Abstract:
:This review focuses on pharmacophore approaches in researching protein interfaces that bind protein ligands. Pharmacophore descriptions of binding interfaces that employ molecular dynamics simulation can account for effects of solvation and conformational flexibility. In addition, these calculations provide an approximation to entropic considerations and as such, a better approximation of the free energy of binding. Residue-based pharmacophore approaches can facilitate a variety of drug discovery tasks such as the identification of receptor-ligand partners, identifying their binding poses, designing protein interfaces for selectivity, or defining a reduced mutational combinatorial exploration for subsequent experimental engineering techniques by orders of magnitudes.
journal_name
Curr Opin Struct Bioljournal_title
Current opinion in structural biologyauthors
Shrestha R,Fajardo JE,Fiser Adoi
10.1016/j.sbi.2020.12.016subject
Has Abstractpub_date
2021-01-21 00:00:00pages
205-211eissn
0959-440Xissn
1879-033Xpii
S0959-440X(21)00009-9journal_volume
67pub_type
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