parameters, and known vascular complications in three different groups. In groups with abdominal obesity, mean annual hemoglobin A1 was significantly (P less than .01) higher than in patients without an abdominal fat distribution. Atherogenic index was significantly increased in the group with the highest WHR and high-density lipoprotein cholesterol (HDL-chol) levels were significantly decreased in both groups with upper-body fat distribution. The frequency of peripheral vascular disease, coronary ischemic heart disease, and hypertension was most prominent in diabetic subjects with an abdominal fat mass distribution. A highly significant (P less than .001) correlation was present between WHR and HDL-chol and WHR and the total-cholesterol/HDL-chol ratio; this significant correlation remains after correction for body mass index. A similar correlation could be found between WHR and systolic and diastolic blood pressures. These results demonstrate an association of excess abdominal fat, even without manifest obesity, with worse diabetes metabolic control, cardiovascular complications, and blood lipid levels actually considered to play an important role in atherogenesis.

journal_name

Diabetes Care

journal_title

Diabetes care

authors

Van Gaal L,Rillaerts E,Creten W,De Leeuw I

doi

10.2337/diacare.11.2.103

subject

Has Abstract

pub_date

1988-02-01 00:00:00

pages

103-6

issue

2

eissn

0149-5992

issn

1935-5548

journal_volume

11

pub_type

杂志文章
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    journal_title:Diabetes care

    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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    doi:10.2337/diacare.8.2.172

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  • Quantitative importance of dietary constituents other than glucose as insulin secretagogues in type II diabetes.

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    pub_type: 杂志文章

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    更新日期:1988-01-01 00:00:00

  • Bariatric/Metabolic Surgery to Treat Type 2 Diabetes in Patients With a BMI

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    pub_type: 杂志文章,meta分析

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    pub_type: 杂志文章

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    更新日期:1983-01-01 00:00:00

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  • Pancreatic Effects of Liraglutide or Sitagliptin in Overweight Patients With Type 2 Diabetes: A 12-Week Randomized, Placebo-Controlled Trial.

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  • Adult respiratory distress syndrome complicating severely uncontrolled diabetes mellitus: report of nine cases and a review of the literature.

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  • Gestational diabetes, pregnancy hypertension, and late vascular disease.

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  • Efficacy of metabolic and psychological screening for mood disorders among children with type 1 diabetes.

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  • Personal-model beliefs and social-environmental barriers related to diabetes self-management.

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  • Sugar content of selected pharmaceuticals.

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    pub_type: 杂志文章

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  • Glycosylated hemoglobin in relation to rapid fluctuations in blood glucose in children with insulin-dependent diabetes: a comparison of methods with and without prior dialysis.

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    journal_title:Diabetes care

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  • Variability of urinary albumin excretion in patients with microalbuminuria.

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    pub_type: 临床试验,杂志文章,多中心研究,随机对照试验

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  • Multifaceted determinants for achieving glycemic control: the International Diabetes Management Practice Study (IDMPS).

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    pub_type: 杂志文章

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  • Pulse pressure and prediction of incident foot ulcers in type 2 diabetes.

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    pub_type: 杂志文章

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  • Oral disposition index predicts the development of future diabetes above and beyond fasting and 2-h glucose levels.

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    journal_title:Diabetes care

    pub_type: 杂志文章

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    更新日期:2009-02-01 00:00:00

  • Evaluation of two methods of self blood glucose monitoring by trained insulin-dependent diabetic adolescents outside the hospital.

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    journal_title:Diabetes care

    pub_type: 杂志文章

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    authors: Schiffrin A,Desrosiers M,Belmonte M

    更新日期:1983-03-01 00:00:00

  • High systolic blood pressure increases prevalence and severity of retinopathy in NIDDM patients.

    abstract:OBJECTIVE:To determine whether the severity of retinopathy is higher in a group of NIDDM patients with sBP greater than or equal to 140 mmHg compared with NIDDM patients with sBP less than 140 mmHg. RESEARCH DESIGN AND METHODS:Ophthalmoscopy and FAG were conducted among a group of NIDDM patients with either a sBP abov...

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    pub_type: 杂志文章

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    更新日期:1992-08-01 00:00:00

  • Does patient behavior or access factors have the largest influence on screening in type 1 diabetes?

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc06-1279

    authors: Dorsey R,Songer T,Zgibor J,Kelsey S,Ibrahim S,Orchard T

    更新日期:2007-04-01 00:00:00

  • 25-hydroxyvitamin D concentrations and in vivo insulin sensitivity and β-cell function relative to insulin sensitivity in black and white youth.

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    journal_title:Diabetes care

    pub_type: 杂志文章

    doi:10.2337/dc11-1825

    authors: Rajakumar K,de las Heras J,Lee S,Holick MF,Arslanian SA

    更新日期:2012-03-01 00:00:00

  • Effect of automated bio-behavioral feedback on the control of type 1 diabetes.

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    journal_title:Diabetes care

    pub_type: 杂志文章,随机对照试验

    doi:10.2337/dc10-1366

    authors: Kovatchev BP,Mendosa P,Anderson S,Hawley JS,Ritterband LM,Gonder-Frederick L

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  • Markers of platelet activation are increased in adolescents with type 2 diabetes.

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    pub_type: 杂志文章

    doi:10.2337/dc13-2718

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  • Effect of rimonabant on glycemic control in insulin-treated type 2 diabetes: the ARPEGGIO trial.

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    pub_type: 杂志文章,多中心研究,随机对照试验

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